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目的介绍按颅咽管瘤发生位置来分型方法,并探讨其临床价值。方法回顾性分析215例颅咽管瘤患者的临床资料,根据术前影像学资料、术中发现将颅咽管瘤划分为4种类型,即:Ⅰ型,鞍内颅咽管瘤;Ⅱ型,鞍上颅咽管瘤;Ⅲ型,室下颅咽管瘤;Ⅳ型,室前颅咽管瘤。结果59例Ⅰ型颅咽管瘤全部采用翼点入路切除肿瘤,全切除率为83.1%(49/59);75例Ⅱ型颅咽管瘤中,74例采用翼点入路,1例采用翼点联合胼胝体入路,全切率为82.7%(62/75);49例Ⅲ型颅咽管瘤,全部采用翼点入路,全切除率为93.9%(46/49);32例Ⅳ型颅咽管瘤,全部采用胼胝体入路,全切除率为93.8%(30/32)。结论按发生位置来分型颅咽管瘤是可行的,并使其各自成为相对独立的疾病,更有利于在制定诊疗方案和疗效评价上达成共识。 相似文献
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目的:研究血管生成在幕上星形细胞瘤中的意义。方法:采用免疫组化方法对71例幕上星形细胞瘤作von Willebrand因子染色,显示血管内皮细胞以检测肿瘤内微血管密度,分析微血管密度与肿瘤级别及患者预后的关系。结果:微血管密度与肿瘤级别密切相关(P>0.01),较高级别的肿瘤内微血管密度较高,Ⅳ级星形细胞瘤内微血管密度最高。预后分析显示微血管密度较高组的患者生存率较低(P<0.01)。结论:血管生成在肿瘤生长中发挥了重要作用,微血管密度是反映幕上星形细胞瘤患者预后的重要指标。 相似文献
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目的 探讨三磷酸腺苷结合盒转运体成员2(ABCG2)在人脑胶质瘤组织中的表达及其与胶质瘤分级和神经巢蛋白(nestin)表达的关系.方法 实时荧光定量聚合酶链反应(PCR)检测ABCG2在52例不同病理级别胶质瘤中的mRNA表达;免疫组织化学SABC法检测ABCG2和nestin的蛋白表达.结果 ABCG2在脑胶质瘤中的mRNA表达与正常脑组织比较呈过表达(P<0.05),且随着病理级别的升高而增加(P<0.05);免疫组织化学显示ABCG2在52例胶质瘤中的阳性表达率为32.7%(17/52),并与病理级别明显相关(x2=4.62,P<0.05),主要呈亲血管分布;ABCG2的表达与nestin的表达明显相关(x2=7.60,P<0.05).结论 ABCG2在人脑胶质瘤中的表达随着病理级别的升高而逐渐增加,且与nestin的表达呈正相关;脑肿瘤干细胞可能与神经干细胞具有一定的同源性. 相似文献
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婴幼儿脐疝非手术治疗方法改进 总被引:1,自引:0,他引:1
婴儿脐疝是由于腹腔壁肌肉和腱膜在脐部留下来的先天性发育缺陷,使腹膜等组织从脐环向外突出而形成疝。绝大多数没有闭锁的脐环在2岁时能自行闭锁,因此除了嵌顿或穿破等紧急情况外均可采取非手术疗法。现将改进的婴幼儿脐疝非手术治疗方法介绍如下。 相似文献
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人脑星形细胞瘤细胞凋亡及其相关基因bcl-2、Bax表达的研究 总被引:5,自引:0,他引:5
我们以常规福马林固定、石蜡包埋的人脑星形细胞瘤组织为材料 ,采用原位末端标记 (TUNEL)技术及免疫组织化学链酶卵白素 过氧化物酶 (SP)法对30例星形细胞瘤手术标本进行检测 ,分别观察肿瘤组织中凋亡细胞密度及bcl 2、Bax基因的表达状况。一、材料与方法1.材料 :取自我院 1997年 4月~1998年 3月间手术切除的人脑星形细胞瘤石蜡包埋标本 30例。其中男 18例 ,女 12例 ,年龄 2 8~ 5 7岁 ,术前未接受过任何放疗、化疗及免疫治疗。按WHO分类Ⅰ级 9例 ,Ⅱ级 12例 ,Ⅲ~Ⅳ级 9例。石蜡包埋组织作 4μm厚连续切片备用。抗bc… 相似文献
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目的:探讨荷瘤小鼠体内硒水平,谷胱甘肽过氧化物酶(GSH-Px)活力及丙二醛(MDA)含量的变化和亚硒酸钠对这种变化的影响。方法:采用DAN荧光法、DTNB比色法及TBA荧光法分别测定荷瘤及正常小鼠体内微量元素硒的含量、GSH-Px活力及过氧化脂质产物MDA的含量。结果:发现荷瘤小鼠体内全血及肝组织中硒的含量、肝匀浆中GSH-px活力均明显低于正常小鼠。亚硒酸钠虽然在该实验剂量下对S-180肉瘤的生长没有显著的抑制作用,但能纠正荷瘤小鼠全血及肝组织中硒含量的下降,增加全血及肝组织中GSH-Px活力,降低血浆中MDA的含量,对抗CCl4引起的肝组织中GSH-px活力下降。结论:亚硒酸钠能对抗肿瘤对机体抗氧化能力的削弱作用,这时肿瘤的预防和治疗有一定意义。 相似文献
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Objective To study the expression of ATP-binding cassette superfamily G member 2 ( ABCG2) and its relationship with the malignant degree and expression of nestin in human gliomas. Methods Fifty-two gliomas of different WHO grades and 8 normal brain tissues were detected for the mRNA expression of ABCG2 by using real-time quantitive polymerase chain reaction (PCR). And the protein expression of ABCG2 and nestin was detected by immunohistochemistry. Results The mRNA of ABCG2 was overexpressed in gliomas as compared with that in normal brain tissues (P<0. 05), and up-regulated with the increase of pathologic degrees (P<0. 05 ). The positive protein expression rate of ABCG2 in 52 gliomas was 32.7%. The positive rate was significantly higher in grade Ⅲ-Ⅳ than in grade Ⅰ -Ⅱ (x2 =4. 62, P < 0. 05). And the expression level of ABCG2 was obviously related with the expression of nestin (x2= 7. 60,P < 0.05). Conclusion The expression level of ABCG2 was obviously related with glioma pathological grade and the expression of nestin. Brain tumor stem cells may have some homology with nerve stem cells. 相似文献
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Objective To study the expression of ATP-binding cassette superfamily G member 2 ( ABCG2) and its relationship with the malignant degree and expression of nestin in human gliomas. Methods Fifty-two gliomas of different WHO grades and 8 normal brain tissues were detected for the mRNA expression of ABCG2 by using real-time quantitive polymerase chain reaction (PCR). And the protein expression of ABCG2 and nestin was detected by immunohistochemistry. Results The mRNA of ABCG2 was overexpressed in gliomas as compared with that in normal brain tissues (P<0. 05), and up-regulated with the increase of pathologic degrees (P<0. 05 ). The positive protein expression rate of ABCG2 in 52 gliomas was 32.7%. The positive rate was significantly higher in grade Ⅲ-Ⅳ than in grade Ⅰ -Ⅱ (x2 =4. 62, P < 0. 05). And the expression level of ABCG2 was obviously related with the expression of nestin (x2= 7. 60,P < 0.05). Conclusion The expression level of ABCG2 was obviously related with glioma pathological grade and the expression of nestin. Brain tumor stem cells may have some homology with nerve stem cells. 相似文献