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排序方式: 共有149条查询结果,搜索用时 78 毫秒
1.
J Rajeev Shoba Srinath Y C J Reddy M G Shashikiran Satish Chandra Girimaji Shekhar P Seshadri D K Subbakrishna 《Revue canadienne de psychiatrie》2003,48(1):52-55
OBJECTIVE: Recent studies of patients with juvenile bipolar disorder report low rates of recovery and high rates of chronicity. However, we lack data on the short-term outcome. This study examines the pattern of recovery from the index episode in an aggressively treated juvenile sample. METHOD: We assessed 25 subjects (< 16 years) with a diagnosis of mania, using the Diagnostic Interview for Children and Adolescents-Revised) (DICA-R), Young Mania Rating Scale (YMRS), and Children's Global Assessment Scale (CGAS) at intake and at 3 and 6 months. We studied the time taken to recover from the index episode, the level of functioning, and the factors predicting them. RESULTS: After 6 months, 24 (96%) subjects had recovered from the index manic episode. The median time to recovery was 27 days. Total episode length was significantly longer among those with previous affective episodes. CONCLUSIONS: The findings suggest that juvenile-onset mania has high rates of recovery and low rates of chronicity. These differences from the existing literature need further exploration. 相似文献
2.
Yeo GS Connie Hung CC Rochford J Keogh J Gray J Sivaramakrishnan S O'Rahilly S Farooqi IS 《Nature neuroscience》2004,7(11):1187-1189
An 8-year-old male with a complex developmental syndrome and severe obesity was heterozygous for a de novo missense mutation resulting in a Y722C substitution in the neurotrophin receptor TrkB. This mutation markedly impaired receptor autophosphorylation and signaling to MAP kinase. Mutation of NTRK2, which encodes TrkB, seems to result in a unique human syndrome of hyperphagic obesity. The associated impairment in memory, learning and nociception seen in the proband reflects the crucial role of TrkB in the human nervous system. 相似文献
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Radilaite Cammock Daysha Tonumaipe’a Cath Conn Losi Sa’uLilo El-Shadan Tautolo Shoba Nayar 《Health policy (Amsterdam, Netherlands)》2021,125(2):229-238
New Zealand is currently facing an obesity and non communicable diseases (NCDs) epidemic. Recent studies have largely attributed these health issues to insufficient food and low-quality diets that cause micronutrient deficiencies. Improving healthy diets requires broader thinking and collaboration, particularly around maintaining sustainable food systems, which signifies a shift from individualistic/behavioural approaches in health promotion. This paper aims to extend solutions addressing increasing rates of obesity and diet-related NCDs in New Zealand while considering diet and human health in concurrence with sustainability. In particular, the three pillars of sustainability—economic, environmental, and social—will be considered, alongside application of a food systems approach to analysing the epidemic and policy developments in New Zealand. Given its proximity to smaller Pacific islands in the region, New Zealand is in a unique position to work multisectorally and be a leader in considering food system approaches to tackling obesity and NCDs in the Pacific. 相似文献
6.
Ing Ping Tang Shashinder Singh Nair Shoba Omar Rahmat Shailendra Shivalingam Krishnan G. Gopala Baharudin Khairuzzana 《Auris, nasus, larynx》2009
Ingested foreign bodies are a fairly common otorhinolaryngological emergencies encountered in Malaysia. The vast majority of these foreign bodies are fish bones which most commonly are impacted at the level of the cricopharynx. Rarely, however, a foreign body may migrate extraluminally and may even extrude subcutaneously. We report a rare occurrence where a fish bone not only migrated extraluminally, it was found to have migrated into the common carotid artery and the internal jugular vein and required surgical removal. 相似文献
7.
Meenakshi Hegde Malini Mukherjee Zakaria Grada Antonella Pignata Daniel Landi Shoba A. Navai Amanda Wakefield Kristen Fousek Kevin Bielamowicz Kevin K.H. Chow Vita S. Brawley Tiara T. Byrd Simone Krebs Stephen Gottschalk Winfried S. Wels Matthew L. Baker Gianpietro Dotti Maksim Mamonkin Malcolm K. Brenner Jordan S. Orange Nabil Ahmed 《The Journal of clinical investigation》2021,131(13)
8.
Shoba Amarnath 《European journal of immunology》2013,43(9):2255-2258
9.
Saman K. Hashmi Shoba A. Navai Tiffany M. Chambers Michael E. Scheurer M. John Hicks Rachel E. Rau Maria M. Gramatges 《Pediatric blood & cancer》2020,67(2)
Conjugated hyperbilirubinemia (CHB) and liver transaminase elevation are known complications of acute lymphoblastic leukemia (ALL) therapy, but host risk factors are poorly understood. Among 373 children diagnosed with ALL between 2011 and 2016, clinically significant CHB and transaminase elevation were observed in 15 (4.0%) and 12 (3.2%) children, respectively, during induction and consolidation. Body mass index ≥95th percentile (odds ratio 9.20, 95% confidence interval 2.56–32.96) was the only host factor independently associated with CHB, and no host factors were associated with transaminase elevation. Obese patients warrant closer monitoring of hepatic function to facilitate early intervention prior to the development of severe, adverse hepatic events. 相似文献
10.
Early detection has a central role in the prevention and management of mental retardation. The purpose of this present study
is to delinerate the characteristics of developmentally delayed infants and their families attending Mental Retardation Clinic.
The sample consisted of 101 infants who were registered in Mental Retardation Clinic of NIMHANS, Bangalore in 1988 constituting
12.5% of total registrations. Data was collected from case records.
Majority of subjects were males, first or second born, 7 months or older, from a consanguineous lower or middle class family.
Along with developmental delay, 60% had other complaints. Medical problems were reported in about half of the subjects and
most had abnormalities on physical examination. Aetiology was discernible in 77.1%. Majority had associated physical disorder
such as cerebral palsy, seizures and hearing and/or visual impairment. Around 17% came for follow-up thrice or more, 43% dropped
out after work-up.
The main conclusions are that; (i) certain socio-demographic, personal and clinical variables influence treatment seeking,
and (ii) developmental delay recognised in infancy tends to be associated with clear aetiologic factors and significant medical/neurologic
problems. 相似文献