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Sudhakara Reddy Lingam Amara Swapna Tatipudi Ramesh Takur Rajesh Singh Koppolu Pradeep 《Journal of investigative and clinical dentistry》2012,3(4):298-303
Aim: To determine the influence of smoking on the blood and salivary superoxide dismutase levels among smokers, and to demonstrate the significance in alterations in the levels of superoxide dismutase in association with patient age, periodontal disease status, and duration and smoking frequency. Methods: Sixty healthy male patients (aged 20–60 years) constituted the target population. Blood and saliva samples were collected, and the periodontal index was measured using a Community Periodontal Index probe. Blood and salivary superoxide dismutase levels were calculated with the reagents prepared, and values were measured in a UV spectrophotometer. Results: There was a significant decrease in mean superoxide dismutase levels with an increase in age and smoking duration and frequency (0.23–0.05 U/mL). There was a range of 0.31–0.06 U/mL variation in the mean superoxide dismutase levels as the periodontal disease condition deteriorated. Conclusions: There was a significant reduction in the superoxide dismutase levels in the blood and saliva of smokers with increased duration and frequency of smoking, and as the periodontal disease condition worsened. Thus, this study emphasizes the importance of saliva as an easy, non‐invasive procedure in the diagnosis of patients who are more prone to precancerous lesions and conditions, and its importance in patient education and motivation programs for smoking cessation. 相似文献
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Gutti Ramasubrahmanyam Goli Nagasaina Rao Madasu Sudhakara Rao Biju Anand 《Indian Journal of Thoracic and Cardiovascular Surgery》2007,23(2):156-158
Off-pump Coronary bypass surgery gained popularity and became routine in many centres. Introduction of suction type myocardial
stabilizers made off-pump coronary surgery (OPCAB)safe. These stabilize myocardium locally but unusually produce a complication
of extensive subepicardial hematoma with rupture. This can be managed with compressive obliteration of subepicardial space
at the site of initial origin of hematoma with absorbable gelatin sponge and pericardium. 相似文献
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Ramalingam Peraman Devanna Nayakanti Hari Hara Theja Dugga Sudhakara Kodikonda 《Scientia pharmaceutica》2013,81(4):1017-1028
A validated stability-indicating RP-HPLC method for etofenamate (ETF) was developed by separating its degradation products on a C18 (250 mm × 4.6 mm 5 μm) Qualisil BDS column using a phosphate buffer (pH-adjusted to 6.0 with orthophosphoric acid) and methanol in the ratio of 20:80 % v/v as the mobile phase at a flow rate of 1.0 mL/min. The column effluents were monitored by a photodiode array detector set at 286 nm. The method was validated in terms of specificity, linearity, accuracy, precision, detection limit, quantification limit, and robustness. Forced degradation of etofenamate was carried out under acidic, basic, thermal, photo, and peroxide conditions and the major degradation products of acidic and basic degradation were isolated and characterized by 1H-NMR, 13C-NMR, and mass spectral studies. The mass balance of the method varied between 92–99%. 相似文献
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Malassezia pachydermatis is the most common causative organism for development of Malassezia dermatitis in dogs. An adult pug was presented to the clinic with chronic skin abnormalities, rancid odour from the body and pruritus. Lesion distribution was noticed on the ventral chin, neck, abdomen and inner surface of the legs. Skin scrapings, hair plucks and tape impression smears were examined, and footprint-shaped Malassezia organisms were identified in impression smears. Blood was collected to diagnose underlying factor for development of chronic recurrent Malassezia dermatitis. Up on blood tests, lowered total T4 (2.02 μg/dL) and free T4 (0.68 ng/dL) were detected. Treatment was given with oral ketoconazole (5-mg/kg body weight) resulted in improvement of clinical signs within two weeks of therapy. Thyroxine (at 20-μg/kg body weight BID, PO) was administered, and thyroxine levels in blood were in between the normal range after 2 months. No recurrence of dermatitis and pruritus was observed during the observatory period of six months. 相似文献
