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Christopher Yeh Cem Atillasoy John T. Seykora Vivian Lee 《Journal of cutaneous pathology》2021,48(1):171-173
Respiratory cysts are benign lesions lined by normal respiratory epithelium. There are few reported cases localized to the orbit, while those of the eyelid are exceedingly rare. Respiratory cysts usually arise either from a non‐hereditary congenital malformation, where they are distinguished as choristomatous, or from trauma. Here, we report a case of a 53‐year‐old man who presented with a large right lower eyelid cyst that was histopathologically diagnosed as a respiratory cyst. 相似文献
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Acid-suppressive drugs, including histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), are common medications used for treating upper gastrointestinal tract disorders. However, acid-suppressive drugs have been reported to increase the risk of pneumonia in numerous disease populations. However, the relationship between acid-suppressive drugs and stroke-associated pneumonia (SAP) remains controversial.The purpose of this study was to investigate the association between acid-suppressive drug usage and pneumonia among patients with stroke by using a nationwide data set.A population-based cohort study was conducted using a data set from the Taiwanese National Health Insurance Research Database. Data on patients with new-onset stroke from 2010 to 2011 were collected. Patients with and without acid-suppressive drug usage were followed up to identify the occurrence of any type of pneumonia. We estimated the adjusted hazard ratios (HRs) by using the Cox proportional hazards model.The study cohort comprised 7965 patients with new-onset stroke. The incidence of pneumonia was 6.9% (552/7965) and more than 40% (225/552) of patients developed pneumonia within 3 months after an acute stroke. Acid-suppressive drug usage was an independent risk factor of pneumonia. The adjusted HR for the risk of pneumonia in patients with new-onset stroke using acid-suppressive drugs was 1.44 (95% confidence interval [CI] = 1.18–1.75, P < 0.01). Only PPI usage increased risk of chronic SAP (adjusted HR = 1.46, 95% CI = 1.04–2.05).Acid-suppressive drug usage was associated with a slightly increased risk of SAP. Physicians should exercise caution when prescribing acid-suppressive drugs to patients with stroke, particularly at the chronic stage. 相似文献
5.
Therapy of human cervical carcinoma with monoclonal antibody-Pseudomonas exotoxin conjugates. 总被引:1,自引:0,他引:1
Pseudomonas exotoxin A (PE) linked to the F(ab')2 fragment of 1H10, a murine monoclonal antibody recognizing a carbohydrate epitope of a glycoconjugate expressed on the surface of human cervical carcinoma tumor cells, was evaluated for in vitro and in vivo activity. PE can kill cells by ADP-ribosylating elongation factor 2 thus inhibiting protein synthesis. Disulfide- as well as thioether-linked immunotoxins (1H10-PE) killed cervical carcinoma cells in vitro and were 20-160 times more inhibitory to target than to control cells. Cell killing was antibody mediated as demonstrated by the reduction of 1H10-PE growth inhibition to target CaSki cells by free 1H10 F(ab')2. In addition, a control antibody immunotoxin was nontoxic to CaSki cells. Thioether-linked 1H10-PE administered either i.v. or i.p. suppressed the growth of established solid s.c. cervical carcinoma tumors xenografted in nude mice for over 30 days. Treatment with antibody alone or a control immunotoxin had no significant effect on tumor growth. Administration of immunotoxin i.p. was associated with less toxicity than administration i.v., but i.v. injections were more effective at suppressing the growth of established solid tumors. 相似文献
6.
Fu-Wei Wang Yu-Wen Chiu Ming-Shium Tu Ming-Yueh Chou Chao-Ling Wang Hung-Yi Chuang 《International archives of occupational and environmental health》2009,82(7):819-825
Purpose There has been increasing interest in the occupational health of workers in small enterprises, especially in developing countries.
This study examines the association between psychosocial job characteristics and fatigue, and attempts to identify risk factors
for fatigue among workers of small enterprises in southern Taiwan.
Methods A structured questionnaire was administered to workers receiving regular health examinations between August 2005 and January
2006. The questionnaire collected demographic information and data on working conditions, personal health status and life
styles. It also collected information on psychosocial job characteristics, fatigue and psychological distress using three
instruments.
Results A total of 647 workers with mean age of 43.7 were completed. Probable fatigue was found in 34.6% of the sample. Fatigue was
found by multiple logistic regressions to be associated with the lack of exercise, working in shifts, depression score and
lack of social support at workplace.
Conclusions This study found associations between life style, psychosocial job characteristics and fatigue. Because the high prevalence
of probable fatigue was found in such small enterprises, the authors suggest that a short interview with some quick questionnaires
in health checkup for these small enterprise workers are helpful to early detect psychosocial and fatigue problems. 相似文献
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An investigation of the influence of the short-chain branch length on the dynamic fatigue behavior of short-chain branched polyethylenes (SBPE) is reported. The number of fatigue failure cycles (Nf) increases significantly with increasing branch length at temperatures above the β-transition of SBPE polymers. In addition, an examination of the fracture surfaces of these specimens indicates a transition to a more ductile-type behavior when specimens are associated with larger branch lengths. Detailed characterization shows that these SBPEs have approximately the same molecular weight, molecular weight distribution, branch frequency, crystallinity or microstructure but different branch length. The difference in branch length is suggested to be responsible of the dramatic change in Nf and in the morphology of the fracture surface at temperatures above the β-transition of SBPEs. In contrast, no significant change in Nf and in the morphology of the fracture surface were found with increasing branch length at temperatures near or below the β-transition. This dramatic change in the effect of short-chain branches on Nf and on the morphology of the fracture surface are attributed to the change in the molecular relaxation motion at temperatures near the β-transition of SBPE polymers. 相似文献
9.
Y M Chung T S Yeh Y Y Tsai H Chiang J H Liu 《Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde》1988,196(3):161-166
Lymphomatoid granulomatosis is an angiocentric and angiodestructive lympho-proliferative disorder involving multisystems but rarely conjunctiva. We present a 62-year-old Chinese female with lymphomatoid granulomatosis who had an ulcerative conjunctival nodule. Conjunctival biopsy revealed pathological findings important for diagnosis and indicating progression of disease severity. To our knowledge, this is the first report to demonstrate pathological findings characteristic of lymphomatoid granulomatosis with conjunctival involvement. 相似文献
10.
Huey-Juan Lin Poh-Shiow Yeh Tsung-Chia Tsai Tain-Junn Cheng Dershin Ke Kao-Chang Lin Jih-Gong Ho Chia-Yu Chang 《Journal of clinical neuroscience》2007,14(1):17-21
Using a prospective hospital-based registry, 146 patients with transient ischaemic attack (TIA) were compared with 376 patients with minor first-ever ischaemic stroke with respect to the 3-month risk of subsequent vascular events, in order to clarify the distinctions between the disease entities. All patients were enrolled within 48 h of onset. The risk factor distribution for the two groups was comparable, except that the TIA patients had more previous TIAs. Large artery atherosclerosis (34%) and small vessel occlusion (32%) were the main aetiologies in the TIA group, whereas small vessel occlusion (49%) was the major cause in the stroke group. The 3-month risk of combined endpoints of stroke, myocardial infarction, and vascular death for TIA patients was higher than that for the minor stroke group (15.1% vs. 3.2%; hazard ratio 4.6, 95% confidence interval 2.3-9.3 in multivariate analysis). Large artery atherosclerosis and male sex were the other significant predictors. TIA may demand more urgent management than minor stroke. The fact that aetiology is a predictor, highlights the need for rapid diagnostic tests to establish pathogenesis. 相似文献