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国内外学者对人参皂甙抗肿瘤作用做了大量工作,并肯定了其效果。但人参价格昂贵,资源有限,开发人参并寻找人参代用药进一步综合利用,具有一定经济价值和实际意义。近年来,吉林大学从吉林产人参地上部分提纯出新的挥发成分(GVO_2),是否具有抗癌作用,目前国内外尚未见报道。我室近两年用GVO_2对体外培养的人胃癌细胞SGC-803和小鼠腹水肝癌细胞进行了抗癌研究,现将结果报告如下。 (一) 实验方法 1.GVO_2对体外培养胃癌细胞SGC- 相似文献
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西洋参多糖PPQI-1~4理化性质的研究 总被引:1,自引:0,他引:1
AIM: To study the characteristics of the four bioactive pure polysaccharides of Panax quiquefolium L. (PPQI 1~4). METHODS: The polysaccharides were extracted with hot water and grade precipitated with ethanol. They were further purified with Sephadex DEAE A50 and Sephadex G200 chromatography. The molecular weights of the polysaccharides were determined with matrix assisted laser desorption/ionization mass spectrometry (MALDI MS). The sugar compositions were analyzed with GC. The linkage positions of the component sugars were determined by methylation and GC MS. RESULTS: The four polysaccharides are all uronic acid containing heteropolysaccharides with the component sugars of arabinose, galactose and glucose in different molar ratios. The uronic acid contents are within 30%~60%. Their molecular weights are in the range of 2×104~7×104u. CONCLUSION: The four new bioactive polysaccharides are all uronic acid containing heteropolysaccharides. 相似文献
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西洋参多糖PPQI-1~4理化性质的研究 总被引:2,自引:0,他引:2
西洋参(PanaxquinquefoliumL.)系五加科人参属多年生草本植物,药用历史悠久。作者用多糖皂甙联合提取法[1],从西洋参根中提取出西洋参多糖(PPQ)。小鼠体内活性实验结果显示,西洋参根粗多糖有较好的抑制S180肉瘤生长活性;对抗癌化疗药环磷酰胺所致小鼠免疫功能低下有拮抗作用[2]。以体外细胞因子刺激活性为指标进行活性跟踪实验,通过乙醇分级分离、Sephadex凝胶过滤多次分离,得到4个西洋参活性多糖(PPQI1~4)。它们有较好的刺激小鼠脾淋巴细胞转化、诱导白介素2(IL2… 相似文献
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