Effect of autocontrol micromotion intramedullary interlocking nail on fracture healing： an experimental study

Objective: To investigate the effect of autocontrol micromotion locking nail ( AMLN ) on experimental fracture healing and its mechanism. Methods: 16 goats undergoing both sides of transverse osteotomy of the femoral shafts were fixed intramedullary with AMLN and Gross-Kempf (GK) nail, respectively. The follow-up time was 7, 14, 28 and 56 days. Roentgenographic, biomechanical, histological, scanning electromicroscopic and biochemical analyses were done. Results: (1) The strength of anticompression, antiflexion and antitorsion in the fractural end in the AMLN-fixed group was higher than that of GK nail-fixed group; whereas, the rate of stress shelter in the fractured end decreased significantly (P<0.01). (2) The content of the total collagen, insoluble collagen, calcium and phosphate in the AMLN-fixed group was higher than that in the GK nail-fixed group (P<0.05). (3) Histological observation and quantitative analysis of calluses revealed that AMLN could promote the growth of bridge calluses and periosteum calluses. Hence the facture healing and remolding process achieved early, which was much better than traditional GK nail fixation. (P<0.05). (4) 7-14 days postoperation, the calluses of AMLN-fixed group was flourish and camellarly arranged and the collagen fibril formed constantly in the absorption lacuna of bone trabecula. 28-56 days postoperation, the collagen fibril was flourish around the absorption lacuna and was parallel to the bone's longitudinal axis. Active bony absorption and formation were seen, so was remolding and rebuilding. Haversian system was intact and the bony structural net was very tenacious because of the deposition of calcium salt. None of the above findings was observed in the GK nailfixed group. Conclusions: The design of AMLN accords well with the plastic fixation theory. As the geometry ametabolic system constituted by the intramedullary fixation instruments and the proximal and distal end of the fracture is very firm and stable, the disturbance to the physical stress distributed in the fractural end is light. The generation and conduct of the intermittent physical stress between the fractural parts could reach the balance between stress conduct and stress protection. The feature that the healing and remolding take place at the same time speeds up the fractural healing process.     

带血管蒂岛状筋膜瓣移植治疗晚期类风湿性髋关节炎

目的：阐明带血管蒂岛状筋膜瓣移植治疗晚期类风湿性髋关节炎的疗效。材料和方法：对４２例４８髋晚期类风湿性髋关节炎病人采用以旋股外侧血管降支为蒂的股前外侧筋膜瓣移植行患髋成形术。结果：术后随访４～１０．５年，平均４．５年，髋关节活动范围术前平均１６．５°，术后２２８．６°，按照Ｃｈａｒｎｌｅｙ和吴之康人工髋关节置换术后的疗效评定标准，优良２９髋、很好１３髋、好６髋，尚可、差、很差无。结论：患者年龄在１５～４０岁之间为合适的治疗年龄。与人工髋关节置换术相比，本方法对髋关节正常结构破坏小；一旦手术失败仍可选用其它治疗方法弥补；且并发症少、费用低、远期效果好。     

颈椎间盘突出症的髓核突出类型及其临床意义

目的对颈椎间盘突出症进行分型,并探讨其临床意义。方法手术治疗颈椎间盘突出症110例,根据MRI特点分为Ⅰ型,Ⅱ型和Ⅲ型,并就分型和临床的关系,选择手术方式。结果两节段以下的各型突出,含有Ⅱ型或Ⅲ型突出的多节段颈椎间盘突出,伴动力性颈椎不稳的各型突出,均应首选前路手术;三节段以上的Ⅰ型突出,发育性颈椎管狭窄合并Ⅱ型或Ⅲ型突出,应选择后路手术。结论颈椎间盘突出症的分型对手术入路选择有指导意义。     

改进带蒂腱膜修补术治疗再发性跟腱断裂

目的：了解改进带蒂腱膜修补术治疗再发跟腱断裂的长期疗效。方法：对平均病程为3个月的12例再发跟腱断裂患者进行了平均6．15年的术后随访，所有患者均采用改进带蒂腱膜修补术的手术方法，并用Amer-Lindholm疗效评定标准进行评定。结果：术辱疗效优8例(65．8％)，良3例(25％)，差1例(9．2％)，优良率达90．8％。结论：再发跟腱断裂手术较为困难，本术式涪疗再发跟腱断裂取得了良好的手术疗效。     

