MORPHOLOGICAL CHANGES INDUCED BY RADIX ET RHIZOMA RHEI IN WISTAR RATS

This paper reports the experimental results oftwo batches of 24 male Wistar rats.In each batch,13 rats were controls and 11 were given Radixet Rhizoma Rhei decoction in 200% concentration(1.5 ml twice a day for 4 days for the first batchand 2.5 ml mornings and 2.0 ml afternoons for 10days for the second batch).The controls were giventhe same amount of distilled water.Histologicalexaminations showed that the lymphoid organs ofthe experimental animals including thymus,spleen,mesenteric lymph nodes and Peyer's patches weremuch smaller than those of the controls,particularlythe thymus.The white pulp of the spleen wasatrophied to various degrees.On the other hand,the adrenal glands of the experimental rats werelarger than those of the control animals.No obviouschanges were seen in other organs.The resultsshowed that Radix et Rhizoma Rhei appeared tohave selective inhibitive effect on the immune organsin Wistar rats.     

党参与抗癌药物配伍对肿瘤和荷瘤动物作用的实验研究

本实验系观察党参与环磷酰胺配伍对瑞士小白鼠皮下移植的 Lewis 肺癌和其肺转移灶以及荷瘤小鼠存活时间的作用。结果表明它不仅使实验动物开始死亡时间推迟,平均存活时间延长,而且使动物半数死亡时间(LT_(50))和全部死亡时间均延长,日存活率也提高。对肿瘤体积和重量的抑制均有统计学意义,也明显减少肺转移灶,这些效果均优于单独使用环磷酰胺。     

用过劳和饮食失节法塑造大白鼠脾气虚证模型的研究——生化免疫病理和超微结构观察

我们以劳倦伤脾、劳则气耗以及饮食失节脾胃乃伤等中医基础理论为指导,以劳倦伤脾为主,佐以饮食失节、甘肥过度塑造大白鼠脾气虚证,并对此造模动物进行了生物化学、免疫学,病理形态学和电镜等各项指标的观察。现将观察结果报道如下。