全文获取类型
收费全文 | 132篇 |
免费 | 4篇 |
专业分类
儿科学 | 5篇 |
妇产科学 | 19篇 |
基础医学 | 22篇 |
临床医学 | 12篇 |
内科学 | 18篇 |
皮肤病学 | 1篇 |
神经病学 | 8篇 |
特种医学 | 3篇 |
外科学 | 14篇 |
综合类 | 1篇 |
预防医学 | 22篇 |
药学 | 10篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 1篇 |
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2012年 | 1篇 |
2011年 | 4篇 |
2010年 | 2篇 |
2009年 | 1篇 |
2008年 | 2篇 |
2007年 | 3篇 |
2006年 | 5篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 4篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1993年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 11篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1970年 | 9篇 |
1969年 | 5篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1966年 | 3篇 |
1965年 | 1篇 |
排序方式: 共有136条查询结果,搜索用时 31 毫秒
1.
Regina Felső Éva Lányi Éva Erhardt Zsófia Laufer Dániel Kardos Róbert Herczeg Attila Gyenesei Katalin Hollódy Dénes Molnár 《Journal of sleep research》2023,32(2):e13746
Ghrelin, a regulator of food intake and energy expenditure, has been shown to be associated with insufficient sleep. The goal of the present study was to investigate the effect of a single night of total sleep deprivation on fasting saliva ghrelin and on nocturnal variation of saliva ghrelin concentration. A further aim of the study was to investigate the influence of body mass index on changes in saliva ghrelin levels. Altogether 35 adolescents (18 boys; age: 13.8 ± 1.14 years) were studied on two subsequent days (sleep and total sleep deprivation). Saliva samples were collected during the two experimental nights at 21:00 hours, 01:00 hours and 06:00 hours. Total-ghrelin concentration showed a continuous increase from the evening until 06:00 hours. This increase was blunted significantly (p = 0.003) by total sleep deprivation. Total-ghrelin level was significantly lower (p = 0.02) during total sleep deprivation at 06:00 hours (median 403.6 pg ml−1; 95% confidence interval: 343.1–468.9 pg ml−1) as compared with values during the sleep condition (median 471.2 pg ml−1; 95% confidence interval: 205.4–1578.7 pg ml−1). Acyl-ghrelin levels did not present any change at the three time points, and were not affected by total sleep deprivation. Stratifying the study population according to body mass index (normal weight and overweight/obese groups), the blunting effect of total sleep deprivation was more pronounced in the obese/overweight group (sleep: median 428.2 pg ml−1; 95% confidence interval: 331.3–606.9 pg ml−1 versus total sleep deprivation: median 333.1 pg ml−1; 95% confidence interval: 261.5–412.9 pg ml−1; p = 0.0479). Saliva total-ghrelin concentrations gradually increased during the night, and total sleep deprivation significantly blunted this increase. This blunting effect was mainly observed in subjects with overweight/obesity. The physiological and clinical implications of the present observation are to be clarified by further studies. 相似文献
2.
3.
4.
Pham Daniel Polgar Beata Toth Tunde Jungling Adel Kovacs Norbert Balas Istvan Pal Endre Szabo Dora Fulop Balazs Daniel Reglodi Dora Szanto Zalan Herczeg Robert Gyenesei Attila Tamas Andrea 《Age (Dordrecht, Netherlands)》2022,44(2):785-803
GeroScience - The neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) have been shown in numerous in vitro and in vivo models of Parkinson’s disease (PD)... 相似文献
5.
Veronika N. Laine Gábor Herczeg Takahito Shikano Johanna Vilkki Juha Merilä 《Behavior genetics》2014,44(1):77-88
The genetic architecture of behavioral traits is yet relatively poorly understood in most non-model organisms. Using an F2-intercross (n = 283 offspring) between behaviorally divergent nine-spined stickleback (Pungitius pungitius) populations, we tested for and explored the genetic basis of different behavioral traits with the aid of quantitative trait locus (QTL) analyses based on 226 microsatellite markers. The behaviors were analyzed both separately (viz. feeding activity, risk-taking and exploration) and combined in order to map composite behavioral type. Two significant QTL—explaining on average 6 % of the phenotypic variance—were detected for composite behavioral type on the experiment-wide level, located on linkage groups 3 and 8. In addition, several suggestive QTL located on six other linkage groups were detected on the chromosome-wide level. Apart from providing evidence for the genetic basis of behavioral variation, the results provide a good starting point for finer-scale analyses of genetic factors influencing behavioral variation in the nine-spined stickleback. 相似文献
6.
Kemenesi Gábor Kornya László Tóth Gábor Endre Kurucz Kornélia Zeghbib Safia Somogyi Balázs A. Zöldi Viktor Urbán Péter Herczeg Róbert Jakab Ferenc 《Age (Dordrecht, Netherlands)》2020,42(4):1093-1099
GeroScience - The global impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is significant in terms of public health effects and its long-term socio-economic... 相似文献
7.
8.
Judit Simon Mohammed El Mahdiui Jeff M. Smit Lili Szraz Alexander R. van Rosendael Szilvia Herczeg Emese Zsarnczay Anik Ilona Nagy Mrton Kolossvry Blint Szilveszter Nndor Szegedi Klaudia Vivien Nagy Tams Tahin Lszl Gellr Rob J. van der Geest Jeroen J. Bax Pl MaurovichHorvat Bla Merkely 《Clinical cardiology》2022,45(3):273
IntroductionThere are no consistently confirmed predictors of atrial fibrillation (AF) recurrence after catheter ablation. Therefore, we aimed to study whether left atrial appendage volume (LAAV) and function influence the long‐term recurrence of AF after catheter ablation, depending on AF type.MethodsAF patients who underwent point‐by‐point radiofrequency catheter ablation after cardiac computed tomography (CT) were included in this analysis. LAAV and LAA orifice area were measured by CT. Uni‐ and multivariable Cox proportional hazard regression models were performed to determine the predictors of AF recurrence.ResultsIn total, 561 AF patients (61.9 ± 10.2 years, 34.9% females) were included in the study. Recurrence of AF was detected in 40.8% of the cases (34.6% in patients with paroxysmal and 53.5% in those with persistent AF) with a median recurrence‐free time of 22.7 (9.3–43.1) months. Patients with persistent AF had significantly higher body surface area‐indexed LAV, LAAV, and LAA orifice area and lower LAA flow velocity, than those with paroxysmal AF. After adjustment left ventricular ejection fraction (LVEF) <50% (HR = 2.17; 95% CI = 1.38–3.43; p < .001) and LAAV (HR = 1.06; 95% CI = 1.01–1.12; p = .029) were independently associated with AF recurrence in persistent AF, while no independent predictors could be identified in paroxysmal AF.ConclusionThe current study demonstrates that beyond left ventricular systolic dysfunction, LAA enlargement is associated with higher rate of AF recurrence after catheter ablation in persistent AF, but not in patients with paroxysmal AF. 相似文献
9.
10.