全文获取类型
收费全文 | 8068篇 |
免费 | 494篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 253篇 |
妇产科学 | 148篇 |
基础医学 | 877篇 |
口腔科学 | 215篇 |
临床医学 | 601篇 |
内科学 | 1928篇 |
皮肤病学 | 141篇 |
神经病学 | 741篇 |
特种医学 | 391篇 |
外科学 | 1200篇 |
综合类 | 39篇 |
一般理论 | 1篇 |
预防医学 | 456篇 |
眼科学 | 45篇 |
药学 | 743篇 |
中国医学 | 17篇 |
肿瘤学 | 747篇 |
出版年
2023年 | 65篇 |
2022年 | 77篇 |
2021年 | 199篇 |
2020年 | 147篇 |
2019年 | 180篇 |
2018年 | 328篇 |
2017年 | 239篇 |
2016年 | 264篇 |
2015年 | 278篇 |
2014年 | 338篇 |
2013年 | 459篇 |
2012年 | 554篇 |
2011年 | 453篇 |
2010年 | 313篇 |
2009年 | 259篇 |
2008年 | 413篇 |
2007年 | 381篇 |
2006年 | 361篇 |
2005年 | 350篇 |
2004年 | 325篇 |
2003年 | 281篇 |
2002年 | 249篇 |
2001年 | 110篇 |
2000年 | 94篇 |
1999年 | 131篇 |
1998年 | 64篇 |
1997年 | 38篇 |
1996年 | 36篇 |
1995年 | 50篇 |
1994年 | 32篇 |
1993年 | 33篇 |
1992年 | 143篇 |
1991年 | 129篇 |
1990年 | 113篇 |
1989年 | 113篇 |
1988年 | 105篇 |
1987年 | 98篇 |
1986年 | 99篇 |
1985年 | 84篇 |
1984年 | 60篇 |
1983年 | 55篇 |
1982年 | 28篇 |
1981年 | 28篇 |
1980年 | 30篇 |
1979年 | 62篇 |
1978年 | 37篇 |
1973年 | 32篇 |
1970年 | 23篇 |
1969年 | 23篇 |
1968年 | 23篇 |
排序方式: 共有8601条查询结果,搜索用时 15 毫秒
1.
Quality of life in stroke survivor–caregiver dyads: a new conceptual framework and longitudinal study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
MEMRI and tumors: a method for the evaluation of the contribution of Mn(II) ions in the extracellular compartment
下载免费PDF全文
![点击此处可从《NMR in biomedicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eliana Gianolio Francesca Arena Enza Di Gregorio Roberto Pagliarin Martina Delbianco Gabriella Baio Silvio Aime 《NMR in biomedicine》2015,28(9):1104-1110
The purpose of the work was to set‐up a simple method to evaluate the contribution of Mn2+ ions in the intra‐ and extracellular tumor compartments in a MEMRI experiment. This task has been tackled by “silencing” the relaxation enhancement arising from Mn2+ ions in the extracellular space. In vitro relaxometric measurements allowed assessment of the sequestering activity of DO2A (1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid) towards Mn2+ ions, as the addition of Ca‐DO2A to a solution of MnCl2 causes a drop of relaxivity upon the formation of the highly stable and low‐relaxivity Mn‐DO2A. It has been proved that the sequestering ability of DO2A towards Mn2+ ions is also fully effective in the presence of serum albumin. Moreover, it has been shown that Mn‐DO2A does not enter cell membranes, nor does the presence of Ca‐DO2A in the extracellular space prompt migration of Mn ions from the intracellular compartment. On this basis the in vivo, instantaneous, drop in SE% (percent signal enhancement) in T1‐weighted images is taken as evidence of the sequestration of extracellular Mn2+ ions upon addition of Ca‐DO2A. By applying the method to B16F10 tumor bearing mice, T1 decrease is readily detected in the tumor region, whereas a negligible change in SE% is observed in kidneys, liver and muscle. The relaxometric MRI results have been validated by ICP‐MS measurements. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
4.
5.
6.
7.
8.
Is interleukin 2 a neuromodulator in the brain? 总被引:5,自引:0,他引:5
A bidirectional flow of information exists between the CNS and the neuroendocrine and immune systems, representing an important homeostatic mechanism in the body. Lymphokines and other products of immunocompetent cells seem to play a crucial role in this communication and seem to exert powerful effects on neurones in the brain. In this article, Giuseppe Nisticò and Giovambattista De Sarro describe the central effects following interleukin 2 (IL-2) microinfusion into several areas of the rat brain. The locus coeruleus seems to be the main site in the brain through which IL-2 exerts soporific effects. In addition, the possible transducing mechanisms coupling IL-2 receptor stimulation and the electroencephalogram (EEG) spectrum power responses elicited from the locus coeruleus seem to involve stimulation of specific receptors coupled to adenylate cyclase through a Gi protein. 相似文献
9.
Ehab Farag Maged Argalious Samer Narouze Glenn E. DeBoer Julie Tome 《Journal canadien d'anesthésie》2002,49(9):958-962
PURPOSE: To present the anesthetic management for the correction of a ventricular septal defect (VSD) in a patient with multiple acyl CoA dehydrogenase deficiency (glutaric aciduria type II; GAII). A review of the literature about anesthetic management of patients with mitochondrial diseases undergoing cardiopulmonary bypass (CPB) is also included. Clinical features: An 11-yr-old girl with GAII manifested as severe hypoglycemia since she was a newborn and generalized muscle weakness. She underwent open-heart surgery for VSD correction with CPB. The anesthetic management avoided inhalational anesthetics, maintained the blood sugar within normal limits and continued normothermia during CPB in order to avoid the stress of hypothermia for her abnormal mitochondria. The patient tolerated the procedure well and experienced a good recovery. CONCLUSION: The anesthetic management of patients with any mitochondrial disease requires normoglycemia, normothermia and the avoidance of metabolic stress in order to preserve energy production by the diseased mitochondria. 相似文献
10.