心室肌脂肪:一个意想不到的远期生存生物标志物?

正目的非增强CT常常观察到心肌脂肪,但对其认识不足,本文旨在探究心肌内脂肪与全因死亡率的关系,无论是否有心肌梗死病史。方法本回顾性队列研究收集了不     

美国≥65岁女性的数字二维乳腺摄影与断层成像对比

正摘要虽然乳腺癌的发病率和死亡率随着年龄的增长而增加,但有关老年妇女筛查乳腺X线检查的益处和风险,以及老年妇女二维数字乳腺X线摄影(DM)和数字乳腺断层成     

Significant impact of cryopreserved amniotic membrane on acute ocular Stevens-Johnson syndrome and toxic epidermal necrolysis

The ocular surface is covered by an epithelium encompassing an area including the cornea,the limbus and the conjunctiva bordered by the upper and lower lids.The healthy state of the ocular surface epithelium depends on a stable and protective preocular tear film when the eye is open.A stable preocular tear film is governed by sound ocular surface defense that involves effective neuroanatomic integration of compositional and hydrodynamic factors by two neural reflexes (1).     

经梨状肌和臀小肌间隙入路行全髋关节置换对老年髋部骨折的治疗效果及病人生存质量的影响

目的探究经梨状肌和臀小肌的间隙入路行全髋关节置换对老年髋部骨折的治疗效果及病人生存质量的影响。方法选取96例老年髋部骨折病人(108髋)为本研究对象，其中50例病人(55髋)行后外侧入路全髋关节置换术为A组，46例病人(53髋)行经梨状肌和臀小肌间隙入路全髋关节置换术为B组，记录对比2组病人围手术期情况(手术时间、切口最大长度、术中出血量、术后下地时间)、并发症情况、术前术后髋关节HHS评分、VAS疼痛评分和下肢功能变化情况、术后6个月病人影像学指标情况(外展角、前倾角、偏心距)和生存质量情况(以SF-36量表表示)。结果A组病人手术时间、切口长度短于B组，术后首次下地时间长于B组(P < 0.05~P < 0.01)；A组病人术后1、3、7 d的HISS评分低于B组，VAS评分高于B组(P < 0.05~P < 0.01)，2组病人术前、术后14、30、90、180 d的HISS和VAS评分差异无统计学意义(P>0.05)；B组病人术后30、90 d“起立-行走”计时测试显著优于A组，术后30 d单腿站立测试时间长于A组，术后90 d的6 min步行测试距离优于A组(P < 0.05)，其他时间点2组病人下肢功能情况差异无统计学意义(P>0.05)；A组前倾角小于B组，偏心距大于B组(P < 0.05)；B组病人SF-36评分量表肢体功能、社会功能、心理健康和总健康程度得分均优于A组(P < 0.05)。结论相比于传统后外侧入路行全髋关节置，经梨状肌与臀小肌间隙入路对老年髋部骨折病人的损伤更小、恢复更快，近期疗效指标显著优于传统术式，符合快速康复理念，但手术时长显著增加，病人术后前倾角偏大，偏心距偏小。     

Glial regenerative response in the imaginal discs of Drosophila melanogaster

<正>Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional plasticity.In response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior     

Tandem pore TWIK-related potassium channels and neuroprotection

TWIK-related potassium channels(TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notwithstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.     

多参数MR成像全肿瘤直方图分析三阴性乳腺癌与其他亚型的鉴别

正摘要目的利用多参数MR成像图谱和全肿瘤直方图分析三阴性(TN)乳腺癌与其他分子亚型鉴别的影像学生物标志。方法本回顾性研究包括134例浸润性导管癌病人。从     

慢性血栓栓塞性肺动脉高压病人在球囊血管成形术前后的肺灌注血容量CT、肺灌注SPECT、肺血管造影的临床及预测价值比较

正摘要目的使用双能量CT计算肺灌注血容量(PBV)诊断肺血栓栓塞已被广泛接受。本研究评价慢性血栓栓塞性肺高压(CTEPH)病人在球囊肺血管成形术(BPA)前、后的肺     

使用棱镜重新定位双侧中心暗点患者视网膜物像的预试验

目的 本研究使用激光扫描检眼镜(SLO)评价双侧中央暗点患者使用棱镜后的眼球运动反应.方法 本预试验共招募6例有双侧中央暗点的年龄相关性黄斑变性(AMD)患者以及6例正常视力的志愿者.首先用Nidek MP-1微视野仪确认患者的中央暗点和优选视网膜注视点(PRL),然后用Rodenstock SLO,在将视标投射在优选视网膜注视点时拍下实时视网膜像,接着在受检者眼前加入6～8 PD的棱镜,要求受检者保持注视视标,这时通过视网膜标记来测量视网膜像的移位量,以及随后发生的优选视网膜注视点的再次注视.过程中平均移位量和再次注视时间通过图像软件(ImageJ software)来计算.结果 实验组再次注视时的移位量在3个像素点或11.66个弧分之内(x轴:2.90±3.92,y轴:2.53±4.18).对照组再次注视时的移位会准确些(x轴:0.33±1.15,y轴:0.89±2.50),但与实验组差异无统计学意义(tx=1.32,Px＞0.05;ty=0.80,Py＞0.05).对照组再次注视时间(0.98±0.19)s较实验组(2.83±1.63)s要短,差距有统计学意义(t=5.03,P＜0.01).其中有1例实验组受检者没有发生再次注视,其结果被排除并单独分析.结论 研究发现,双眼中央暗点患者对棱镜物像转移后的再注视反应与正常人接近,但实验组再注视明显较对照组慢,并有1例受检者没有发生再注视.该数据说明双侧中央暗点患者无论眼前有没有棱镜,都会利用相同的视网膜位置视物,因此,通过棱镜物像再定位的意义不大.     

软组织肉瘤:与组织学分级和病人预后相关的MRI特征评估

正摘要软组织肉瘤的治疗依赖于组织学分级,这是最重要的预后因素和活检后常规评估。然而,由于肿瘤的异质性,组织学分级可能会被低估。目的确定与高级别软组织肉瘤