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1.
Pieter Cornu Stephane Steurbaut Sabina Šoštarić Aleš Mrhar Alain G. Dupont 《International journal of clinical pharmacy》2014,36(3):519-525
Background Drug–drug interactions (DDIs) can lead to adverse drug events and compromise patient safety. Two common approaches to reduce these interactions in hospital practice are the use of clinical decision support systems and interventions by clinical pharmacists. Objective To compare the performance of both approaches with the main objective of learning from one approach to improve the other. Setting Acute geriatric ward in a university hospital. Methods Prospective single-centre, cohort study of patients admitted to the geriatric ward. An independent pharmacist compared the clinical decision support alerts with the DDIs identified by clinical pharmacists and evaluated their interventions. Contextual factors used by the clinical pharmacists for evaluation of the clinical relevance were analysed. Adverse drug events related to DDIs were investigated and the causality was evaluated by a clinical pharmacologist based on validated criteria. Main outcome measure Number of alerts, interventions and the acceptance rates. Results Fifty patients followed by the clinical pharmacists, were included. The clinical pharmacists identified 240 DDIs (median of 3.5 per patient) and advised a therapy change for 16 of which 13 (81.2 %) were accepted and three (18.8 %) were not. The decision support system generated only six alerts of which none were accepted by the physicians. Thirty-seven adverse drug events were identified for 29 patients that could be related to 55 DDIs. For two interactions the causality was evaluated as certain, for 31 as likely, for ten as possible and for 12 as unlikely. Mainly intermediate level interactions were related to adverse drug events. Contextual factors taken into account by the clinical pharmacists for evaluation of the interactions were blood pressure, international normalised ratio, heart rate, potassium level and glycemia. Additionally, the clinical pharmacists looked at individual administration intervals and drug sequence to determine the clinical relevance of the interactions. Conclusion Clinical pharmacists performed better than the decision support system mainly because the system screened only for high level DDIs and because of the low specificity of the alerts. This specificity can be increased by including contextual factors into the logic and by defining appropriate screening intervals that take into account the sequence in which the drugs are given. 相似文献
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Dvorackova Simona Mala-Ladova Katerina Zimcikova Eva Jirsova Eva Steurbaut Stephane Kubena Ales Antonin Kolar Jozef Maly Josef 《International journal of clinical pharmacy》2021,43(4):948-957
International Journal of Clinical Pharmacy - Background Oral anticoagulants are established drugs of choice for the prevention and treatment of thromboembolic events. However, monitoring their... 相似文献
3.
Maxim Grymonprez Andreas Capiau Tine L. De Backer Stephane Steurbaut Koen Boussery Lies Lahousse 《Clinical cardiology》2021,44(5):599
Although obesity is associated with the development and progression of atrial fibrillation (AF), an obesity paradox may be present, illustrated by seemingly protective effects of obesity on AF‐related outcomes. Body mass index (BMI) has an impact on outcomes in AF patients using oral anticoagulants. After searching Medline and Embase, meta‐analysis of results of four randomized and five observational studies demonstrated significantly lower risks of stroke or systemic embolism (RR 0.80, 95%CI [0.73–0.87]; RR 0.63, 95%CI [0.57–0.70]; and RR 0.42, 95%CI [0.31–0.57], respectively) and all‐cause mortality (RR 0.73, 95%CI [0.64–0.83]; RR 0.61, 95%CI [0.52–0.71]; and RR 0.56, 95%CI [0.47–0.66], respectively) in overweight, obese and morbidly obese anticoagulated AF patients (BMI 25 to <30, ≥30 and ≥40 kg/m2, respectively) compared to normal BMI anticoagulated AF patients (BMI 18.5 to <25 kg/m2). In contrast, thromboembolic (RR 1.92, 95%CI [1.28–2.90]) and mortality (RR 3.57, 95%CI [2.50–5.11]) risks were significantly increased in underweight anticoagulated AF patients (BMI <18.5 kg/m2). In overweight and obese anticoagulated AF patients, the risks of major bleeding (RR 0.86, 95%CI [0.76–0.99]; and RR 0.88, 95%CI [0.79–0.98], respectively) and intracranial bleeding (RR 0.75, 95%CI [0.58–0.97]; and RR 0.57, 95%CI [0.40–0.80], respectively) were also significantly lower compared to normal BMI patients, while similar risks were observed in underweight and morbidly obese patients. This meta‐analysis demonstrated lower thromboembolic and mortality risks with increasing BMI. However, as this paradox was driven by results from randomized studies, while observational studies rendered more conflicting results, these seemingly protective effects should still be interpreted with caution. 相似文献
4.
