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重视器官移植术后胃肠道肿瘤的发生与治疗 总被引:2,自引:0,他引:2
器官移植术作为治疗终末期脏器疾病及脏器功能衰竭的有效方法,已广泛应用于临床.至2006年,据不完全统计,我国开展的肾移植病例已超过60 000例,肝移植病例超过7 000例,同时大器官移植包括心脏、胰腺、小肠移植以及多脏器联合移植等也有了一定规模的开展. 相似文献
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在临床工作中,经常会遇到一些特殊类型的胃肿瘤,如胃肠间质瘤(GIST)、胃神经内分泌肿瘤(NETs)、原发性胃淋巴瘤(PGL)及特殊类型的胃癌.由于其所具有的特殊的发病机制、组织来源和病理类型,使得疾病本身可供选择的治疗手段相对较少,临床治疗效果有限;同时,其较低的发病率可能容易造成临床医师认识不足.本文通过对此类胃肿瘤进行阐述分析,以提高临床对该类疾病的认识和重视. 相似文献
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我国胃癌每年的发病人数和死亡人数均居世界首位, 而胃癌是一种异质性个体差异极大的疾病, 预后较差, 治疗效果不佳。近年来随着包括基因组学在内多组学技术的发展, 通过深入剖析胃癌的不同分子亚型及内在机制, 寻找到胃癌相关的分子靶点及分子特征, 基于此类分子特征研判、开发的靶向或免疫治疗药物, 部分已应用于胃癌的临床治疗。笔者梳理国内外该领域研究最新进展, 以胃癌分子分型为基础, 阐述胃癌精准治疗策略现状与展望, 以期为提高胃癌综合治疗疗效, 改善胃癌患者预后和生存提供理论依据和新思路。 相似文献
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Objective To investigate the influence of CO2 pneumoperitoneum on the adhesive and invasive ability of gastric cancer cells based on the expression of adhesive and invasive molecules. Methods With an artificial CO2 pneumoperitoneum model in vitro, human gastric cancer cells MKN-45, SGC-7901 and MKN-28 were exposed to 3 different CO2 gradients: 9 mm Hg, 15 mm Hg and control group (0 mm Hg). The expression of E-cadherin, ICAM-1, MMP-2 and VEGF-A were measured at 2 and 4 hours exposure by using RT-PCR, CytoMatrixTM kit and ECMatrixTM kit. The pretreated gastric cancer cells were injected into abdominal cavity of nude mice(2×106 cells per mouse). Five mice in each group were sacrificed 4 weeks later to record the number of tumor nodules in abdominal cavity. The remaining mice were kept for observation of survival time. Results The expression of E-cadherin (MKN-45: from 2.26 to 2.19, SGC-7901 :from 2.16 to 2.09、MKN-28 :from 2.06 to 1.99), ICAM-1 (MKN-45 : from 2.20 to 2.28、SGC-7901: from 2.10 to 2.18、MKN-28: from 2.00 to 2.08), MMP-2 (MKN-45:from 2.05 to 2.13、SGC-7901: from 1.95 to 2.03、MKN-28: from 1.85 to 1.93) and VEGF-A(MKN-45 : from 2.10 to 2.16、SGC-7901 :from 2.00 to 2.06、MKN-28: from 1.90 to 1.96) didn't change significantly with increasing pressure and time (P>0.05). The expression of adhesive and invasive molecules didn't change significantly between the experimental groups and the control group. There was no statistical significance of tumor metastasis in abdominal cavity of nude mice(MKN-45:from 22 to 23、SGC-7901 :from 20 to 22、MKN-28:from 21 to 22) and survival time(MKN-45 :from 23 to 21、SGC-7901 :from 22 to 21、MKN-28 :from 22 to 21) among all the groups. Conclusion Under low pressure and short time of CO2 exposure, the adhesive and invasive capacity of gastric cancer cells did not change significantly hence did not increase the possibility of neoplasm metastasis. 相似文献
