不同氧合器对体外循环心脏手术患儿中性粒细胞凋亡的影响

Objective To evaluate the effect of two kind oxygenators on polymorphonuclear neutrophil (PMN) apoptosis, and to give a method of inhibting the systemic inflammatory response syndrome(SIRS) to cardiopulmonary bypass(CPB). Methods Sixty VSD patients undergoing open heart surgery with CPB were randomly divided into two groups(n = 30): group B(bubble oxygenator), group M(membrane oxygenator). Blood samples were drawn from the central venous line before starting CPB, at the end of CPB, 4, 8 and 24 h after CPB. The PMN counts were performed by blood cell counter. PMN apoptosis and the expression of CD11b were evaluated by flow eytometry. The plasma concentration of elastase was determined by enzyme linked immunosorbent assays. Results The rates of PMN apoptosis were significantly reduced (P<0.05) and the PMN counts, the expression of CD11b and the plasma con-centration of elastase were remarkably increased after CPB(P<0.05), but at the end of CPB, 4 h and 8 h after CPB the rate of PMN apoptosis was higher in group M than that in group B. PMN counts, the expression of CDI lb and the plasma concentration of elastase were higher in group B than in group M (P<0.05). The PMN counts were higher in group B than in group M 24 h after CPB (P< 0.05). Conclusion XiJian-Ⅱ membrane oxygenator can increase PMN apoptosis and depress systemic inflammatory response better than XIJing-90 bubble oxygenator.     

不同氧合器对体外循环心脏手术患儿中性粒细胞凋亡的影响

Objective To evaluate the effect of two kind oxygenators on polymorphonuclear neutrophil (PMN) apoptosis, and to give a method of inhibting the systemic inflammatory response syndrome(SIRS) to cardiopulmonary bypass(CPB). Methods Sixty VSD patients undergoing open heart surgery with CPB were randomly divided into two groups(n = 30): group B(bubble oxygenator), group M(membrane oxygenator). Blood samples were drawn from the central venous line before starting CPB, at the end of CPB, 4, 8 and 24 h after CPB. The PMN counts were performed by blood cell counter. PMN apoptosis and the expression of CD11b were evaluated by flow eytometry. The plasma concentration of elastase was determined by enzyme linked immunosorbent assays. Results The rates of PMN apoptosis were significantly reduced (P<0.05) and the PMN counts, the expression of CD11b and the plasma con-centration of elastase were remarkably increased after CPB(P<0.05), but at the end of CPB, 4 h and 8 h after CPB the rate of PMN apoptosis was higher in group M than that in group B. PMN counts, the expression of CDI lb and the plasma concentration of elastase were higher in group B than in group M (P<0.05). The PMN counts were higher in group B than in group M 24 h after CPB (P< 0.05). Conclusion XiJian-Ⅱ membrane oxygenator can increase PMN apoptosis and depress systemic inflammatory response better than XIJing-90 bubble oxygenator.     

机械通气病人的呼吸道管理

机械通气越来越广泛地用于治疗各种原因所致的呼吸障碍，它的临床应用抢救了许多危重患者的生命，但若护理不当会导致严重的肺部并发症，增加死亡率。现将我院103例机械通气病人的呼吸道管理体会介绍如下。     

经皮肾镜肾盂结石钬激光碎石术的手术配合

目的：总结泌尿外科实施经皮肾镜肾盂结石钬激光碎石术的手术护理经验。方法：对2006年2月～2007年2月共58例经皮肾镜肾盂结石钬激光碎石手术的患者进行围手术期观察护理。结果：手术时间100～160min,平均125min。平均出血量300ml。术中术野清晰,无明显出血,1例中转切开取石。无患者出现排尿困难、尿潴留、尿失禁等并发症。结论：钬激光是一种新型的手术激光,对于仪器和器械的要求非常严格,需专人负责保管和使用。经皮肾镜肾盂结石钬激光碎石术创伤小、缩短了患者住院天数。     

呼吸过滤器在人工通气中的作用及对气道的影响

人工通气时由于失去了上呼吸道的生物滤过和保温、保湿功能,可能引发呼吸道感染、低温等并发症.本文结合现状描述了呼吸过滤器生物滤过、保温、保湿作用机制及其对气道压和呼出气末CO2分压的影响机制,并指出呼吸过滤器存在的应用风险及禁忌情况,为临床选择应用合适的呼吸过滤器提供充分的理论依据.     

