全文获取类型
收费全文 | 889篇 |
免费 | 41篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 11篇 |
妇产科学 | 18篇 |
基础医学 | 75篇 |
口腔科学 | 14篇 |
临床医学 | 79篇 |
内科学 | 129篇 |
皮肤病学 | 8篇 |
神经病学 | 27篇 |
特种医学 | 126篇 |
外科学 | 156篇 |
综合类 | 14篇 |
预防医学 | 36篇 |
眼科学 | 2篇 |
药学 | 32篇 |
肿瘤学 | 182篇 |
出版年
2023年 | 6篇 |
2021年 | 10篇 |
2020年 | 11篇 |
2019年 | 11篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 12篇 |
2015年 | 13篇 |
2014年 | 22篇 |
2013年 | 33篇 |
2012年 | 27篇 |
2011年 | 46篇 |
2010年 | 34篇 |
2009年 | 35篇 |
2008年 | 35篇 |
2007年 | 40篇 |
2006年 | 40篇 |
2005年 | 48篇 |
2004年 | 65篇 |
2003年 | 35篇 |
2002年 | 30篇 |
2001年 | 37篇 |
2000年 | 30篇 |
1999年 | 37篇 |
1998年 | 20篇 |
1997年 | 12篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 11篇 |
1993年 | 14篇 |
1992年 | 12篇 |
1991年 | 19篇 |
1990年 | 16篇 |
1989年 | 10篇 |
1988年 | 16篇 |
1987年 | 12篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1975年 | 3篇 |
1974年 | 7篇 |
1973年 | 3篇 |
1972年 | 4篇 |
排序方式: 共有941条查询结果,搜索用时 15 毫秒
1.
2.
3.
K E Wallner D Nori M J Morse P C Sogani W F Whitmore Z Fuks 《The Journal of urology》1990,144(3):704-706
We treated 13 patients with a second 125iodine implant for local recurrence of prostatic carcinoma. All patients had biopsy proved palpable recurrence without evidence of distant metastases. Full doses of irradiation were used (median matched peripheral dose 170 Gy.). Six patients had complete regression of palpable recurrence, 2 had partial regression, 2 had no apparent response and 3 were unevaluable for local response. Actuarial freedom from local disease progression at 5 years was 51%. Despite a relatively high rate of local disease control the actuarial rate of distant metastases reached 100% at 6 years after reimplantation. There were 2 severe rectal complications and 4 instances of mild to moderate urinary incontinence among the 13 patients. Local regression of recurrent prostatic carcinoma may be achieved with 125iodine reimplantation but most patients still had distant metastases. 相似文献
4.
Prischl F; Weber T; Lenglinger F; Kirchgatterer A; Wallner M; Kramar R 《Nephrology, dialysis, transplantation》1997,12(9):1994-1996
5.
6.
7.
Initial subcutaneous embedding of the peritoneal dialysis catheter-a critical appraisal of this new implantation technique 总被引:1,自引:0,他引:1
Prischl F; Wallner M; Kalchmair H; Povacz F; Kramar R 《Nephrology, dialysis, transplantation》1997,12(8):1661-1667
Background: The objectives of this open non-randomized
study were to evaluate the impact of a new peritoneal catheter placement
technique on catheter maintenance, and complications possibly related to
the access, e.g. leakage, infectious complications, or drainage failure.
Method: In a routine clinical setting, a two-cuff
swan-neck catheter was implanted surgically, but its external segment was
embedded in a subcutaneous pouch initially without exit site to enable
uncontaminated wound healing and tight ingrowth of the cuffs. After 4 weeks
at the earliest the distal catheter tip was set free by a small incision
under local anaesthesia, and CAPD was started.
