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Angel González-Sistal M.D. Ph.D. Alicia Baltasar Sánchez M.D. 《Journal of digital imaging》2006,19(3):270-275
Purpose This study was conducted to evaluate the diagnostic usefulness of gray level parameters in order to distinguish healthy bone
from osteoblastic metastases on digitized radiographs.
Materials and methods Skeletal radiographs of healthy bone (n = 144) and osteoblastic metastases (n = 35) were digitized using pixels 0.175 mm in size and 4,096 gray levels. We obtained an optimized healthy bone classification
to compare with pathological bone: cortical, trabecular, and flat bone. The osteoblastic metastases (OM) were classified in
nonflat and flat bone. These radiological images were analyzed by using a computerized method. The parameters (gray scale)
calculated were: mean, standard deviation, and coefficient of variation (MGL, SDGL, and CVGL, respectively) based on gray
level histogram analysis. Diagnostic utility was quantified by measurement of parameters on healthy and pathological bone,
yielding quantification of area under the receiver operating characteristic (ROC) curve, AUC.
Results All three image parameters showed high and significant values of AUC when comparing healthy trabecular bone and nonflat bone
OM, showing MGL the best discriminatory ability (0.97). As for flat bones, MGL showed no ability to distinguish between healthy
and flat bone OM (0.50). This could be achieved by using SDGL or CVGL, with both showing a similar diagnostic ability (0.85
and 0.83, respectively).
Conclusion Our results show that the use of gray level parameters quantify healthy bone and osteoblastic metastases zones on digitized
radiographs. This may be helpful as a complementary method for differential diagnosis. Moreover, our method will allow us
to study the evolution of osteoblastic metastases under medical treatment. 相似文献
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F. Portugal A. Araújo C. Silva M. Campos A. Valentim 《Revista espa?ola de anestesiología y reanimación》2021,68(5):293-296
Erythromelalgia (EM) is a rare autosomal dominant neuropathy characterized by the combination of severe burning pain and erythematous warm extremities. Chronic pain control is most often unsuccessful and a completely effective therapy is yet to be identified. Recent studies have reported significant improvements in pain management using a combination of amitriptyline and ketamine in a topical formulation. We describe a 1-year follow-up pain control success case of a male patient with EM, proposed for topical use of a 2% Amitriptyline and 0.5% Ketamine gel. 相似文献
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Background: Hybrid, combined or mixed bariatric surgery is the combination of a degree of ‘malabsorption’ (as achieved by the intestinal bypass) with a ‘rrestriction’
(as achieved by gastric bypass or gastroplasty), thereby simultaneously reducing the absorption of fats in the small bowel
and decreasing the intake of food. Methods: A modification of the bilio-pancreatic diversion (BPD) with a duodenal switch
procedure, vertical lineal gastrectomy and preservation of the pylorus, has been used in 23 patients. The antropyloric pump
and 4 cm of the duodenum are left intact to preserve physiologic gastric emptying and to prevent anastomotic ulcer. The use
of staplers and continuous running sutures reduces surgical risks and operative time. Results: One patient, converted from
a vertical gastroplasty, had an intrathoracic esophageal perforation and died of multisystemic organ failure, a mortality
rate of 4.5%. One patient had a partial dehiscence of the laparotomy wound. Three patients developed subcutaneous seromas.
Mean weight losses during the first 4 months were 13, 11, 6 and 5 kg, with a loss of 70% of excess weight in patients approaching
1 year. No patient needs treatment for diarrhea. No serious secondary side-effects have been detected. Conclusion: This operation
appears to result in very satisfactory weight loss, improved quality of life, and a low incidence of complications. 相似文献
5.
Residual and acute effects of flurazepam and triazolam were studied in two double-blind, crossover, placebo controlled, single-dose experiments. Psychological and physiological effects were determined 10 h after night administration (flurazepam 30 mg and triazolam 0.5 mg), and for 6 h after morning ingestion (flurazepam 15 mg and triazolam 0.25 mg). Both drugs produced similar "hangover" effects, impairing motor performance and increasing sleepiness on the following morning. After morning administration pronounced sedative effects were found with triazolam, while flurazepam effects were mild and hard to distinguish from placebo. The clinical relevance of these findings is discussed, suggesting that these drugs may be conceived as belonging to two different types of hypnotic agents. 相似文献
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Benigno Casanueva Baltasar Rodero Covadonga Quintial Javier Llorca Miguel A. González-Gay 《Rheumatology international》2013,33(10):2665-2670
The purpose of this study was to evaluate the short-term efficacy of topical capsaicin treatment in patients severely affected by fibromyalgia. One hundred and thirty fibromyalgia patients were randomly divided into two groups. The control group, 56 women and 4 men who continued their medical treatment, and the capsaicin group, 70 women who apart from continuing their medical treatment, also underwent topical capsaicin 0.075 % 3 times daily for 6 weeks. At the beginning of the program, there were no significant differences between the two groups in any of the analyzed parameters. At the end of the treatment, there were significant improvements in the capsaicin group in the myalgic score (5.21 vs 3.8, p = 0.02) and global subjective improvement (22.8 vs 5 %, p = 0.001). Six weeks after the end of the treatment, the experimental group showed significant differences in Visual Analogue Scale of depression (5.63 vs 7.35, p = 0.02), Fibromyalgia Impact Questionnaire (67.89 vs 77.7, p = 0.02), role limitations due to emotional problems (36.17 vs 17.2, p = 0.05), Fatigue Severity Scale (6.2 vs 6.6, p = 0.04), myalgic score (3.94 vs 2.66, p = 0.02) and pressure pain threshold (79.25 vs 56.71, p = 0.004). In conclusion, patients severely affected by fibromyalgia can obtain short-term improvements following topical capsaicin 0.075 % treatment three times daily for 6 weeks. 相似文献
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