经皮耳迷走神经刺激干预功能性消化不良模型大鼠的效应及机制研究

ObjectiveTo explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation (taVNS) for the functional dyspepsia (FD) model rats.MethodsOf the 25 male SD rats, 6 rats were set as blank group, the other 19 rats were established to be the functional dyspepsia (FD) model by iodoacetamide intragastric administration, and 18 FD models were successfully established. The 18 model rats were randomly divided into a model group, a sham-taVNS group, and taVNS group, with 6 rats in each group. There was no intervention applied to the rats in the blank and model groups. Whereas, the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides, and those in taVNS group received stimulation to the cavity of auricular concha of both sides, for 30 min each time, once a day, 7 days in succession. After the intervention, the gastric sensitivity of the rats in each group under different pressure conditions in the stomach, the expressions of serum brain-gut peptide motilin (MTL), cholecystokinin (CCK), glucagon-likepeptide1 (GLP-1), and inflammatory factors IL-4, IL-10, and IL-1β were detected.Results(1) Gastric sensitivity: compared with the blank group, the gastric sensitivity of the model group was higher (P <0.05). Compared with the model group, the gastric sensitivity of the taVNS group was lower (P < 0.05). Compared with the sham-taVNS group, the gastric sensitivity of the taVNS group was lower (P <0.05).(2) Expression of brain-gut peptide: compared with the blank group, MTL was lower, CCK and GLP-1 were higher in the model group (all P <0.05). Compared with the model group, MTL was higher, CCK and GLP-1 were lower in the taVNS group (all P <0.05). Compared with the sham-taVNS group, CCK and GLP-1 were lower in the taVNS group (both P<0.05). (3)Expression of inflammatory factors: compared with the blank group, IL-4 and IL-10 were lower and IL-1β was higher in the model group (all P <0.05). Compared with the model group, IL-10 was higher and IL-1β was lower in the sham-taVNS group (all P <0.05), while IL-4 and IL-10 were higher and IL-1β was lower in the taVNS group (all P <0.05). Compared with the sham-taVNS group, IL-4 and IL-10 were higher and IL-1β was lower in the taVNS group (all P <0.05).ConclusionTaVNS can reduce the gastric sensitivity of FD model rats by peripheral anti-inflammatory action and regulating the abnormal secretion of brain-gut peptide.     

经皮耳迷走神经刺激干预功能性消化不良模型大鼠的效应及机制研究（英文）

Objective:To explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation(taVNS) for the functional dyspepsia(FD) model rats.Methods:Of the 25 male SD rats,6 rats were set as blank group,the other 19 rats were established to be the functional dyspepsia(FD) model by iodoacetamide intragastric administration,and 18 FD models were successfully established.The 18 model rats were randomly divided into a model group,a shamtaVNS group,and taVNS g...     

基于功效古今演变的艾叶研究进展与应用思考

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针刺治疗脑损伤后的痉挛状态研究概述

脑损伤后痉挛状态是脑损伤引发的,以大脑皮层为主的高级中枢丧失调控随意性运动的能力,产生由低级中枢控制的肌张力增高及协调能力失常的异常运动模式。脑损伤是世界范围内发病率和死亡率较高的疾病,而脑损伤后的痉挛状态是一种常见的并发症,严重影响患者的生活质量,且尚无有效的神经保护药物,而针刺具有促进神经重塑及缓解痉挛的作用,为临床治疗脑损伤提供一种可行方法。研究已证明各类针刺方法对脑损伤后痉挛状态有积极作用。该文将阐述脑损伤后痉挛状态的发病病机,不同针刺方法对脑损伤后痉挛状态的改善作用,并对目前存在的问题及未来研究方向进行展望。     

象思维视域下的命门形质内涵与现代价值探讨

自《黄帝内经》首论命门以来,历代医家对命门有许多不同的阐述,以探讨“命门”形象和功能作用为众。中国传统思想理论的建构受“象”思维影响,以“象”探讨命门,阐发命门之“形”。构建以“肾-命门”为核心的传统医学内涵。融汇各家学说,从“枢”的角度分析命门的中心特点,认为神经内分泌免疫网络(NEI网络)为现代医学表现的命门形象,用中医整体观看待NEI网络,发掘命门类药物对NEI网络的调节作用,探索出以NEI网络为基础发挥命门对肾病综合征、心功能不全、骨质疏松综合征等疾病乃至全身微环境整体调控的现代价值。