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随着电镜技术在体外培养细胞实验中的应用,促使人们寻求一种能保持培养细胞在自然生长状态时的超微结构研究手段,这要求在细胞固定、脱水、包埋等一系列操作中都要在理想的条件下进行。虽然前人在细胞 相似文献
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It has been known that the antimalarial drugs of aminoquinolinesincluding 8-aminoquinolines may cause inhibition of heart conduction or evenAdams-Stokes syndrome,but their morphologic bases were obscure.The purposeof the present study is to define the histological and ultrastructural features ofprimaquine in mammals including dogs,monkeys and rats in the subacute toxicexperiments with the stress on the morphological alteration of the heart.In most(11/16)of the intoxicated dogs,granular degeneration,eosinophilic degeneration,coagulation necrosis,vacuolar degeneration and colliquative myocytolysis werefound in the myocardium and conduction systems.Under electron microscopicstudy,the myocardial cells of intoxicated dogs showed swelling of mitochondria,dilatation of transverse tubules and sarcoplasmic reticulum,fusion or dissolutionof myofibrils,deformity of nuclei,clumping of chromatin,and eventually cellnecrosis.The severities of lesions were dose dependent.These lesions weresupposed to be the morphologic evidence of the toxic symptoms and signs caused byprimaquine.A few rats also revealed myocardial eosinophilic degeneration.Noimportant cardiac lesions were found in the monkeys,but the pathologic changesin the liver were obvious.Different species of laboratory animals showed differentorgan sensitivities to primaquine,but the heart lesions should be considered as animportant toxic effect of primaquine. 相似文献
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本文报道5-对氟苯氧基伯喹柠檬酸盐(NP0090)和伯喹亚急性毒性试验中42只狗和6只猴的大体解剖和脏器显微镜检查的病理形态学观察的结果,其中以心、肝作为重点。 相似文献
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病史摘要 患者,男性,42岁,工人,1985年10月患者以何杰金氏淋巴瘤住本院血液科,用COP方案治疗3个疗程,病情好转,出院后继续化疗。1986年1月5日起发热38.5℃,畏寒、乏力、尿黄、纳差、恶心呕吐,用灭吐灵,维生素B_6等对症治疗,上述症状未减轻,并出现腹痛、腹泻粘液便,11日停止化疗。23日仍发热,腹胀,巩膜微黄,腹软,肝不 相似文献
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猝死型胰腺炎,又称无痛性急性坏死性胰腺炎(Painless acute necrotic pancreatit-is),是急性胰腺炎的一种特殊表现类型,临床并非少见。早在1954年Williams即首先报道了急性坏死性胰腺炎是猝死的一个原因。国内自1966年张伟报道17例以来,迄今为止,已有多组大样本报道,为了提高临床对猝死型胰腺炎的认识,特将其基础与临床作一介绍。一、发病率:猝死型胰腺炎多发生于青壮年,男性明显多于女性,一般占猝死病例的10~20%左右,是青壮年猝死的主要原因之一,因此,猝死型胰腺炎在急救医学方面极为重要。二、病因和病程:与一般急性胰腺炎病因相同,饱食、饮酒、食高脂饮食、胆源性疾病等均可诱发本病。在我们的报道中,情绪因素起重要 相似文献
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17例肝脏炎性假瘤的临床病理分析 总被引:12,自引:1,他引:11
本文对17例肝脏炎性假瘤的临床病理特点进行了分析。结果显示该病的主要特点是:发病年龄较轻,平均37.2岁;男性多见,占82.4%;近65%的患者无特殊病史;76.5%的患者具有以右上腹隐痛为主的临床症状;病程较短,中位时间3个月;82.4%的结节为单个,并有完整包膜;结节体积多较小,平均直径3.8cm(中位数3.2cm);发生部位以肝右叶多见,占76.5%;病变以炎性增生性纤维组织为基本结构。本文对该病的病因及鉴别诊断进行了讨论。 相似文献