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Mukherjee Arkadeep Thakur Bharti Pandey Ajay Kumar Marmeisse Roland Fraissinet-Tachet Laurence Reddy M. Sudhakara 《Ecotoxicology (London, England)》2021,30(1):67-79
Ecotoxicology - The microbiota inhabiting in metal polluted environment develops strong defense mechanisms to combat pollution and sustain life. Investigating the functional genes of the eukaryotic... 相似文献
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The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
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Alymova IV Portner A Takimoto T Boyd KL Babu YS McCullers JA 《Antimicrobial agents and chemotherapy》2005,49(1):398-405
An association exists between respiratory viruses and bacterial infections. Prevention or treatment of the preceding viral infection is a logical goal for reducing this important cause of morbidity and mortality. The ability of the novel, selective parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 to prevent the synergism between a paramyxovirus and Streptococcus pneumoniae was examined in this study. A model of secondary bacterial pneumonia after infection with a recombinant Sendai virus whose hemagglutinin-neuraminidase gene was replaced with that of human parainfluenza virus type 1 [rSV(hHN)] was established in mice. Challenge of mice with a sublethal dose of S. pneumoniae 7 days after a sublethal infection with rSV(hHN) (synergistic group) caused 100% mortality. Bacterial infection preceding viral infection had no effect on survival. The mean bacterial titers in the synergistic group were significantly higher than in mice infected with bacteria only. The virus titers were similar in mice infected with rSV(hHN) alone and in dually infected mice. Intranasal administration of BCX 2798 at 10 mg/kg per day to the synergistic group of mice starting 4 h before virus infection protected 80% of animals from death. This effect was accompanied by a significant reduction in lung viral and bacterial titers. Treatment of mice 24 h after the rSV(hHN) infection showed no protection against synergistic lethality. Together, our results indicate that parainfluenza viruses can prime for secondary bacterial infections. Prophylaxis of parainfluenza virus infections with antivirals might be an effective strategy for prevention of secondary bacterial complications in humans. 相似文献
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Sudhakara Gujjala Mallaiah Putakala Srinivasulu Nukala Manjunatha Bangeppagari Rajendran Ramaswamy Saralakumari Desireddy 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2016,24(3):586
The current study was designed to evaluate the renoprotective effect of hydro-alcoholic extract of Caralluma fimbriata (CFE) against high-fat diet-induced oxidative stress in Wistar rats. Male Wistar rats were randomly divided into five groups: control (C), control treated with CFE (C + CFE), high-fat diet fed (HFD), high-fat diet fed treated with CFE (HFD + CFE), and high-fat diet fed treated with metformin (HFD + metformin). CFE was orally administered (200 mg/kg body weight) to Groups C + CFE and HFD + CFE rats for 90 days. Renal functional markers such as, urea, uric acid, and creatinine levels in plasma were quantified during the experimental period. At the end of the experimental period, activities of transaminases and oxidative stress markers, i.e., reduced glutathione (GSH), lipid peroxidation, protein oxidation, and activities of antioxidant enzymes were assayed in renal tissue. Coadministration of CFE along with HF-diet in Group HFD + CFE prevented the rise in the levels of plasma urea, uric acid, and creatinine, and elevated activities of renal transaminases with decreased protein content of Group HFD (p < 0.05). Establishment of oxidative stress in Group HFD, as evident from elevated lipid peroxidation, protein oxidation levels with depleted levels of GSH, and decreased activities of GSH dependent and independent antioxidant enzymes, was prevented in Groups HFD + CFE and HFD + metformin rats. Further, there were no deviations in the studied parameters but there was improved antioxidant status of Group C + CFE from Group C which revealed the nontoxic nature of CFE even under chronic treatment. Thus, CFE treatment effectively alleviated the HF-diet induced renal damage. Hence, this plant could be used as an adjuvant therapy for the prevention and/or management of HF-diet induced renal damage. 相似文献