血府逐瘀汤治疗心律失常192例疗效观察

心律失常是心内科常见病、多发病,我们自2000年7月～2005年3月用血府逐瘀汤治疗心律失常患者192例,并设204例的对照观察组,疗效较好,现总结报道如下。     

冬病夏治、夏病冬治机理探微

"冬病夏治,夏病冬治"是中医学的一种特殊治疗方法.冬病夏治适用于病情冬重夏轻,夏病冬治适用于夏重冬轻的慢性衰弱性疾病.冬重夏轻者,素体阳虚;夏重冬轻者,素体阴虚.这两类阴阳各适其偏的特殊体质,古代就存在:有的人"能春夏不能秋冬",有的人"能秋冬不能春夏"(语出<灵枢>,"能"通"耐").那么,为什么这两种体质的病人要采用"冬病夏治,夏病冬治"方可以获得较佳的疗效呢?这要从"春夏养阳,秋冬养阴"的养生防病法则谈起.     

Experimental study on the apoptosis of the astrocytes and the oligodendrocytes induced by Ca^2＋ reperfusion

OBJECTIVE: To investigate the apoptosis rules of the astrocytes and oligodendrocytes induced by Ca(2+) reperfusion. METHODS: The apoptosis of purified cultured astrocytes and oligodendrocytes induced by Ca(2+) reperfusion and the relationship between the development of the cell apoptosis and post-reperfusion time was observed. RESULTS: Both the astrocytes and oligodendrocytes were obviously in a time-dependent fashion, and the apoptosis ratios of the oligodendrocytes (39.73%+/-4.16%) were higher than the astrocytes (19.64%+/-4.67%) 24 hours after Ca(2+) reperfusion. The TUNEL positive cells were 13.6+/-1.82 and 21.4+/-1.95 at every visual field of astrocytes and oligodendrocytes respectively 24 hours after Ca(2+) reperfusion. CONCLUSIONS: The astrocytes and oligodendrocytes are similar wi th the development rules on apoptosis and have different susceptiveness to the situation.     

阳和汤加味治疗病毒性心肌炎室性早搏34例

阳和汤具有温阳补血、散寒通滞之功，向为外科所习用。近年来，笔者以本方加味治疗病毒性心肌炎室性早搏34例，收到了较好效果，现报道如下。     

基于透皮离子导入技术的戒烟药物金雀花碱的可控递送研究

目的 探索烟碱乙酰胆碱受体部分激动剂金雀花碱(cytisine,CTS)经阳极离子导入透过离体猪皮。方法 采用HPLC-PDA建立并验证CTS的分析方法。研究了电流密度、药物浓度和药物基质对CTS透皮离子导入的影响。采用标志物对乙酰氨基酚解析CTS离子导入过程中电迁移和电渗的贡献。结果 CTS从水溶液中被动透皮不佳,但在离子导入条件下CTS的透皮递送量显著增加,将电流密度从0.15 mA·cm^–2增加到0.5 mA·cm^–2可使离子导入CTS的稳态流量呈线性增加(J=452.8I+31.51,r=0.998 3)。在使用0.5 mA·cm^–2电流密度的条件下,给药池药物浓度的增加(2.5,5.0,10.0 mg·mL^–1)可使累积透皮递送量显著增加。共离子导入对乙酰氨基酚证实了电迁移是CTS的主要递送机制(˃90%)。CTS的传导效率良好(6.63%~8.82%)。递送效率,即递送药物占所给予的制剂中的药物的百分数较高(在0.5 mA·cm^–2时>40%)。CTS从离子导入贮库HEC水凝胶中递送时的累积透皮递送量为(1 551.94±322.19)μg×cm^–2,与从CTS溶液中递送时的累积透皮递送量无统计学差异。结论 体外数据表明,使用较小面积的凝胶贴片通过透皮离子导入可以方便地递送治疗剂量的CTS。     

中西医结合治疗病毒性心肌炎62例

笔者近年来采用中西医结合的方法治疗急性病毒性心肌炎,取得良好效果,现报道如下.