Experimental study on regulation of blood glucose by 1400w （N-3-aminomethyl-benzyl-acetamidine）

AIM: To study the prevention and cure of N-3-aminomethyl-benzyl-acetamidine (1400w), a high selective iNOS inhibitor, on hyperglycemic mellitus induced by STZ, which inhibits NOS activity 100 times stronger than equal dose of AG in rat. METHODS: Hyperglycemic mice model was established by 130 mg/kg STZ. Blood glucose and serum NO concentration was     

Chiral pharmacokinetics and inversion of N^G-nitro-arginine in the rat

AIM: To explore pharmacokinetics of N^G-nitro-D-arginine (D-NNA) and N^G-nitro-L-arginine (L-NNA) in conscious rats.METHODS: The plasma concentration of D-NNA and L-NNA were determined by chiral ligand exchange method with capillary electrochromatography (CEC). Pharmacokinetic parameters were estimated using non-compartment model and were fitted using a computer program DAS. Chiral inversion rate of D-NNA to L-