Results: Using this technique, 26 catheters were
implanted in 17 males and nine females (mean age 52.3±17.4,
range 19-83 years). The catheters were buried subcutaneously for a median
of 79.5 (mean±SD 132.2±157.2, range 28-675) days, and
were activated in 21 patients. No leaks were seen, and only one abdominal
wall abscess secondary to a haematoma was found. Long-term follow up (mean
duration of CAPD 467.0±338.1, range 32-1320 days) revealed a
very low overall incidence of infectious complications, i.e. 0.80 per
patient-year (1 episode per 14.9 patient-months), and the incidence of
catheter-related peritonitis amounted to 0.036 per patient-year (1 episode
per 27.2 patient-years), only. However, the postoperative course was
complicated by seromas in two of 26, and subcutaneous haematomas in 12 of
26 patients, five of which were revised surgically. At catheter activation,
fibrin thrombi were found in nine of 21 patients and two had to be
operated. Omental catheter obstruction was diagnosed in four patients, and
followed by omentectomy. No relationship was seen between thrombus
formation and omental obstruction and duration of subcutaneous embedment
(P=0.27 and P=0.5 respectively) or patient age (P=0.06 and P-0.13
respectively; Mann-Whitney-test). There was also no relationship with
primary omentectomy or haematoma. Conclusion: We
conclude that although the very low incidence of infectious episodes
favours the new technique, further improvement is necessary to decrease the
unacceptable rate of perioperative complications. Subcutaneous embedding of
the catheter may then be considered in patients with expected problems of
wound healing, and those who wish to be prepared for peritoneal dialysis in
time. 相似文献
8.
Oscillatory motion of the normal cervical spinal cord 总被引:2,自引:0,他引:2
9.
Effect of cisplatin resistance on cellular radiation response 总被引:2,自引:0,他引:2
K E Wallner G C Li 《International journal of radiation oncology, biology, physics》1987,13(4):587-591
Cisplatin-resistant tumors of the head and neck are generally resistant to irradiation. To determine whether the association between cisplatin (DDP) resistance and radiation resistance is a cellular phenomenon, we developed DDP-resistant Chinese hamster fibroblasts and studied their response to radiation. DDP resistance did not confer cross resistance to radiation. DDP-resistant cells did not demonstrate altered ability to repair sublethal or potentially lethal radiation damage. However, an isodose concentration of DDP did not inhibit repair of radiation damage in drug-resistant cells as readily as it did in drug-sensitive cells. The results suggest that cross resistance of tumors between DDP and radiation may be a result of the tumor microenvironment, rather than being a cellular phenomenon. Additionally, DDP may not inhibit the repair of radiation damage in DDP-resistant tumors. 相似文献
10.
Activation heat, activation metabolism and tension-related heat in frog semitendinosus muscles 总被引:11,自引:4,他引:11
E. Homsher W. F. H. M. Mommaerts N. V. Ricchiuti A. Wallner 《The Journal of physiology》1972,220(3):601-625
1. Frog semitendinosus muscles were stretched to various lengths beyond the rest length (l(0)) and their initial heat and isometric tension production were measured.2. As the overlap between the thick and thin filaments is reduced, the initial twitch heat and tension decline in a linear manner. At a point at which the twitch tension approaches zero, the initial heat is 30% of that seen at l(0). It is concluded that this heat is the activation heat and reflects the energetics of calcium release and reaccumulation. The initial heat at shorter sarcomere lengths appears to be the sum of the activation heat plus a heat production associated with the interaction of the thick and thin filaments.3. A similar relationship between heat and tension production is seen in tetanic contractions.4. The time course of activation heat production in a twitch can be resolved into two phases: a temperature insensitive (Q(10) < 1.3) ;fast' phase (with a time constant of 45 msec) and a temperature sensitive (Q(10) = 2.8) ;slow' phase (with a time constant of 330 msec at 0 degrees C).5. Measurements of the creatine phosphate (PC) hydrolysis by muscles contracting isometrically at various muscle lengths at and beyond l(0), indicate an enthalpy change of -11.2 kcal/mole PC hydrolysed. The enthalpy change for the ATP hydrolysis by muscles stretched so that little or no tension was produced with stimulation was -9.9 kcal/mole ATP hydrolysed. It is concluded that the net activation heat is produced by the hydrolysis of PC or ATP. 相似文献