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1.
Vaccination of pregnant dams with intimin(O157) protects suckling piglets from Escherichia coli O157:H7 infection 总被引:3,自引:0,他引:3 下载免费PDF全文
Dean-Nystrom EA Gansheroff LJ Mills M Moon HW O'Brien AD 《Infection and immunity》2002,70(5):2414-2418
Cattle are important reservoirs of enterohemorrhagic Escherichia coli (EHEC) O157:H7 that cause disease in humans. Both dairy and beef cattle are asymptomatically and sporadically infected with EHEC. Our long-term goal is to develop an effective vaccine to prevent cattle from becoming infected and transmitting EHEC O157:H7 to humans. We used passive immunization of neonatal piglets (as a surrogate model) to determine if antibodies against EHEC O157 adhesin (intimin(O157)) inhibit EHEC colonization. Pregnant swine (dams) with serum anti-intimin titers of < or =100 were vaccinated twice with purified intimin(O157) or sham-vaccinated with sterile buffer. Intimin(O157)-specific antibody titers in colostrum and serum of dams were increased after parenteral vaccination with intimin(O157). Neonatal piglets were allowed to suckle vaccinated or sham-vaccinated dams for up to 8 h before they were inoculated with 10(6) CFU of a Shiga toxin-negative (for humane reasons) strain of EHEC O157:H7. Piglets were necropsied at 2 to 10 days after inoculation, and intestinal samples were collected for determination of bacteriological counts and histopathological analysis. Piglets that ingested colostrum containing intimin(O157)-specific antibodies from vaccinated dams, but not those nursing sham-vaccinated dams, were protected from EHEC O157:H7 colonization and intestinal damage. These results establish intimin(O157) as a viable candidate for an EHEC O157:H7 antitransmission vaccine. 相似文献
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Because yoga practitioners think they are benefiting from their breath training we hypothesized that yoga respiration training (YRT) could modify the respiratory sensation. Yoga respiration (YR) ("ujjai") consisted of very slow, deep breaths (2-3 min(-1)) with sustained breath-hold after each inspiration and expiration. At inclusion in the study and after a 2-month YRT program, we determined in healthy subjects their eupneic ventilatory pattern and their capacity to discriminate external inspiratory resistive loads (respiratory sensation), digital tactile mechanical pressures (somesthetic sensation) and sound-pressure stimulations (auditory sensation). Data were compared to a gender-, age-, and weight-matched control group of healthy subjects who did not undergo the YRT program but were explored at the same epochs. After the 2-month YRT program, the respiratory sensation increased. Thus, both the exponent of the Steven's power law (Psi=kPhin) and the slope of the linear-linear plot between Psi and mouth pressure (Pm) were significantly higher, and the intercept with ordinate axis of the Psi versus Pm relationship was lower. After YRT, the peak Pm developed against inspiratory loads was significantly lower, reducing the load-induced activation of respiratory afferents. YRT induced long-lasting modifications of the ventilatory pattern with a significant lengthening of expiratory duration and a modest tidal volume increase. No significant changes in somesthetic and auditory sensations were noted. In the control group, the respiratory sensation was not modified during a 15-min period of yoga respiration, despite the peak Pm changes in response to added loads were then significantly reduced. These data suggest that training to yoga respiration selectively increases the respiratory sensation, perhaps through its persistent conditioning of the breathing pattern. 相似文献
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Cervical preparation with laminaria reduces complications with 2nd trimester dilation and evacuation. During a surgical abortion at 22 weeks, we could not remove laminaria manually or with ring forceps due to laminaria “dumbbelling” [1]. Without pushing laminaria into the uterus, we mechanically dilated the cervix and removed the incarcerated laminaria. 相似文献
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Melody R. Palmer Daniel S. Kim David R. Crosslin Ian B. Stanaway Elisabeth A. Rosenthal David S. Carrell David J. Cronkite Adam Gordon Xiaomeng Du Yatong K. Li Marc S. Williams Chunhua Weng Qiping Feng Rongling Li Sarah A. Pendergrass Hakon Hakonarson David Fasel Sunghwan Sohn Patrick Sleiman Samuel K. Handelman Elizabeth Speliotes Iftikhar J. Kullo Eric B. Larson Gail P. Jarvik 《Genetic epidemiology》2021,45(1):4-15
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Melody Okereke Nelson Ashinedu Ukor Yusuff Adebayo Adebisi Isaac Olushola Ogunkola Eseosa Favour Iyagbaye Greatman Adiela Owhor Don Eliseo Lucero‐Prisno 《The International journal of health planning and management》2021,36(1):13-17
The COVID‐19 pandemic continues to be a major public health threat globally and low‐ and middle‐income countries (LMICs) are not an exception. The impact of the COVID‐19 pandemic is far‐reaching on many areas including but not limited to global health security, economic and healthcare delivery with a potential impact on access to healthcare in LMICs. We evaluate the impact of the COVID‐19 pandemic on access to healthcare in LMICs, as well as plausible strategies that can be put in place to ensure that the delivery of healthcare is not halted. In order to mitigate the devastating effect of the COVID‐19 pandemic on the already weak health systems in LMICs, it is much necessary to reinforce and scale up interventions and proactive measures that will ensure that access to healthcare is not disrupted even in course of the pandemic. 相似文献
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Frequency of the ATM IVS10-6T→G variant in Australian multiple-case breast cancer families 下载免费PDF全文
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Heart failure is a progressive illness that carries significant morbidity and mortality. This highly prevalent illness leads
to frequent, costly hospitalizations with approximately 50% of patients being readmitted within 6 months of initial hospitalization.
While rehospitalization has been extensively studied in the past, little progress has been made in terms of reducing readmission
rates of heart failure patients in the last decade despite increasing costs with impending resource limitations. We discuss
disease-centered, physician-centered, and patient-centered factors that lead to rehospitalization as well as community/resource
availability factors that contribute to rehospitalization of patients suffering from chronic heart failure. In addition, predictors
of hospitalization and interventions that reduce hospitalization will be critically evaluated. With a complete understanding
of heart failure rehospitalization, we hope the future holds more effective ways to prevent heart failure progression and
thus rehospitalization, improved risk-stratification models to identify patients high-risk for rehospitalization, and sustained
interventions that are customized according to the etiology of the clinical decline of heart failure patients that ultimately
results in frequent rehospitalizations. 相似文献