扶阳罐对阳虚质亚健康人群疗效观察

目的:观察扶阳罐和铺灸对阳虚质亚健康人群调理作用。方法:选择受试者60例,随机分为试验组(扶阳罐组)和对照组(铺灸组)并进行调理。结果:试验组总有效率为93.33%,明显优于对照组73.67%,2组阳虚质亚健康人群治疗前后在SF-36量表以及中医证候量表存在显著差异,但试验组各项指标显著优于对照组,且差异显著,P0.05,统计学有意义。结论:研究结果表明,试验组总有效率明显高于对照组,扶阳罐对阳虚质亚健康人群的调理效果更为显著。     

Clinical observation of warm needling moxibustion plus flash cupping for remission-stage peripheral facial paralysis due to wind-cold

Objective

To observe the clinical efficacy of warm needling moxibustion plus flash cupping for remission-stage peripheral facial paralysis (FP) due to wind-cold.

Methods

Fifty eligible patients were randomized into a warm needling moxibustion group and an acupuncture-cupping group, 25 cases in each group. The warm needling moxibustion group was intervened by acupuncture at Fengchi (GB 20), Yangbai (GB 14) towards Yuyao (EX-HN 4), Xiaguan (ST 7), Dicang (ST 4) towards Jiache (ST 6), Quanliao (SI 18), and Hegu (LI 4), plus warm needling moxibustion at Quanliao (SI 18); the acupuncture-cupping group received flash cupping on the affected side in addition to the intervention given to the warm needling moxibustion group. The two groups were both treated once a day, 10 times as a treatment course, for 3 courses in total. The House-Brackmann (H-B) facial nerve grading system was observed before and after the intervention to evaluate the facial nerve function in the two groups, and the therapeutic efficacies were also compared between the two groups.

Results

The two treatment protocols both can promote the recovery of facial nerve function. The total effective rate was 92.0% in the acupuncture-cupping group versus 72.0% in the warm needling moxibustion group, and the between-group difference was statistically significant (P<0.05).

Conclusion

Warm needling moxibustion plus flash cupping can produce a more significant efficacy than dry warm needling moxibustion in treating remission-stage peripheral FP due to wind-cold.

     

肿瘤出芽和TILs与结直肠癌患者临床病理特征和预后的相关性北大核心

目的:研究不同数量及比例的肿瘤出芽(tumor budding,TB)、肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes,TILs)在结直肠癌中的临床病理意义。方法:收集193例结直肠癌患者的肿瘤切片和临床资料,在HE染色下观察肿瘤出芽及TILs水平,并分析肿瘤出芽、TILs、出芽TILs联合分组与患者临床病理特征和预后的关系。结果:在结直肠癌患者中,肿瘤出芽与TNM分期、肿瘤解剖分期、分化程度、脉管侵犯、神经侵犯和预后相关(P<0.05);TILs与性别、TNM分期、肿瘤解剖分期、分化程度、神经侵犯、伴黏液腺癌和预后相关(P<0.05);出芽TILs联合分组与TNM分期、肿瘤解剖分期、分化程度、脉管侵犯、神经侵犯和预后相关(P<0.05),低出芽+高TILs组总生存期最长,高出芽+高TILs组次之,低出芽+低TILs组再次之,高出芽+低TILs组总生存期最短;肿瘤浸润淋巴细胞水平与肿瘤出芽水平呈负相关。结论:不同水平的肿瘤出芽、TILs、出芽TILs联合分组均能反映结直肠癌侵袭转移能力及预后,且出芽TILs联合分组相比肿瘤出芽和TILs对预后有更精细的评估。     

Effect of acupuncture plus thunder-fire moxibustion on MMP-3, TIMP-1 and TGF-β1 in rats with knee osteoarthritis

Objective

To observe the effect of acupuncture plus thunder-fire moxibustion on the expressions of matrix metalloproteinase-3 (MMP-3), tissue inhibitor of metalloproteinase-1 (TIMP-1) and transforming growth factor-β1 (TGF-β1) in cartilage of knee osteoarthritis (KOA) rats, and to explore the mechanism of acupuncture plus thunder-fire moxibustion in the treatment of KOA.

Methods

Thirty Sprague-Dawley (SD) rats were randomly divided into a blank control group, a model group and an acupuncture-moxibustion group by random digits table, 10 rats in each group. Rats in the model group and the acupuncture-moxibustion group were injected with papain in the right posterior knee joint to prepare the models. The levels of MMP-3 and TIMP-1 in rat synovium of each group were measured by enzyme-linked immunosorbent assay (ELISA) after 2 weeks of treatment. The level of TGF-β1 was determined by Motic B5 Micro-camera system.

Results

The levels of MMP-3 and TIMP-1 in the cartilage of the model group were significantly higher than those in the blank control group (all P<0.01); the levels of MMP-3 and TIMP-1 in the acupuncture-moxibustion group were lower than those in the model group, and the between-group differences were statistically significant (all P<0.05). The levels of MMP-3 and TIMP-1 in the acupuncture-moxibustion group were higher than those in the blank control group, and the differences were statistically significant (all P<0.05). The level of TGF-β1 in cartilage tissues of the model group was significantly lower than that in the blank control group (P<0.01); the level of TGF-β1 in the acupuncture-moxibustion group was higher than that in the model group (P<0.05), but it was lower than that in the blank control group, and the between-group difference was statistically significant (P<0.05).

Conclusion

Acupuncture plus thunder-fire moxibustion can effectively recover the abnormal expressions of MMP-3 and TIMP-1 in KOA model rats and somewhat up-regulate TGF-β1, which may be one of its mechanisms of acupuncture plus thunder-fire for KOA.