小儿豉翘清热颗粒联合利巴韦林治疗儿童病毒性上呼吸道感染临床观察

目的:观察小儿豉翘清热颗粒联合利巴韦林治疗儿童病毒性上呼吸道感染的临床疗效。方法:选取100例病毒性上呼吸道感染患儿,按照随机数字表法分为实验组和对照组,每组50例。对照组予利巴韦林颗粒治疗,实验组在此基础上加用小儿豉翘清热颗粒,2组均治疗5天。评估2组临床疗效,记录患儿退热时间及咳嗽、鼻塞、咽喉红肿消失时间。结果:实验组总有效率100%,对照组总有效率100%,2组比较,差异无统计学意义(P0.05)。实验组退热时间及咳嗽、鼻塞、咽喉红肿的消失时间均短于对照组,差异均有统计学意义(P0.05)。结论:小儿豉翘清热颗粒联合利巴韦林治疗儿童病毒性上呼吸道感染,可有效缩短患儿临床症状的消失时间。     

肠猪带绦虫感染致肠梗阻1例

1病历介绍 患者，女，30岁，2006年4月14日因脐周阵发性疼痛伴恶心、呕吐2周入院。患者曾经在福建医科大学附属第一医院住院，考虑为腹痛待查，查胃镜、肠镜无明显异常发现，治疗10^＋d（具体不详），症状无缓解来我院。入院后查立位腹部平片示不全性肠梗阻可能，肠系膜动脉造影未见明显异常，予赛嘧啶驱虫2d，禁食、抗炎、温肥皂水灌肠治疗，腹痛不缓解，但偶然发现大便中有2条白色长条虫样物。     

耻骨后保留尿道前列腺切除术52例报告

应用耻骨后保留尿道前列腺切除术治疗前列腺增生症５２例。本术式保留了尿道和精道的完整性。结果所有患者术后首镒排尿均通畅，无尿失禁，血尿或仅有轻度血尿，无需膀胱冲洗，留置导管时间短。术后２周尿流动力学检查，每次尿量２１０－４３０ｍｌ，平均尿流率１２－１５ｍｌ／ｓ，Ｂ超测定残余尿量３－１０ｍｌ。     

乳铁蛋白对机体免疫功能的影响

乳铁蛋白(1actoferrin,IS)是一种非血红素铁结合性糖蛋白,在乳腺分泌物中含量丰富.最初发现它具有转运体内铁以及通过调节机体免疫起到广谱抗菌抗病毒作用.近年研究进一步发现,乳铁蛋白作为免疫佐剂可辅佐卡介苗刺激机体巨噬细胞产生白介素-12等加强迟发型变态反应从而提高卡介苗接种效率;通过调节T淋巴细胞等细胞免疫功能参与肿瘤免疫.此外,乳铁蛋白具有对免疫修复的正向调节作用.文章就乳铁蛋白对机体黏膜免疫、肿瘤免疫、变态反应以及免疫修复方面的影响作一综述.随着对乳铁蛋白免疫调节机制的进一步深入研究,其作为免疫调节制剂将越来越广泛地应用于临床.     

90例联合用药治疗小儿腹泻疗效观察

目的：观察常规用药联合思密迭治疗小儿腹泻的临床疗效,为小儿腹泻的临床诊治提供参考依据。方法：筛选我院自2007年1月至今收治的90例经确诊为腹泻的患儿,随机分为治疗组和对照组。两组均常规给予补液、抗病毒等常规治疗,而治疗组在此基础上联合使用思密达治疗,比较分析两组患儿治疗后的效果。结果：治疗组的显效率为32．6％、改善率为91．3％,而对照组的显效率与改善率分别为16．0％、51．4％,两组结果比较具有显著性的差异（P〈0．05）。结论：常规治疗联合思密迭治疗小儿腹泻相比于常规用药治疗具有显著的疗效,没有明显的不良反应,疗效／可靠,值得推广。     

闭合性肾损伤72例诊治体会

闭合性肾损伤７２例诊治体会王景玉程德勇韩汝政莱钢总厂医院泌尿外科（２７１１２６）我院于１９８８～１９９６年共收治闭合性肾损伤７２例，现将诊治体会报告如下。１临床资料１１一般资料本组７２例中，男５８例，女１４例。年龄４～６０岁，平均３７５岁，其中２...     

乳铁蛋白对新生SD大鼠T细胞及肠道黏膜发育的影响

目的 研究乳铁蛋白对新生SD大鼠T细胞及肠道黏膜发育的影响.方法 将96只新生SD大鼠随机分为12组,每组8只,分别给予1.0(Ⅰ剂量组)、3.0(Ⅱ剂量组)、5.0 g·kg-1·d-1(Ⅲ剂量组)乳铁蛋白和2、3、4周喂养,并设相应对照.分别于喂养第2、3、4周处死相应喂养剂量组大鼠,采用免疫荧光法测定大鼠静脉血CD4+T和CD8+T淋巴细胞水平;取大鼠空肠及回肠各1 cm制作病理切片,采用图像分析系统观测肠道绒毛高度、周长、面积和隐窝深度.结果 喂养2周时,Ⅰ、Ⅱ剂量组大鼠的CD4+T淋巴细胞水平明显高于对照组(P均＜0.05),Ⅱ、Ⅲ剂量组大鼠的CD8+T淋巴细胞水平明显高于对照组(P均＜0.05);空肠绒毛高度、周长、面积及隐窝深度在各剂量组与对照组间总的差异无统计学意义(P均＞0.05);回肠绒毛高度、隐窝深度、绒毛周长及面积在各剂量组与对照组间总的差异有统计学意义(P均＜0.05).喂养3周时,3个剂量组大鼠的CD4+T淋巴细胞水平均明显高于对照组(P均＜0.05),Ⅲ剂量组大鼠的CD8+T淋巴细胞水平明显高于对照组(P＜0.05);空肠及回肠绒毛高度、隐窝深度、绒毛周长及面积在各剂量组与对照组间总的差异均有统计学意义(P均＜0.05).喂养4周时,3个剂量组大鼠的CD4+T淋巴细胞水平均明显高于对照组(P均＜0.05),Ⅱ、Ⅲ剂量组大鼠的CD8+T淋巴细胞水平明显高于对照组(P均＜0.05);回肠绒毛面积各剂量组与对照组间总的差异无统计学意义(P＞0.05);空、回肠绒毛高度、隐窝深度、绒毛周长及空肠绒毛面积各剂量组与对照组间总的差异均有统计学意义(P均＜0.05).结论 乳铁蛋白对新生大鼠CD4+和CD8+T淋巴细胞及空、回肠黏膜发育有促进作用,其作用受乳铁蛋白喂养剂量及时间的影响.

