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1.
Objective To investigate the effects of intensive insulin therapy on inflammatory re-sponse and prognosis of patients with severe trauma. Methods Eighty severely injured patients were di-vided into intensive insulin therapy group (n = 40, IT) and routine therapy group (n = 40, RT) in random pair. At the time of admission, a continuous infusion of insulin (2 -4 U/h) was pumped into the patients of IT group to maintain blood glucose level at 6 -8 mmol/L. Patients in RT group were given routine treatment without administration of insulin. Fever, organ injury, and mortality of patients in 2 groups were recorded. Venous blood was drawn from patients of 2 groups on the morning of post treatment day (PTD) 1, 3, 5, and 7. Values of TNF-α, C-reactive protein (CRP), IL-2, and IL-10 in plasma were assayed. Results High fever appeared in 9 patients in IT group, and WBC exceeded 10.0×109 for more than 3 days in 17 patients in this group, versus 20 and 29 patients respectively in RT group. Dysfunction of 1 organ appeared in 31 pa-tients in IT group and 30 patients in RT group. Dysfunction of 3 organs appeared in 10 patients in IT group and 19 patients in RT group. Dysfunction of 4 organs appeared in 7 patients in IT group and 12 patients in RT group. In IT group, 4 patients died within 3 post-injury day (PID), and 1 patient died after PID 3 (total case fatality: 12.5% ). In RT group, 5 patients died within 3 PID, and 4 patient died after PID 3 (total case fatality: 22.5%). Plasma levels of TNF-α and CRP of patients in IT group were significantly lower than those of patients in RT group on PID 3 - 7 ( P<0.05 or P<0.01 ), while levels of IL-2 and IL-10 of patients in IT group were significantly higher than those of patients in RT group ( P<0.05 or P<0.01 ). Plasma levels of TNF-α ( 1.3±0.6 μg/L) and CRP (55±16 mg/L) of patients in IT group on PTD 7 were lowered to the trough level, and they were significantly lower than those of patients in RT group (3.0±0.8μg/L, 89±20 mg/L, respectively, P <0.01 ). Conclusions Intensive insulin therapy can mitigate systemic inflammatory response and improve prognosis of patients with severe trauma. 相似文献
2.
目的研究大麻素WIN55,212—2对体外培养的牛眼小梁细胞前列腺素E2(PGE2)表达的影响,从而探讨其降眼压机制。方法采用组织块培养法对牛眼小梁细胞进行原代培养,取传3代的细胞运用酶联免疫吸附(ELISA)法测定不同浓度大麻素WIN55,212—2作用后细胞上清液中PGE2水平的变化;运用RT—PCR方法检测不同浓度大麻素WIN55,212—2作用后PGE2mRNA在小梁细胞内的表达水平。结果细胞上清液中的PGE2水平与细胞内PGE2mRNA水平随大麻素浓度变化呈剂量依赖性升高。结论一定剂量的大麻素可以促进小梁细胞分泌PGE2,从而达到降低眼压的目的。 相似文献
3.
目的了解慢性阻塞性肺疾病(COPD)稳定期患者家庭氧疗现状。方法对2016年6月至2017年8月在重庆市人民医院门、急诊及住院治疗的COPD患者共263例采用调查问卷的形式进行调查。结果263例调查者中对于氧疗的认识仅约10%的患者达到完全了解的程度,其中162例(61.60%)患者未实施氧疗,101例(38.40%)患者实施氧疗,但仅有11例患者每天吸氧时间大于15h达到指南的氧疗要求,且患者氧疗行为随意性大。结论 COPD患者对于COPD持续氧疗的优点及重要性的认识严重不足,急需广大医务工作者加大健康教育力度,寻求切实有效的方法改变COPD患者氧疗现状。 相似文献
4.
目的:探索循证护理在预防人工气道肺部感染中的应用。方法选取建立人工气道患者32例循证护理患者为循证护理组,急诊建立人工气道39例常规护理患者作为常规护理组,比较分析两组患者肺部感染发生率,临床肺部感染评分(CPIS)、前降钙素原(PCT)、C-反应蛋白(CRP)的差异。结果循证护理组肺部感染发生率、CPIS 评分、PCT、CRP 分别为6.25%、(41.01±8.22)mg/L、(0.06±0.12)mg/L、(1.16±0.36)分,显著低于常规护理组,差异有统计学意义(P <0.05)。结论循证护理能有效地预防人工气道患者肺部感染的发生。 相似文献
5.
