男性乳头基底细胞癌1例

患者男,64岁,右侧乳头破溃,反复渗出流血3年余。皮肤科情况：右侧乳头呈灰蓝色,中央溃疡凹陷,表面少量渗出、流血,部分上覆棕色结痂。左侧乳头及乳晕正常。双侧腋窝未触及肿大的淋巴结。皮损组织病理示：真皮内可见嗜碱性基底样细胞构成的大小不等的肿瘤细胞团块,团块周边排列成栅栏状,可见收缩间隙。诊断：结节/溃疡型基底细胞癌。治疗：行手术治疗,患者术后恢复较好,目前仍在随访中。     

成人Spitz痣1例

患者男,20岁.因鼻粱左侧结节半年余,于2008年11月24日就诊.患者于半年前发现鼻梁左侧有一棕红色丘疹.渐增大,无痛痒,未经过任何治疗.既往体健,家族成员中无类似疾病患者.     

Association of rs10954213 polymorphisms and haplotype diversity in interferon regulatory factor 5 with systemic lupus erythematosus: A meta-analysis

The rs10954213 polymorphism and the haplotype diversity in interferon regulatory factor 5 (IRF5) play a special role in systemic lupus erythematosus (SLE) but with inconclusive results. We conducted a meta-analysis integrating case-control and haplotype variant studies in multiple ethnic populations to clearly discern the effect of these two variants on SLE. Eleven studies on the relation between rs10954213 polymorpisms in IRF5 and SLE were included and we selected a random effect model to calculate the pooled odds ratios (ORs) and the corresponding 95% confidence interval (95% CI). A total of 6982 cases and 8077 controls were involved in the meta-analysis. The pooled results indicated that A allele was significantly associated with increased risk of SLE as compared with the IRF5 rs10954213 G allele (A vs. G, P<0.00001) in all subjects. The same pattern of the results was also obtained in the European, African American, and Latin American. Asian population had a much lower prevalence of the A allele (49.1%) than any other population studied, and Europeans had the highest frequency of the IRF5 rs10954213 A allele (62.1%). The significant association of increased SLE risk and TCA haplotype was indicated in the contrast of TCA vs. TTA as the pooled OR was 2.14 (P=0.002). The same result was also found in the contrast of TCA vs. TTG as the pooled OR was 1.45 (P=0.004). This meta-analysis suggests that the A allele of rs10954213 and TCA haplotype (rs2004640-rs2070197-rs10954213) in IRF5 is associated with the increased risk of SLE in different ethnic groups, and its prevalence is ethnicity dependent.     

同一患者两处脂溢性角化病皮损伴Meyerson现象一例

患者男,65岁,因左上背、左小腿褐色丘疹20余年,周边起红斑、丘疹、渗出伴瘙痒2月余,于2010年11月25日来我院皮肤科就诊.20多年前左小腿发生1个、左上背发生多个褐色丘疹,无显著不适.2个月前左上背其中1个及左小腿褐色丘疹周边发生红斑、丘疹伴瘙痒,搔抓后有渗出,后因皮损周边红斑扩大,渗出和瘙痒加重就诊.皮肤科检查:左侧小腿及左上背部各有一直径约0.5 cm大小的褐色丘疹,边缘规则,无溃疡、渗血.丘疹周围1～ 1.5 cm范围内分布红斑、丘疹、鳞屑,伴有轻度渗出,边界较清.环形红斑与中央褐色丘疹之间炎症较轻,伴轻度色素减退(图1,2).     

浅谈皮肤科来华留学研究生培养的心得体会及建议

来华留学生培养是中国高等教育的重要组成部分,是提高中国高等教育的国际知名度、中国大学国际化程度的环节之一.皮肤科留学研究生的培养在来华留学生中有一定的需求,但大多数以东南亚来源国和非洲国家为主,其文化背景、医学基础知识差异大,很多不懂中文,缺乏统一的英文或英汉皮肤性病学教材等,这些都给带教老师带来了较大的挑战.该文分享...     

多发痛风结节1例

临床资料 患者男,55岁.因"双手指、足第一趾跖关节内侧发生黄色结节20年余"就诊.轻压痛,皮疹可自行破溃,溢出豆渣样物,伴全身关节反复疼痛.皮肤科查体:双手指、足第一跖趾关节内侧黄白色或淡黄色结节,绿豆至核桃大,质中到硬,关节活动略受限.     

葡萄球菌性烫伤样皮肤综合征32例临床分析

葡萄球菌性烫伤样皮肤综合征(staphylococcal scalded skin sydrome,SSSS)是由金黄色葡萄球菌产生的表皮剥脱毒素(exfoliative toxin,ET)引起的,好发于婴幼儿的急性皮肤感染性疾病.本病以往相对少见,但随着金黄色葡萄球菌感染率日益增加,对常规抗生素的耐药性也增加,此病的发病率有增高的趋势,即使使用了广谱抗生素,此病也有着较高的死亡率.1因此,提高对该病的认识很有必要.我们对近4年来诊断的32例SSSS患儿进行了总结和分析报道如下.     

右足背巨大增生性外毛根鞘瘤1例

临床资料 患者男,57岁,农民.因"右足背热油烫伤后40余年,赘生物伴溃疡5年,加重4个月"入院.患者10岁时右足背、踝前被热油烫伤,愈后形成增生性疤痕,足背挛缩.夏季光脚在田间劳动后疤痕皲裂,一直未愈.5年前夏季,患者右足背疤痕皲裂后,冬季未愈合,渐向周围缓慢增生扩展,形成不规则溃疡,有时表面有分泌物,伴有恶臭,在当地给予草药外敷无效,4个月前渐扩展至整个足背及小腿下端原疤痕部位.     

缺氧诱导因子-1α和环氧合酶-2在尖锐湿疣中的表达

目的：检测缺氧诱导因子-1α（HIF-1α）和环氧合酶-2（COX-2）在尖锐湿疣组织中的表达。方法：采用免疫组化SP法检测30例尖锐湿疣组织和20例包皮组织中HIF—1α和COX-2的表达。结果：尖锐湿疣组织中HIF-1α和COX-2的阳性表达率及阳性表达强度均显著高于正常对照组（均P〈0．01），尖锐湿疣组织中HIF—1α与COX-2的表达呈正相关。结论：尖锐湿疣组织的过度增殖可能与组织中HIF—1α和COX-2的异常表达有关。