Abstract：

Objective To explore the effects of lactoferrin on T cells ( the levels of CD4 + T and CD8 +T lymphocytes) and the development of intestinal mucous membrane (villus heights, crypt depths, villus circumferences, and villus areas) in neonatal SD rats. Methods Totally 96 neonatal (one week old) SD rats were equally and randomly divided into twelve groups, in which animals were fed with lactoferrin at a dose of 1.0 g/( kg · d) (dose Ⅰ group), 3.0 g/(kg · d) (dose Ⅱ group), or 5.0 g/(kg · d) (dose Ⅲ group) for 2, 3, or4 weeks,with corresponding blank control groups. Rats in the dosage groups were killed at the set time points and the levels of venous blood CD4 + and CD8 + T lymphocytes were detected using immunofluorescence method. Jejunum ( 1 cm)and ileum (1 cm) specimens were obtained for pathological sectioning, and the villus height, crypt depth, villus circumferences, and villus areas were measured through image analysis system. Results The CD4 + T lymphocyte levels at two weeks were significantly different among dose I group, dose Ⅱ group, and control groups ( all P ＜0. 05).The CD8 + T lymphocyte levels at two weeks were significantly different among dose Ⅱ group, dose Ⅲ group,and control groups ( all P ＜ 0. 05 ). The villus heights, crypt depths, villus circumferences, and villus areas of jejunum at two weeks between feeding groups and control groups were not significantly different ( all P ＞ 0. 05 ), while the condition in ileum was on the contrary. The CD4 + T lymphocyte levels at three weeks were significantly different between feeding groups and control groups ( P ＜ 0. 05 ). The CD8 + T lymphocyte levels at three weeks between dose Ⅲ group and control groups were significantly different ( P ＜ 0. 05 ). The villus heights, crypt depths, villus circumferences, and villus areas of jejunum and ileum at three weeks were significantly different between feeding groups and control groups ( all P ＜ 0. 05 ). The CD4 + T lymphocyte levels at four weeks between feeding groups and control groups were significantly different (P ＜0. 05). The CD8 + T lymphocyte levels at four weeks were significantly different among dose Ⅱ group, dose Ⅲ group, and control groups ( all P ＜ 0. 05 ). Except villus areas of ileum, the villus heights, crypt depths, villus circumferences of jejunum and ileum, and villus areas of jejunum at four weeks were significantly different between feeding groups and control groups ( all P ＜ 0.05 ). Conclusions Lactoferrin can promote the levels of CD4 + and CD8 + T lymphocytes in venous blood and facilitate the development of the mucous membranes of jejunum and ileum. However, such effects are affected by the dose and timing of lactoferrin feeding.     

双黄连口服液联合利巴韦林颗粒治疗小儿上呼吸道感染临床观察

目的:观察双黄连口服液联合利巴韦林颗粒治疗小儿上呼吸道感染的临床疗效。方法:选取100例上呼吸道感染患儿为研究对象,随机分为试验组和对照组各50例。试验组予双黄连口服液联合利巴韦林颗粒治疗,对照组单纯采用利巴韦林颗粒治疗。治疗后比较2组临床疗效,观察患儿临床症状的改善情况及不良反应发生情况。结果:试验组总有效率96.0%,对照组总有效率80.0%,2组比较,差异有统计学意义(P0.05)。试验组发热、咽红、恶寒、鼻塞流涕、咳嗽、泛恶及喷嚏的改善情况均优于对照组,差异均有统计学意义(P0.05)。2组不良反应发生率比较,差异无统计学意义(P0.05)。结论:双黄连口服液联合利巴韦林颗粒治疗小儿上呼吸道感染安全有效,能显著改善患儿的症状。     

手术治疗逆行射精1例

病例报告　患者男 ,2 8岁。因“婚后 2年不育”来诊。患者于 4年前有膀胱颈部外伤史 ,经手术治疗后痊愈。婚后性生活正常 ,有射精感但无精液排出。女方生殖系统查体未见异常。入院查体 :阴茎 ,睾丸发育正常 ,全尿道造影未见狭窄 ,性高潮后尿液镜检发现大量精子。入院诊断“逆行射精”。于 1 997年 2月在硬膜外麻醉下行“膀胱颈部重建术”。手术方法 :切开膀胱后 ,围绕膀胱颈部做一倒“Ｕ”形粘膜切口 ,分离粘膜达尿道前列腺部约 1ｃｍ并切除 ,显露膀胱颈部肌肉 ,切除瘢痕组织 ,自尿道外口插入Ｆ1 6号Ｆｏｌｅｙ′ｓ尿管一根 ,用 0号铬制肠线…