目的探讨阿托伐他汀对脑梗死患者P-选择素、可溶性细胞间粘附因子-1(SICAM-1)、基质金属蛋白酶-9(MMP-9)的影响。方法选择105例脑梗死患者随机分为两组,分别给予阿托伐他汀和常规治疗,采用双抗体夹心法测定P-选择素、酶联免疫法测定SICAM-1、夹心酶联免疫吸附法测定MMP-9。结果阿托伐他汀治疗组三项指标浓度明显降低(P<0.05),常规治疗组无明显变化(P>0.05)。结论阿托伐他汀有抗炎及稳定粥样斑块作用。 相似文献
6.
患者 ,女 ,7岁 ,1997年 5月 6日 10 :0 0在武城县卫生防疫站接种门诊接受麻疹疫苗加强免疫 ,于左上臂三角肌附着处外侧缘皮下注射冻干麻疹疫苗 0 2ml(上海生物制品研究所生产 ,批号 96 0 4 5 4 ,效期 1997年10月 )。 5月 7日 8:0 0左右 ,患者恶心、呕吐数次 ,四肢、躯干、颈、面部均出现红色小皮疹 ,其家长带到附近个体诊所就诊 ,按“过敏”给予肌注地塞米松 2mg ,口服息斯敏 5mg。 5月 8日到县人民医院就诊 ,其皮疹较前明显增多 ,且大小不等融合成片 ,高起皮肤成紫斑 ,压之不褪色 ,紫斑间皮肤正常 ,口腔黏膜亦出现紫斑并破溃 ,患者… 相似文献
7.
Objective To investigate the effects of intensive insulin therapy on inflammatory re-sponse and prognosis of patients with severe trauma. Methods Eighty severely injured patients were di-vided into intensive insulin therapy group (n = 40, IT) and routine therapy group (n = 40, RT) in random pair. At the time of admission, a continuous infusion of insulin (2 -4 U/h) was pumped into the patients of IT group to maintain blood glucose level at 6 -8 mmol/L. Patients in RT group were given routine treatment without administration of insulin. Fever, organ injury, and mortality of patients in 2 groups were recorded. Venous blood was drawn from patients of 2 groups on the morning of post treatment day (PTD) 1, 3, 5, and 7. Values of TNF-α, C-reactive protein (CRP), IL-2, and IL-10 in plasma were assayed. Results High fever appeared in 9 patients in IT group, and WBC exceeded 10.0×109 for more than 3 days in 17 patients in this group, versus 20 and 29 patients respectively in RT group. Dysfunction of 1 organ appeared in 31 pa-tients in IT group and 30 patients in RT group. Dysfunction of 3 organs appeared in 10 patients in IT group and 19 patients in RT group. Dysfunction of 4 organs appeared in 7 patients in IT group and 12 patients in RT group. In IT group, 4 patients died within 3 post-injury day (PID), and 1 patient died after PID 3 (total case fatality: 12.5% ). In RT group, 5 patients died within 3 PID, and 4 patient died after PID 3 (total case fatality: 22.5%). Plasma levels of TNF-α and CRP of patients in IT group were significantly lower than those of patients in RT group on PID 3 - 7 ( P<0.05 or P<0.01 ), while levels of IL-2 and IL-10 of patients in IT group were significantly higher than those of patients in RT group ( P<0.05 or P<0.01 ). Plasma levels of TNF-α ( 1.3±0.6 μg/L) and CRP (55±16 mg/L) of patients in IT group on PTD 7 were lowered to the trough level, and they were significantly lower than those of patients in RT group (3.0±0.8μg/L, 89±20 mg/L, respectively, P <0.01 ). Conclusions Intensive insulin therapy can mitigate systemic inflammatory response and improve prognosis of patients with severe trauma. 相似文献
8.
目的分析影响中药成方制剂疗效的因素。方法通过收集有关资料及生产经验,寻找影响中药成方制剂疗效的相关因素。结果影响中药成方制剂疗效的因素是多方面的,从原药材-生产-使用都息息相关。结论为了保证药品的安全、有效,必须严格控制质量,合理用药。 相似文献
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