全文获取类型
收费全文 | 35585篇 |
免费 | 2251篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 360篇 |
儿科学 | 880篇 |
妇产科学 | 663篇 |
基础医学 | 4846篇 |
口腔科学 | 896篇 |
临床医学 | 3346篇 |
内科学 | 6879篇 |
皮肤病学 | 568篇 |
神经病学 | 3865篇 |
特种医学 | 1534篇 |
外国民族医学 | 56篇 |
外科学 | 4877篇 |
综合类 | 466篇 |
一般理论 | 12篇 |
预防医学 | 2952篇 |
眼科学 | 910篇 |
药学 | 2417篇 |
中国医学 | 35篇 |
肿瘤学 | 2358篇 |
出版年
2022年 | 237篇 |
2021年 | 466篇 |
2020年 | 290篇 |
2019年 | 488篇 |
2018年 | 567篇 |
2017年 | 451篇 |
2016年 | 510篇 |
2015年 | 669篇 |
2014年 | 860篇 |
2013年 | 1339篇 |
2012年 | 1959篇 |
2011年 | 2029篇 |
2010年 | 1131篇 |
2009年 | 1063篇 |
2008年 | 1896篇 |
2007年 | 2001篇 |
2006年 | 1939篇 |
2005年 | 1964篇 |
2004年 | 1822篇 |
2003年 | 1710篇 |
2002年 | 1666篇 |
2001年 | 674篇 |
2000年 | 620篇 |
1999年 | 546篇 |
1998年 | 378篇 |
1997年 | 365篇 |
1996年 | 319篇 |
1995年 | 289篇 |
1994年 | 273篇 |
1993年 | 269篇 |
1992年 | 366篇 |
1991年 | 356篇 |
1990年 | 347篇 |
1989年 | 341篇 |
1988年 | 312篇 |
1987年 | 335篇 |
1986年 | 297篇 |
1985年 | 341篇 |
1984年 | 328篇 |
1983年 | 294篇 |
1982年 | 283篇 |
1981年 | 275篇 |
1980年 | 252篇 |
1979年 | 271篇 |
1978年 | 223篇 |
1977年 | 162篇 |
1976年 | 192篇 |
1975年 | 182篇 |
1974年 | 211篇 |
1973年 | 169篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Edward J. Holland Walter O. Whitley Kenneth Sall Stephen S. Lane Aparna Raychaudhuri Steven Y. Zhang 《Current medical research and opinion》2016,32(10):1759-1765
Objective: Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED).Research design and methods: Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were randomized (1:1) to lifitegrast 5.0% or matching placebo. Changes from baseline to day 84 in signs and symptoms of DED were analyzed.Main outcome measures: Phase 2, pre-specified endpoint: inferior corneal staining score (ICSS; 0–4); OPUS-1, coprimary endpoints: ICSS and visual-related function subscale (0–4 scale); OPUS-2, coprimary endpoints: ICSS and eye dryness score (EDS, VAS; 0–100).Results: Fifty-eight participants were randomized to lifitegrast 5.0% and 58 to placebo in the phase 2 trial; 293 to lifitegrast and 295 to placebo in OPUS-1; 358 to lifitegrast and 360 to placebo in OPUS-2. In participants with mild-to-moderate baseline DED symptomatology, lifitegrast improved ICSS versus placebo in the phase 2 study (treatment effect, 0.35; 95% CI, 0.05–0.65; p?=?0.0209) and OPUS-1 (effect, 0.24; 95% CI, 0.10–0.38; p?=?0.0007). Among more symptomatic participants (baseline EDS ≥40, recent artificial tear use), lifitegrast improved EDS versus placebo in a post hoc analysis of OPUS-1 (effect, 13.34; 95% CI, 2.35–24.33; nominal p?=?0.0178) and in OPUS-2 (effect, 12.61; 95% CI, 8.51–16.70; p?<?0.0001).Limitations: Trials were conducted over 12 weeks; efficacy beyond this period was not assessed.Conclusions: Across three trials, lifitegrast improved ICSS in participants with mild-to-moderate baseline symptomatology in two studies, and EDS in participants with moderate-to-severe baseline symptomatology in two studies. Based on the overall findings from these trials, lifitegrast shows promise as a new treatment option for signs and symptoms of DED. 相似文献
2.
