Roles and mechanisms of ginseng in protecting heart

Ginseng,the root of Panax ginseng C.A.Mayer,has long been used clinically in China to treat various diseases.Multiple effects of ginseng,such as antitumor,antiinflammatory,antiallergic,antioxidative, antidiabetic and antihypertensive have been confirmed by modern medicine.Recently,the clinical utilization of ginseng to treat heart diseases has increased dramatically.The roles of ginseng in protecting heart are foci for research in modern medical science and have been partially demonstrated,and the mechanisms of protection against coronary artery disease,cardiac hypertrophy,heart failure,cardiac energy metabolism,cardiac contractility,and arrhythmia are being uncovered progressively.However,more studies are needed to elucidate the complex mechanisms by which ginseng protects heart.All such studies will provide evidence of ginseng’s clinical application,international promotion,and new drug development.     

甘草次酸对大鼠心室肌细胞钠离子通道电流的影响

目的 研究甘草次酸对大鼠心室肌细胞钠离子通道电流(INa)的影响,探讨甘草次酸在离子通道水平抗心律失常的作用机制。方法 急性分离雄性SD大鼠心室肌细胞,通过膜片钳全细胞记录技术观察甘草次酸对大鼠心室肌细胞INa的影响。结果 甘草次酸可剂量依赖地抑制大鼠心室肌细胞钠电流。1、5、10 μmol/L甘草次酸使大鼠心室肌细胞钠电流自［(-4.26±0.15)nA］,分别降低至［(-3.54±0.1)nA］,［(-2.19±0.09)nA］,［(-1.25±0.08)nA］,差异均有统计学意义。1、5、10 μmol/L甘草次酸对大鼠心室肌细胞钠电流峰值的抑制率分别为(16.08±2.3)%、(50.82±3.56)%、(75.98±5.12)%。10 μmol/L甘草次酸使INa电流-电压关系曲线上移,但不改变其激活电位和峰电位。结论 甘草次酸可浓度依赖地抑制大鼠心室肌细胞INa,其抗心律失常作用可能与此相关。     

参附汤对慢性心力衰竭大鼠血流动力学的影响

目的:观察参附汤对慢性心力衰竭大鼠的血流动力学的影响.方法:通过结扎大鼠左冠状动脉前降支的方法建立心力衰竭模型,在术后1周给予参附汤,连续给药4周,并检测其血流动力学指标.结果:参附汤能显著改善心衰大鼠的血流动力学各项指标,增加LVSP、±dp/dtmax,降低LVEDP.结论:参附汤能通过改善心肌梗死后心力衰竭大鼠血流动力学指标,从而有效改善心功能.