燕山蛩提取物对瘤细胞作用的观察

我们观察到,燕山蛩(Spirobolus bungii Brandt.)提取物对小鼠某些实体型和腹水型移植性肿瘤生长有一定抑制作用,特别对腹水型肿瘤,用对实体瘤有效剂量的1/4～1/6,甚则1次腹腔给药,就有显著抑制癌细胞增殖和延长动物存活时间的作用,提示燕山蛩提取物对癌细胞可能具有直接损伤作用。为此,我们用组织学和扫描电镜方法,观察了它对癌细胞的作用。     

EFFECT OF EXTRACTS OF SPIROBOLUS BUNGII ON TRANSPLANTED TUMORS IN MICE

The anti-tumor effect of “Yanshanqiong”燕山蛩 (Spirobolus bungii Brandt) extracts wasstudied in mice with solid uterocervical carcino-ma (U_(14)),sarcoma-37,Lewis lung carcinoma andascites uterocervial carcinoma,sarcoma-180,Ehrlich tumor.The agents tested includedwater,ethanol,ether and ethanol-ether extracts.All extracts were intraperitoneally administeredin solid-tumor-bearing mice for 12-14 days andascites-tumor-bearing mice for 4-8 days.Theoptimal daily dose established for these 4 ex-tracts was 0.3,1.3,0.15-0.30 and 0.05-0.20g/kg bodyweight respectively.The tumor-growth-inhibit-ing effect was determined for these extracts inanimals with U_(14),Lewis and U_(14)A,S_(180)A,ECAand ranged from 28.2 to 59.8% in solid tumor     

OBSERVATION OF THE EFFECT OF SPIROBOLUS BUNGII EXTRACT ON CANCER CELLS

Mice with ascites type (U_(14)A) carcinomawere treated (i.p.200 mg/kg once only) withextract of Spirobolus bungii Brandt.An increasein cancer cell death ratio of 35% was seen 2hours after treatment.The injured cells pre-sented karyopyknosis,karyoclasis,cytoclasis andvacuolization.Tumor mitosis was immediatelyarrested.Even 24 hours after exposure the ratioof mitosis was below the starting level.Scan-ning electron microscopy also revealed signifi-cant changes:the cancer cell plasma membraneappeared crenate in the form of villus-like pro-jections and the surface of the membrane be-     

彩色多普勒超声对塞外贫困山区特异性心肌病特点的评价

目的　应用彩色多普勒超声心动图评价塞外贫困山区特异性心肌病的特点。方法　 2 80例可疑心肌病患者接受彩色多普勒超声心动图检查。结果　检出特异性心肌病 90例 ,其中 ,酒精性心肌病 3 5例占 3 9%。结论　彩色多普勒超声心动图检查经济、方便 ,并可通过疗效观察与评价 ,进一步明确特异性心肌病的诊断     

六味地黄汤防治肿瘤的实验研究

祖国医学认为,肿瘤是由正气先虚,留滞客邪,气滞血瘀,邪毒积聚成块所形成。《素问》指出:正气存内,邪不可干。《医宗必读·积聚篇》说:积之成者,正气不足,而后邪气踞之。恶性肿瘤形成以后,肿瘤能否在体内发展、扩散,决定于邪正相搏,孰胜孰负。邪气盛则实,正气夺则虚。肿瘤患者后期常呈阴、阳、气、血偏虚的见证,故祖国医学对体内肿块的处理,除了攻、削、散、除诸法以外,还重视用补法治疗。金元以来,即有“养正积除”之说。近年来,一些单位在临床实践中证实,扶正法治疗肿瘤确有一定效果。说明扶正祛邪治则在中西医结合治疗肿瘤中是值得进一步探讨的一个途径。六味地黄汤(丸),系宋代钱乙制订的滋肝补肾方剂。全方六味,三补三泻,开阖兼顾,寒燥不偏。虽功专肾肝,而六经备治。宜于肾水不足、虚火上炎所致的诸证,是滋阴特别是滋肾阴的通用方,向为历代医     

燕山蛩提取物对小鼠移植性肿瘤的影响

河南省南阳地区民间流传用燕山蛩治疗食管癌。《本草纲目》记载它“有大毒”,可“烧黑,傅恶疮”。我们在采风的基础上对它进行了动物实验,在实验中发现,它的提取物对小鼠某些移植性肿瘤生长有一定抑制作用,且毒性不大。现将结果报道如下。     

EFFECT OF“LIUWEI DIHUANG DECOCTION六味地黄汤” ON PREVENTIONANDTREATMENTOFTUMOR

Clinical and experimental investigations ofLiuwei Dihuang decoction(LWDH,an ancientrecipe)were made in our laboratory.LWDHdecreased the incidence of tumor of anteriorstomach or lung produced by N-nitrososarcosineor urethan in mice,prolonged the life of tumor-bearing animals,and increased the cAMP con-tent in murine uterocervical carcinoma(U_)cells.The recipe enhanced the phagocytic func-tion of the reticuloendothelial system,promot-ed the proliferation of hemogenic stem cells andlymphoid tissue,maintained thyroid function,and decreased the catabolism of protein in U_-bearing mice.LWDH also strengthened the mus-cles and increased body weight in normal mice.Patients with epithelial dysplasia of esopha-gus,a preneoplastic lesion of esophageal car-cinoma,were treated by using this recipe.Thecanceration rate within 1 year was 2.2%(2/92)in the treated,and 12.4%(11/89)in an untreatedgroup.Within 5 years these rates were 9%(5/57)and 26%(12/47)respectively(P<0.025).