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目的 探讨伊马替尼(IM)对中高度复发风险胃肠道间质瘤(GIST)患者的术后辅助治疗疗效及其优化措施.方法 回顾性分析2004年1月至2012年9月间接受R0手术切除的连续225例中高危原发GIST患者(中危62例,高危163例)的临床及随访资料,比较接受IM辅助治疗及未接受IM辅助治疗两组患者的术后复发情况.结果 在中危GIST患者中,服药组与未服药组相比,5年无复发生存率(RFS)分别为83.3%和88.6%,两组生存曲线差异无统计学意义(P=0.647);高危GIST患者中,服药组与未服药组术后1年的RFS分别为93.5%和81.2%,差异有统计学意义(P=0.037),而术后5年RFS分别为56.1%和50.2%,两组生存曲线比较差异无统计学意义(P=0.112);此外,在高危GIST患者中,核分裂象>10/HPF或有局部浸润的服药组和未服药组患者比较,服药组术后1年的复发率均显著低于未服药组,P值分别为0.022和0.036,而核分裂相≤10/HPF且无局部浸润的服药和未服药组患者术后1年的复发率差异无统计学意义(P=0.789).结论 GIST术后IM辅助治疗可有效延缓肿瘤复发,但不能预防IM停药后的肿瘤复发,对于核分裂象>10/HPF或伴有局部浸润的高危GIST患者,应尽量延长术后IM的辅助治疗时间. 相似文献
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Objective To investigate the influence of CO2 pneumoperitoneum on the adhesive and invasive ability of gastric cancer cells based on the expression of adhesive and invasive molecules. Methods With an artificial CO2 pneumoperitoneum model in vitro, human gastric cancer cells MKN-45, SGC-7901 and MKN-28 were exposed to 3 different CO2 gradients: 9 mm Hg, 15 mm Hg and control group (0 mm Hg). The expression of E-cadherin, ICAM-1, MMP-2 and VEGF-A were measured at 2 and 4 hours exposure by using RT-PCR, CytoMatrixTM kit and ECMatrixTM kit. The pretreated gastric cancer cells were injected into abdominal cavity of nude mice(2×106 cells per mouse). Five mice in each group were sacrificed 4 weeks later to record the number of tumor nodules in abdominal cavity. The remaining mice were kept for observation of survival time. Results The expression of E-cadherin (MKN-45: from 2.26 to 2.19, SGC-7901 :from 2.16 to 2.09、MKN-28 :from 2.06 to 1.99), ICAM-1 (MKN-45 : from 2.20 to 2.28、SGC-7901: from 2.10 to 2.18、MKN-28: from 2.00 to 2.08), MMP-2 (MKN-45:from 2.05 to 2.13、SGC-7901: from 1.95 to 2.03、MKN-28: from 1.85 to 1.93) and VEGF-A(MKN-45 : from 2.10 to 2.16、SGC-7901 :from 2.00 to 2.06、MKN-28: from 1.90 to 1.96) didn't change significantly with increasing pressure and time (P>0.05). The expression of adhesive and invasive molecules didn't change significantly between the experimental groups and the control group. There was no statistical significance of tumor metastasis in abdominal cavity of nude mice(MKN-45:from 22 to 23、SGC-7901 :from 20 to 22、MKN-28:from 21 to 22) and survival time(MKN-45 :from 23 to 21、SGC-7901 :from 22 to 21、MKN-28 :from 22 to 21) among all the groups. Conclusion Under low pressure and short time of CO2 exposure, the adhesive and invasive capacity of gastric cancer cells did not change significantly hence did not increase the possibility of neoplasm metastasis. 相似文献