人骨肉瘤中p53和Rb蛋白免疫组化研究的初步报告

为了研究ｐ５３、Ｒｂ基因和国人骨肉瘤的关系，作者应用ＬＳＡＢ免疫组织化学方法检测了３０例人骨肉瘤、１５例胎儿骨和１５例正常骨组织中ｐ５３蛋白和Ｒｂ蛋白的表达情况。结果发现，与正常骨和胎儿骨相比，骨肉瘤中有高水平的ｐ５３蛋白和低水平Ｒｂ蛋白表达，差异均有显著意义（Ｐ＜０．０５）。此外还发现，骨肉瘤中ｐ５３蛋白和Ｒｂ蛋白的表达结果呈负相关（ｒ＝－０．４１４，Ｐ＜０．０５）。本研究结果提示，ｐ５３基因突变和Ｒｂ基因异常在骨肉瘤的发生中可能起着一定的作用。     

人骨肉瘤中Bcl-2和PCNA的表达

目的研究骨肉瘤中Bcl-2和PCNA表达的生物学意义.方法用免疫组织化学S-P法,研究 30例骨肉瘤和 15例正常骨中Bcl-2和PCNA表达情况.结果骨肉瘤组与正常骨组,骨肉瘤Ⅱ、Ⅲ级组与Ⅰ级组,骨肉瘤生存组与死亡组相比, PCNA指数差异有显著性 (P<0.05).骨肉瘤组与正常骨组相比,Bcl-2差异有显著性(P<0.05).骨肉瘤Ⅱ、Ⅲ级组与Ⅰ级组,骨肉瘤生存组与死亡组相比,Bcl-2差异无显著性(P>0.05).骨肉瘤中Bcl-2和PCNA表达呈显著相关性(P<0.05).结论细胞凋亡抑制和过度增殖协同作用导致骨肉瘤的发生.PCNA指数可作为反映骨肉瘤分级和预后的指标.Bcl-2不能作为判断骨肉瘤分级和预后的指标.     

锁骨骨折诊疗策略

目的：探讨锁骨骨折诊疗方案，提高治疗水平。方法：150例锁骨骨折，新鲜骨折125例，陈旧性骨折25例，按照骨折的不同类型给予手法复位或内固定术。结果：均得到6个月～3年随访，无畸型愈合、不愈合及功能障碍。结论：按照不同的分型，分类治疗，可以提高疗效，减少并发症。     

98例糖尿病脑梗死血压与预后临床分析

本文回顾分析 98例糖尿病脑梗死患者的临床资料 ,探讨不同血压状况对脑梗死急性期预后的影响。1　资料与方法1 1　临床资料　糖尿病脑梗死 98例系我院 1997年 1月～ 1998年 12月住院患者 ,男 45例 ,女 5 3例 ;年龄 40～ 80岁 ,平均 6 5 6 0± 7 5 5岁。根据既往糖尿病、高血压病史及入院后前 3天血压测定 ,分为正常血压梗死组 (2 5例 ) ,原发性高血压糖尿病组 (简称高血压糖尿病组 44例 ) ,及糖尿病并发高血压组 (简称糖尿病高血压组 2 9例 ) ;三组年龄、性别无统计学差异。糖尿病按ＷＨＯ 1985年诊断标准确诊 ,全部为Ⅱ型糖尿病 ;脑梗死按…     

骨肉瘤的分子遗传学研究现状

骨肉瘤的分子遗传学研究现状赵炬才李文辉作者单位∶４５０００３郑州，河南省人民医院骨研所骨肉瘤是一种严重危害青少年健康的最常见的骨原性肿瘤，约占所有骨肿瘤的２０％。近几年的骨肉瘤的分子遗传学研究进展很快，研究的力度也逐渐加深，方法更为先进、精确，除了对...