全文获取类型
收费全文 | 2327篇 |
免费 | 111篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 57篇 |
妇产科学 | 6篇 |
基础医学 | 407篇 |
口腔科学 | 44篇 |
临床医学 | 120篇 |
内科学 | 660篇 |
皮肤病学 | 114篇 |
神经病学 | 146篇 |
特种医学 | 38篇 |
外科学 | 280篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 38篇 |
眼科学 | 98篇 |
药学 | 210篇 |
中国医学 | 8篇 |
肿瘤学 | 211篇 |
出版年
2023年 | 5篇 |
2022年 | 5篇 |
2021年 | 15篇 |
2020年 | 14篇 |
2019年 | 18篇 |
2018年 | 29篇 |
2017年 | 28篇 |
2016年 | 33篇 |
2015年 | 22篇 |
2014年 | 29篇 |
2013年 | 64篇 |
2012年 | 89篇 |
2011年 | 115篇 |
2010年 | 58篇 |
2009年 | 60篇 |
2008年 | 119篇 |
2007年 | 131篇 |
2006年 | 145篇 |
2005年 | 150篇 |
2004年 | 141篇 |
2003年 | 149篇 |
2002年 | 148篇 |
2001年 | 93篇 |
2000年 | 77篇 |
1999年 | 89篇 |
1998年 | 49篇 |
1997年 | 37篇 |
1996年 | 34篇 |
1995年 | 29篇 |
1994年 | 25篇 |
1993年 | 26篇 |
1992年 | 57篇 |
1991年 | 41篇 |
1990年 | 29篇 |
1989年 | 26篇 |
1988年 | 43篇 |
1987年 | 30篇 |
1986年 | 28篇 |
1985年 | 44篇 |
1984年 | 25篇 |
1983年 | 23篇 |
1982年 | 15篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 15篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1975年 | 5篇 |
1974年 | 5篇 |
1973年 | 4篇 |
排序方式: 共有2467条查询结果,搜索用时 15 毫秒
1.
Koji Saito Takashi Saito Sumio Kawada 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1176, 1179-1176, 1180
2.
3.
4.
Yoshinori Itoh Yutaka Kohgo Naoki Watanabe Yuji Kanisawa Sumio Sakamaki Minoru Takahashi Yasuo Hirayama Hiroyuki Ono Takeshi Himeno Yoshiro Niitsu 《Cancer science》1991,82(11):1203-1206
Human tumor–infiltrating lymphocytes (TILs) derived from pleural or ascitic fluid were incubated with recombinant interleukin 2 and transfected with human tumor necrosis factor (TNF) a gene by the lipofection procedure. The resulting TILs secreted significant amounts of TNF in the culture supernatant and exhibited cytotoxicity against established cell lines, such as K562 and Daudi, and autologous tumor cells. The TNF gene–transfected TILs exhibited an augmented killing of autologous tumor cells. 相似文献
5.
Histamine-type 2 antagonists (H2-blockers) as represented by cimentidine have been shown to adversely affect renal allograft function, particularly when coadministered
with cyclosporine, currently a major immunosuppressant. To determine whether or not a newer and more powerful H2-blocker, famotidine, would produce similar adverse effects, we assessed seven cyclosporine-treated renal allograft recipients
with regard to changes in their renal function on or off the H2-blocker over a one-week period. Neither the administration nor withdrawal of famotidine (20–40 mg/day) resulted in any significant
changes in serum creatine, BUN, urine output or cyclosporine trough levels, suggesting that famotidine can be safely administered
as an H2-blocker to cyclosporine-treated renal allograft recipients. 相似文献
6.
Kohji Matsushita Kazuo Kitagawa Tomohiro Matsuyama Toshiho Ohtsuki Akihiko Taguchi Kenji Mandai Takuma Mabuchi Yoshiki Yagita Takehiko Yanagihara Masayasu Matsumoto 《Brain research》1996,743(1-2)
The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca2+-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripherally injected zinc on delayed neuronal death seen in the hippocampus after transient global ischemia, in order to elucidate a possible beneficial role on zinc in ischemic neuronal cell death. Forty-five adult Mongolian gerbils of both sexes underwent transient bilateral clipping of the common carotid arteries for 3 min. In the pretreated animals, ZnCl2 (20 mg/kg) was injected subcutaneously once, 1 h before ischemia (superacute group; n=6) or twice at 24 and 48 h before ischemia (subacute group; n=14). Histological survey was carried out 3 days later by in situ DNA fragmentation method and 4 days later by hematoxylin-eosin staining by semiquantatively counting dead neurons in the CA1 sector. Subacute zinc pre-administration significantly reduced the nuclear damage and subsequent neuronal death; however, superacutely pre-administered zinc did not protect hippocampal neurons against ischemia but it did not aggravate the effect of ischemia, either. The present study suggested that transfer of exogenous zinc into the intracellular space is required for neuroprotection, presumably via the anti-endonuclease activity. 相似文献
7.
Shigeru Onodera Koji Saito Takafumi Saito Hitoshi Togashi Sumio Kawata Katsuaki Ukai Haruhide Shinzawa 《Nihon Shokakibyo Gakkai zasshi》2007,104(2):213-218
It is well known that long-term infection with Clonorchis sinensis often causes bile duct cancer, usually. It occurs in the intrahepatic bile duct. We encountered a rare case of clonorchiasis complicated with duodenal papillary cancer. The patient was a woman from China. Although clonorchiasis is rarely found in Japan, the promotion of international exchange may increase the number of visitors from endemic areas. Thus we must pay sufficient attention to this disease. Also, we reported that the microplate ELISA technique was useful in the diagnosis of clonorchiasis with high accuracy in this case. 相似文献
8.
Introduction: One of the causes of pain during insertion of the colonoscope is stretching of the mesenterium by loop formation. The degree of pain differs according to the type of loop formation. Our aims were to study the accuracy of the colonoscopist’s assessment of the presence and type of loop formation and to study the degree of pain in relation to the type of loop by administering the visual analog scale (VAS). Methods: Two hundred and fifty‐seven consecutive patients were enrolled. All procedures were performed by two experienced colonoscopists who were blind to magnetic endoscope imaging view. After the colonoscopy, the colonoscopist was asked to assess the presence and type of loop formation. The degree of pain was assessed using the VAS. Results: The accuracy of estimating N loop, alpha loop, absence of loop formation and U loop was each over 70%. The accuracy of estimating gamma and splenic loop was significantly lower than the accuracy of estimating U loop. Colonoscopy was significantly more painful in women than in men. The degree of pain was significantly higher upon formation of reverse alpha loop and gamma and splenic loop than upon formation of N loop and U loop. Conclusions: Upon formation of reverse alpha loop or gamma and splenic loop, patients experienced more pain and it was difficult for the endoscopists to assess these loops. As women had severe pain compared with men, the use of a pediatric colonoscope or higher dosage of sedation in women should be considered. 相似文献
9.
10.