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Objective
To compare the effects of cilostazol on cerebral arteries and cerebrovascular blood flow in secondary prevention of ischemic stroke, with those of aspirin.Methods
Sixty-eight patients who had ischemic stroke during the recent 1–6 months were recruited and randomized into cilostazol or aspirin group. Cerebrovascular condition was assessed by magnetic resonance angiography (MRA) and transcranial doppler ultrasonography (TCD) at the beginning of the study and after 12-month medication.Results
During the clinical follow-up, ischemic stroke recurred in 2 patients in cilostazol group, while in aspirin group, one case of ischemic stroke recurrence and one case of acute myocardial infarction were found. MRA revealed that in aspirin group, the percentages of patients experiencing aggravation and attenuation of cerebrovascular condition were 3.3% and 6.7%, respectively, while in aspirin group, they were 3.3% and 10%, respectively. Moreover, TCD revealed that 26.9% of the patients in aspirin group and 14.3% of the patients in cilostazol group experienced aggravation of cerebrovascular condition. However, the systolic peak flow velocity of the previously abnormal arteries increased by 42.9% after 12-month medication of cilostazol, which was significantly higher than that after aspirin medication (27.5%) (P = 0.04). Furthermore, as a major side effect of antiplatelet therapy, the frequrency of bleeding was much less in cilostazol group (0 case in cilostazol group vs 5 in aspirin, P < 0.05).Conclusion
Cilostazol is as effective as aspirin in preventing the aggravation of cerebral arteries in secondary prevention of ischemic stroke. Besides, it is more safe. Cilostazol can increase the systolic peak flow velocity of cerebral arteries, which may improve the blood supply of focal ischemia. 相似文献7.
曾国玲 《国际神经病学神经外科学杂志》1980,(5)
本文复习了有关婴儿和儿童非进行性共济失调性脑性瘫痪综合征的资料,描述了三个综合征:①单纯性共济失调(共济不能病征),②共济失调性双瘫(共济失调伴痉挛性双瘫)③平衡不良综合征(维持姿势和平衡困难).讨论了上述每个综合征的可能病因,对单纯性共济失调,胎儿期早期因素最重要,难以发现病因的病例比例高,遗传学因素起很大作用.遗传方式通常是染色体隐性遗传,其次是有先兆子痫的妊娠毒血症、脑出血、病毒感染、抗代谢药物、X线和营养 相似文献
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患者,叶某,女,已婚,34岁,工人。因"双膝关节疼痛伴双下肢乏力10~ 年,加重2~ 年"于1987年10月22日入院。患者10~ 年前无明显诱因开始出现右膝关节疼痛,行走后加重。3年后,累及左膝关节,但无红、肿,曾按"风湿性关节炎"治疗无效。病情缓慢进展,渐渐出现行路不稳,久坐后出现双下肢麻木感。行走虽困难,但昼夜无差异。近2年双膝关节疼痛加重,行走非常费力,勉强可行数百米远。发病后患者从未出现过视力障碍及二便障碍,患者既往体健,同胞一妹有轻度弓形足,"O"型腿。体检:内科检查正常。言语清晰。见双膝反张,轻度足内翻,弓形足。眼球各向运 相似文献
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本文通过四例传导性失语病人的康复研究认为:听觉言语短时记忆(A-STM)系统及言语信息,从A-STM到言语运动区的传递损害,是传导性失语的主要环节.视→说语言训练有助于语音的建立及消除听觉语言痕迹的相互抑制,促进传导性失语的康复。 相似文献
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