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Objective To investigate the influence of CO2 pneumoperitoneum on the adhesive and invasive ability of gastric cancer cells based on the expression of adhesive and invasive molecules. Methods With an artificial CO2 pneumoperitoneum model in vitro, human gastric cancer cells MKN-45, SGC-7901 and MKN-28 were exposed to 3 different CO2 gradients: 9 mm Hg, 15 mm Hg and control group (0 mm Hg). The expression of E-cadherin, ICAM-1, MMP-2 and VEGF-A were measured at 2 and 4 hours exposure by using RT-PCR, CytoMatrixTM kit and ECMatrixTM kit. The pretreated gastric cancer cells were injected into abdominal cavity of nude mice(2×106 cells per mouse). Five mice in each group were sacrificed 4 weeks later to record the number of tumor nodules in abdominal cavity. The remaining mice were kept for observation of survival time. Results The expression of E-cadherin (MKN-45: from 2.26 to 2.19, SGC-7901 :from 2.16 to 2.09、MKN-28 :from 2.06 to 1.99), ICAM-1 (MKN-45 : from 2.20 to 2.28、SGC-7901: from 2.10 to 2.18、MKN-28: from 2.00 to 2.08), MMP-2 (MKN-45:from 2.05 to 2.13、SGC-7901: from 1.95 to 2.03、MKN-28: from 1.85 to 1.93) and VEGF-A(MKN-45 : from 2.10 to 2.16、SGC-7901 :from 2.00 to 2.06、MKN-28: from 1.90 to 1.96) didn't change significantly with increasing pressure and time (P>0.05). The expression of adhesive and invasive molecules didn't change significantly between the experimental groups and the control group. There was no statistical significance of tumor metastasis in abdominal cavity of nude mice(MKN-45:from 22 to 23、SGC-7901 :from 20 to 22、MKN-28:from 21 to 22) and survival time(MKN-45 :from 23 to 21、SGC-7901 :from 22 to 21、MKN-28 :from 22 to 21) among all the groups. Conclusion Under low pressure and short time of CO2 exposure, the adhesive and invasive capacity of gastric cancer cells did not change significantly hence did not increase the possibility of neoplasm metastasis. 相似文献
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目的:从细胞凋亡及自由基角度探讨麝香乌龙丸对兔实验骨折愈合的作用。方法:30只日本大耳白兔制成横断骨折模型,随机分为模型对照组、麝香乌龙丸组、骨折挫伤散组,灌胃给药。分别在骨折后24h、72h、1w、2w、3w、4w时检测血一氧化氮、乳酸、超氧化物歧化酶和丙二醛。结果:麝香乌龙丸在骨折后某时相能提高血超氧化物歧化酶水平,降低血乳酸、丙二醛水平,适时改变血一氧化氮水平,且优于骨折模型对照组(P<0.05)。结论:麝香乌龙丸通过影响细胞凋亡及自由基水平,达到缩短骨愈合时间,提高骨愈合质量,促进骨折愈合。 相似文献
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肝切除术前门静脉栓塞对围手术期影响的荟萃分析 总被引:1,自引:0,他引:1
目的:探讨肝切除术(有半肝、扩大半肝切除术)前应用门静脉栓塞(portal vein embolization,PVE)对病人围手术期的影响。方法:通过电子检索Pubmed、Medline数据库,对1986~2008年有关右半肝或扩大半肝切除术前行PVE病例的对照研究资料进行荟萃分析。结果:共纳入8篇文献.423例病人。荟萃分析结果显示.PVE手术组与单纯手术组比较,术前谷草转氨酶(AST)、总胆红素(TB)、凝血酶原时间(PT)、15min吲哚氰绿储留率(ICGR-15)及肿瘤最大直径两组间均无统计学差异(19〉0.05);术中输血、肿瘤Rn切除及手术时间两组间均无统计学差异(P〉0.05)。PVE手术组术后感染的发生率显著降低(P=0.002),但二者在术后出血、胆瘘、肾功能衰竭及术后住院时间的差异无统计学意义(P〉0.05)。结论:术前行PVE不能提高肝脏肿瘤的R0切除率,但能降低术后感染的发生率。 相似文献