开胸术患者恢复期躁动的原因及护理对策

术后躁动是气管内全麻常见的并发症。严重时可危害患者的生命安全。2002年8月-2007年6月，我们共收治恢复期躁动开胸患者104例。现分析其原因，并总结护理对策。     

舒芬太尼对全麻开胸手术患者苏醒期躁动的预防效果观察

选择全麻下择期行开胸手术的80例患者,随机分为A、B两组,各40例.A组在术毕前10min用静脉镇痛泵输注舒芬太尼0.06μg/(kg·h);B组为对照组,常规处理.记录麻醉苏醒期患者躁动发生率及苏醒期操作配合程度.认为全麻开胸手术患者术毕前应用舒芬太尼可有效预防全麻苏醒期躁动的发生率,并能明显降低躁动程度.     

全程心理疏导联合术后镇痛对全身麻醉开胸手术患者苏醒期躁动的影响

目的 评价全程心理疏导联合术后镇痛预防全身麻醉开胸手术患者苏醒期躁动的临床效果.方法 选择全身麻醉下行择期开胸手术患者160例,随机分为4组:常规访视组(A组)、全程心理疏导组(B组)、术后镇痛组(C组)及全程心理疏导联合术后镇痛组(D组),每组40例.记录麻醉前(T0)、手术结束时(T1)、拔出气管导管即刻(T2)、拔出气管导管后5 min(T3)、拔出气管导管后10 min(T4)的平均动脉压(MAP)、心率(HR),观察并记录患者麻醉苏醒期操作配合程度及苏醒期躁动发生率.结果 4组患者术后苏醒时间和拔管时间组间差异无统计学意义(P＞0.05).A、B、C 3组患者T2时MAP水平和HR水平与T0时比较,差异均有统计学意义(P＜0.05).A组苏醒期躁动发生率与B组、C组及D组比较,D组与B组、C组比较,差异均有统计学意义(P＜0.05).结论 开胸手术患者实施全程心理疏导联合术后镇痛的综合性措施,可降低麻醉苏醒期蹂动的发生率,提高患者的安全度与舒适度.     

不同氧合器对体外循环心脏手术患儿中性粒细胞凋亡的影响

Objective To evaluate the effect of two kind oxygenators on polymorphonuclear neutrophil (PMN) apoptosis, and to give a method of inhibting the systemic inflammatory response syndrome(SIRS) to cardiopulmonary bypass(CPB). Methods Sixty VSD patients undergoing open heart surgery with CPB were randomly divided into two groups(n = 30): group B(bubble oxygenator), group M(membrane oxygenator). Blood samples were drawn from the central venous line before starting CPB, at the end of CPB, 4, 8 and 24 h after CPB. The PMN counts were performed by blood cell counter. PMN apoptosis and the expression of CD11b were evaluated by flow eytometry. The plasma concentration of elastase was determined by enzyme linked immunosorbent assays. Results The rates of PMN apoptosis were significantly reduced (P<0.05) and the PMN counts, the expression of CD11b and the plasma con-centration of elastase were remarkably increased after CPB(P<0.05), but at the end of CPB, 4 h and 8 h after CPB the rate of PMN apoptosis was higher in group M than that in group B. PMN counts, the expression of CDI lb and the plasma concentration of elastase were higher in group B than in group M (P<0.05). The PMN counts were higher in group B than in group M 24 h after CPB (P< 0.05). Conclusion XiJian-Ⅱ membrane oxygenator can increase PMN apoptosis and depress systemic inflammatory response better than XIJing-90 bubble oxygenator.     

不同氧合器对体外循环心脏手术患儿中性粒细胞凋亡的影响

Objective To evaluate the effect of two kind oxygenators on polymorphonuclear neutrophil (PMN) apoptosis, and to give a method of inhibting the systemic inflammatory response syndrome(SIRS) to cardiopulmonary bypass(CPB). Methods Sixty VSD patients undergoing open heart surgery with CPB were randomly divided into two groups(n = 30): group B(bubble oxygenator), group M(membrane oxygenator). Blood samples were drawn from the central venous line before starting CPB, at the end of CPB, 4, 8 and 24 h after CPB. The PMN counts were performed by blood cell counter. PMN apoptosis and the expression of CD11b were evaluated by flow eytometry. The plasma concentration of elastase was determined by enzyme linked immunosorbent assays. Results The rates of PMN apoptosis were significantly reduced (P<0.05) and the PMN counts, the expression of CD11b and the plasma con-centration of elastase were remarkably increased after CPB(P<0.05), but at the end of CPB, 4 h and 8 h after CPB the rate of PMN apoptosis was higher in group M than that in group B. PMN counts, the expression of CDI lb and the plasma concentration of elastase were higher in group B than in group M (P<0.05). The PMN counts were higher in group B than in group M 24 h after CPB (P< 0.05). Conclusion XiJian-Ⅱ membrane oxygenator can increase PMN apoptosis and depress systemic inflammatory response better than XIJing-90 bubble oxygenator.