Choleretic activity of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol on the model of CCl<Subscript>4</Subscript>-induced hepatitis

Therapeutic administration of 11-deoxymisoprostol had a hepatoprotective effect, which manifested in a decrease in the content of alanine transaminase and aspartate transaminase in blood plasma, and produced a choleretic effect in rats with CCl₄-induced toxic hepatitis. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 183–184, February, 2008     

Modification of N 1-(2,6-dimethylphenyl)-N 2,N 2-diethylglycinamide and 4-amino-N[2-(diethylamino)ethyl]benzamide in order to increase their antiarrhythmic effect

A structure–antiarrhythmic activity relationship has been investigated using a chloroform model of arrhythmia in rats. A mathematical model capable of predicting and recognizing antiarrhythmic activity with 84% reliability is formulated. Optimization of the molecular design of lidocaine and procainamide, which have weak antiarrhythmic activity, has resulted in modeling and predicting 51 much more effective antiarrhythmic compounds that can be synthesized for further testing.     

Physicochemical Properties and Pharmacological Activity of Mn(II), Fe(II), Co(II), Cu(II), AND Zn(II) Gluconates

Pharmaceutical Chemistry Journal -     

Synthesis of Betulinic Acid from Betulin Extract and Study of the Antiviral and Antiulcer Activity of Some Related Terpenoids

Pharmaceutical Chemistry Journal -     

Synthesis and biological activity of 3-N-substitued 2,5-dichloro-4,4-dimethoxy-5-allylcyclopent-2-ene-1-ones

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, No. 4, pp. 55–57, April, 1992.