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Effect of Angelica sinensis polysaccharide-iron complex on iron deficiency anemia in rats 总被引:1,自引:0,他引:1
Objective:To investigate the therapeutic effects of Angelica sinensis polysaccharide- iron complex(APIC)on rats with iron deficiency anemia(IDA).Methods:The IDA rat model was established by adopting low-iron forage with a small amount of regular bloodletting.The rats were randomly divided into a model group,three AIPC groups(high,middle,and low dosage),an Angelica sinensis polysaccharide(ASP)group,a mixture group(ASP FeCl_3)and a positive control group (Niferex).Changes in hemoglobin(Hb),red blood cell count(RBC),hematocrit(HCT)and iron content of whole blood were observed.Results:There was a significant difference before and after administration in all treated groups and all indices were restored to near-normal levels in the APIC groups and the positive control group.There was a significant difference among the changes of the indices in all the APIC groups and those of the model group but not between those of the APIC groups and the positive control group.However,the recovery of the indices in the APIC groups was superior to that in the positive control group.Conclusion:APIC not only has a superior therapeutic effect on IDA,but also has the effect of the ASP on supplementing blood and activating blood circulation.Hence,it may be used as a new iron-supplementing agent with a double therapeutic efficacy on blood supplementation for the treatment of IDA. 相似文献
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正交试验优化当归多糖铁的合成条件研究 总被引:1,自引:0,他引:1
伞形科(Umblliferae)当归属植物当归[Angelica sinensis(Oliv.)Diels],是一味常用的传统中药,功能补血活血、调经止痛。研究表明,当归补血活血的作用主要是当归中的多糖成分刺激红细胞生成、促进造血祖细胞和多能造血干细胞的增殖和分化、从而提高造血水平的结果;换言之,当归多糖是当归补血活血的主要活性成分[1~7]。铁是构成机体内血红蛋白、肌红蛋白、细胞色素和多种氧化酶的重要成分,对于维持机体的正常生理作用不可或缺[8]。研究表明[9~11],多糖与高价铁配合生成的多糖铁复合物,用于缺铁性贫血的治疗,不仅具有较理想的稳定性、水溶性… 相似文献
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当归多糖铁复合物治疗缺铁性贫血大鼠的实验研究 总被引:2,自引:0,他引:2
目的:考察当归多糖铁复合物对缺铁性贫血大鼠的治疗效果,为当归多糖铁的开发与应用提供理论依据。方法:采用给予低铁饲料结合定期少量放血的方法建立缺铁性贫血大鼠模型,监测给药前后血红蛋白、红细胞计数、血细胞比容、全血铁等观察指标的变化。结果:各剂量当归多糖铁组(12.5,25,50 mg·kg~(-1))实验大鼠各项检测指标与阴性组比较均有显著差异(P<0.01)。各剂量当归多糖铁组实验大鼠各项检测指标与阳性组比较均无显著差异(P>0.05)。结论:当归多糖铁复合物具有较好的治疗缺铁性贫血作用,有望开发成为一种新型、具有双重补血作用的补铁剂。 相似文献
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当归多糖铁理化性质的初步研究 总被引:12,自引:1,他引:12
目的:对当归多糖铁的某些理化性质进行初步研究。方法:以高价铁盐的鉴别反应为依据,通过与氢氧化铁进行比较确定当归多糖铁的定性鉴别反应;置换碘量法测定当归多糖铁的铁含量;以氢氧化钠滴定当归多糖铁,根据当归多糖铁的水解情况,判断它在生理条件下的稳定性;采用邻菲罗啉比色法,对当归多糖铁进行还原性实验。结果:当归多糖铁显示高价铁盐的定性鉴别反应;铁含量介于10%~40%,水溶性与铁含量有关;水解性实验表明,当归多糖铁在pH 3~12性质稳定,无沉淀出现;还原性实验表明,在37℃的温度下,6 h内当归多糖铁中的Fe(Ⅲ)基本被还原剂抗坏血酸完全还原为Fe(Ⅱ)。结论:当归多糖铁可以采用高价铁的鉴别反应进行定性鉴别,铁含量在20%~25%有较好的水溶性,生理条件下理化性质稳定。 相似文献
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