Grymonprez Maxim De Backer Tine L. Steurbaut Stephane Boussery Koen Lahousse Lies 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2022,36(4):749-761
Cardiovascular Drugs and Therapy - Oral anticoagulants are crucial for preventing systemic thromboembolism in atrial fibrillation (AF), with guidelines preferring non-vitamin K antagonist oral... 相似文献
5.
Moura Laura Steurbaut Stephane Salvesen Blix Hege Addison Brian Rabus Sule Mota-Filipe Hélder Alves da Costa Filipa 《International journal of clinical pharmacy》2022,44(1):118-126
International Journal of Clinical Pharmacy - Background Clinical activities provided by pharmacists are increasing worldwide, including in Europe. However, an overview of clinical pharmacy... 相似文献
6.
Dreischulte Tobias van den Bemt Bart Steurbaut Stephane 《International journal of clinical pharmacy》2022,44(4):837-842
International Journal of Clinical Pharmacy - Many definitions of the term clinical pharmacy exist, but a number of ambiguities remain. In order to clarify the European Society of Clinical Pharmacy... 相似文献
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8.
K. De Clercq I. De Leeuw B. Verheyden E. Vandemeulebroucke T. Vanbinst C. Herr E. Mroc G. Bertels N. Steurbaut C. Miry K. De Bleecker G. Maquet J. Bughin M. Saulmont M. Lebrun B. Sustronck R. De Deken J. Hooyberghs P. Houdart M. Raemaekers K. Mintiens P. Kerkhofs N. Goris F. Vandenbussche 《Transboundary and Emerging Diseases》2008,55(8):352-359
Until recently, bluetongue (BT) virus (BTV) serotypes reportedly causing transplacental infections were all ascribed to the use of modified live virus strains. During the 2007 BT epidemic in Belgium, a significant increase in the incidence of abortions was reported. A study including 1348 foetuses, newborns and young animals with or without suspicion of BTV infection, was conducted to investigate the occurrence of natural transplacental infection caused by wild‐type BTV‐8 and to check the immunocompetence of newborns. BTV RNA was present in 41% and 18.5% of aborted foetuses from dams with or without suspected BTV involvement during pregnancy, respectively. The results of dam/calf pairs sampled before colustrum uptake provide evidence of almost 10% transplacental BTV infection in newborns. Apparently immunotolerant calves were found at a level of 2.4%. The current study concludes that the combined serological and real‐time PCR (RT‐qPCR) result of pregnant dams gives no indication of the infection status of the offspring except in the case of a double negative result. In a group of 109 calves with clinical suspicion of BT, born during the vector‐free period, 11% were found to be RT‐qPCR positive. The true prevalence was estimated to be 2.3%, indicating the extent of transplacental infection in a group of 733 calves of one to 4 months of age without BT suspicion. Moreover, virus isolation was successful for two newborn calves, emphasizing the need for restricting trade to BT‐free regions of pregnant dams possibly infected during gestation, even if they are BTV RT‐qPCR negative. 相似文献
9.
Summary. During a single cycle infection with the neurovirulent GDVII- and demyelinating DA-strain of Theiler’s murine encephalomyelitis
virus (TMEV) in L-929 cells, different subviral particles were found for both strains. Early in the assembly process, the
DA-strain generated 14 S pentamers composed of the viral proteins VP0, VP1 and VP3, while in GDVII-infected cells, particles
with the same protein composition but with a sedimentation coefficient of 20 S were found. These newly discovered 20 S particles
are probably virion assembly precursors considering their capsid protein composition and their early time of appearance in
infected cells. Near the end of the assembly process, VP0, VP1 and VP3 containing 80 S empty capsids became apparent in GDVII-infected
cells, while these particles could not be found in DA-infected cells. The significance of these empty capsids will be discussed.
After virion assembly, 14 S particles were observed for both strains. These 14 S particles resulted from the degradation of
the 160 S virions as indicated by their protein composition (VP1, VP2, VP3) and time of appearance. Our results demonstrate
that the assembly of the GDVII-strain differs from that of the DA-strain. In addition, the strain-specific assembly of TMEV
implies that not all picornaviruses assemble as proposed by the poliovirus morphogenesis model and thus rendering its general
validity questionable.
Received October 14, 2002; accepted January 3, 2003
Published online March 21, 2003 相似文献
10.
Papastergiou John Kheir Nadir Ladova Katerina Rydant Silas De Rango Fabio Antoniou Sotiris Viola Reka Murillo Maria Dolores Steurbaut Stephane da Costa Filipa Alves 《International journal of clinical pharmacy》2018,40(1):202-202
International Journal of Clinical Pharmacy - In the original publication of this article, the article note has been missed and published online. 相似文献