Arjenne H.M. Gussenhoven Amika S. Singh S. Theo Goverts Marten van Til Johannes R. Anema Sophia E. Kramer 《International journal of audiology》2015,54(8):507-517
Objective: A multidisciplinary vocational rehabilitation programme, the Vocational Enablement Protocol (VEP) was developed to address the specific needs of employees with hearing difficulties. In the current study we evaluated the process of implementing the VEP in audiologic care among employees with hearing impairment. Design: In conjunction with a randomized controlled trial, we collected and analysed data on seven process parameters: recruitment, reach, fidelity, dose delivered, dose received and implemented, satisfaction, and perceived benefit. Study sample: Sixty-six employees with hearing impairment participated in the VEP. The multidisciplinary team providing the VEP comprised six professionals. Results: The professionals performed the VEP according to the protocol. Of the recommendations delivered by the professionals, 31% were perceived as implemented by the employees. Compliance rate was highest for hearing-aid uptake (51%). Both employees and professionals were highly satisfied with the VEP. Participants rated good perceived benefit from it. Conclusions: Our results indicate that the VEP could be a useful treatment for employees with hearing difficulties from a process evaluation perspective. Implementation research in the audiological setting should be encouraged in order to further provide insight into parameters facilitating or hindering successful implementation of an intervention and to improve its quality and efficacy. 相似文献
3.
Michelle Cleary Garry Walter Jan Sayers Violeta Lopez Catherine Hungerford 《Issues in mental health nursing》2015,36(4):266-271
Cultures of performativity may contribute to organizational and individual arrogance. Workplace organizations have individuals who at various times will display arrogance, which may manifest in behaviours, such as an exaggerated sense of self-importance, dismissiveness of others, condescending behaviors and an impatient manner. Arrogance is not a flattering label and irrespective of the reason or the position of power, in the context of organizational behaviors, may not be useful and may even be detrimental to the work environment. Thus, it is timely to reflect on the implications of arrogance in the workplace. Advocacy and empowerment can be undermined and relationships adversely impacted, including the achievement of positive consumer outcomes. This paper provides an introduction to arrogance, and then discusses arrogance to promote awareness of the potential consequences of arrogance and its constituent behaviors. 相似文献
4.
5.
6.
Agenesis of the Gallbladder Revisited Laparoscopically 总被引:1,自引:0,他引:1
Najam Azmat M.D. Kenneth R. Francis M.D. Neal Mandava M.D. Walter F. Pizzi M.D. 《The American journal of gastroenterology》1993,88(8):1269-1270
Gallbladder agenesis is an extremely rare disease. Necropsy incidence has been reported to be 0.016%. Failure lo locate the gallbladder at the time of a planned cholecystectomy can be very challenging. We report such a case during a laparoscopic cholecystectomy. The indication for surgery in these patients are complaints of gallbladder symptoms along with a false-positive ultrasound study. During exploration, an abnormal location of the gallbladder has to be excluded. Ectopic gallbladder locations include intrahepatic, lesser omentum, retroperitoneal, retrohepatic, within the falciform ligament, retroduodenal, and retrohepatic areas. Thorough exploration and cholangiography are essential. Embryologically, the gallbladder and cystic duct arise from the caudal portion of the hepatic bud. All of the previously reported cases of gallbladder agenesis have shown an absence of both the gallbladder and cystic duct. We report an embryological oddity wherein a patent cystic duct was found along with an agenetic gallbladder. This is the first case report of this finding, along with this being the first absent gallbladder discovered laparoscopically. 相似文献
7.
8.
Peter Chiba Barbara Tell Walter Jger Elisabeth Richter Manuela Hitzlera Gerhard Ecker 《Archiv der Pharmazie》1997,330(11):343-347
A series of 5-hydroxy and 5-benzyloxy analogs of the antiarrhythmic and multidrug resistance (MDR) modulating drug propafenone was synthesized and the MDR-modulating activity of the compounds was evaluated using a daunomycin efflux assay system. The key step of the synthesis is the selective reduction of the double bond in 1 without cleavage of the benzyl group thus leading to the phenol 3 . Alkylation with epichlorohydrine followed by nucleophilic epoxide ring opening gave the benzylated target compounds 5a–d . Subsequent cleavage of the benzyl group gave the 5-hydroxy analogs 6a–d . Structure activity relationship studies showed, that the 5-hydroxy derivates 6a–d fit the log P/log potency correlation line previously established for a series of propafenone analogs. In contrast, all four 5-benzyloxy analogs 5a–d showed almost identical EC50 values, independent of their log P value. 相似文献
9.
Inborn errors of the urea cycle are an important cause of hyperammonaemia throughout childhood, and are associated with high morbidity and mortality rates. If they are diagnosed early and treated appropriately, the outcome for affected children is significantly improved. 相似文献
10.