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目的 探讨肺结核与肺癌的相关性。方法 运用经典抗酸染色 (ZN法 )、改良抗酸染色(IK法 )、免疫组织化学染色 (ABC法 )及TB PCR方法对 3 3 0例肺癌患者结核菌感染状况进行了前瞻性研究。结果 全组 3 3 0例纤维支气管镜刷检结核菌阳性率为 2 7.88% ;93例肺癌组织标本IK法结核菌阳性率 3 8.71% ,ABC法阳性率 5 1.6 1% ;14例手术切除标本结核菌培养阳性率 5 7.14 % ;2 0例肺癌组织切片TB PCR阳性率 6 0 %。结论 肺癌患者结核菌特别是它的L型有较高的感染率。提示肺结核与肺癌之间可能有一定的相关性。 相似文献
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肺癌的发病率和死亡率呈逐年增长趋势,其中绝大多数是非小细胞肺癌(NSCLC),且一半以上就诊时已是ⅢB或Ⅳ期,化疗是这类患者主要治疗手段,但五年生存率仅5%~11%。如何延迟这类患者的复发时间和延长生存时间?维持治疗成为了近年研究热点之一,本文对NSCLC维持治疗的研究进展进行综述。 相似文献
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Objective To investigate the influence of simvastatin on inflammatory indices in nasal lavage,sputum and blood and clinical index in patients with chronic obstructive pulmonary diseases (COPD). Methods Thirty-seven stable COPD patients were randomly divided into simvastatin-treatment group (n=17),orally given simvastatin tablets for 4 weeks in addition to basic therapy,40 mg,qd) and control group (n=20),given usual med-ication). Total cell counts,percentage of leukocytes (N%) and levels of interleukin IL-8,IL-6 in nasal lavage and sputum at pre-post-treatment were compared;Serum C-reactive protein (CRP),total cholesterol (TC),low-density lipoprotein-cholesterol (LDL-C) as well as IL-8,IL-6 concentrations were measured,the variation of lung function,Sino-Nasal Outcome Test 20(SNOT-20) and St George's Respiratory Questionnaire(SGRQ) score were analyzed. Results After the treatment,the nasal lavage and sputum total cell counts,N%,IL-8 and IL-6 levels[nasal lavage: (0.7±0.3)×107/L,(41.1±10.9)%,(105.8±74.5) ng/L,(3.8±1.6) ng/L;sputum: (0.8±0.3)×109/L,(56.6±9.6) %,(2565.5±831.9) ng/L,(109.8±42.3) ng/L] dropped slightly in the simvastatin group com-pared with that at pretreatment [nasal lavage: (0.8±0.3)×107/L,(43.2±10.8) %,(107.6±86.3) ng/L,(4.1±1.9)ng/L;sputum: (0.8±0.3)×109/L,(58.1±9.3)% ,(2659.4±885.2) ng/L,(111.8±46.6) ng/L] (P>0.05) ;There were significant decreases in serum CRP [(4.3±3.7) mg/L vs (2.6±1.8) mg/L],IL-6 [(4.8±2.0)ng/L vs(4.7±1.9)ng/L] ,TC[(4.2±1.0) mmol/L vs(3.7±0.8)mmol/L] ,LDL-C[(2.4±0.5) mmol/L vs (2.2±0.5)mmol/L] (P>0.05) ;IL-8 concentrations in serum were lower gently[(6.2±1.8) ng/L vs (6.4±1.9) ng/L] (P>0.05). Significant change of simvastatin treatment on SGRQ was only reflected in the symp-tom score [pre-post-treatment:39.6±10. 8 vs 32.3±11.6,P<0.05,respectively],while other observation items (SNOT-20,FEV1%,FEV1/FVC) changed not notably (P>0.05). No marked changes in inflammatory markers and quality of life scores,lung function were observed in control group (P>0.05). Conclusion Simvastatin may be as-sociated with the potential to alleviate systemic inflammation and relieve symptoms in COPD patients. 相似文献
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肺癌是目前世界上最常见的恶性肿瘤之一,其生存及预后极差,已成为我国恶性肿瘤死亡原因的第一位。现代医学角度分析,肺癌可分为小细胞肺癌(SCLC)和非小细胞肺癌(NSCLC)。NSCLC是指SCLC以外的所有类型的肺癌,约占所有肺癌的75%-80%。非小细胞型肺癌与小细胞癌相比其进展相对较慢,扩散转移相对较晚,恶性程度相对偏低,但约75%的患者发现时已处于中晚期,5年生存率普遍偏低. 相似文献
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肺结核患者结核分支杆菌L型的检测及临床意义 总被引:6,自引:2,他引:4
对象与方法收集蚌埠医学院附属医院呼吸内科门诊及住院初治肺结核有痰患者102例,男68例,女34例,平均年龄45(16~80)岁,所有病例均行PPD试验。对以上病例痰液标本行下列检测:(1)经典抗酸染色(ZN法)。(2)改良抗酸染色(IK法),其操作及... 相似文献
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一、对象与方法1.1993~1996年蚌埠医学院在纤维支气管镜(纤支镜,OlympusBFB3R型)检查时,取活检标本行改良抗酸染色法(IK法)及免疫酶染色法(ABC法)共160例,其中老年患者60例,年龄60~74岁,男48例,女12例;非老年患... 相似文献
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哮喘患者血浆VIP水平的观察 总被引:3,自引:3,他引:0
目的:观察哮喘患者发作期与缓解期血浆中血管活性肠肽(VIP)水平改变,以探讨VIP在哮喘发病中的可能作用。方法:应用放射免疫分析法检测27例发作期和21例缓解期哮喘患者血浆VIP与ET含量,并对肺功能进行监测。结果:哮喘发作期血浆VIP与ET水平分别为30.4±8.4pg/ml和58.2±11.6pg/ml,分别显著低于和高于正常对照组(p<0.05)。哮喘缓解期VIP、ET水平与对照组相比无显著性差异。尤其在ET水平<51.7pg/ml的12例发作期患者,血浆VIP水平为27.3±7.5pg/ml,显著低于对照组(p<0.01),并与所测FEV1%下降呈正相关(r=0.73,p<0.01)。结论:体内VIP水平低下所致的调节作用减弱、气道舒缩状态的紊乱可能在哮喘的发病中具有重要意义。 相似文献