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1.
Stepanova E. S. Makarenkova L. M. Chistyakov V. V. Rybakov Yu. L. Gukasov V. M. Fedotcheva T. A. Parshin V. A. Votyakov V. A. Shimanovskii N. L. 《Pharmaceutical Chemistry Journal》2019,52(12):1016-1020
Pharmaceutical Chemistry Journal - An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was... 相似文献
2.
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 5, pp. 540–549, May, 1989. 相似文献
3.
T. A. Fedotcheva N. L. Shimanovskii A. I. Senderovich N. S. Chermnykh A. V. Semeikin V. M. Rzheznikov L. E. Golubovskaya G. S. Grinenko V. V. Banin P. V. Sergeev 《Pharmaceutical Chemistry Journal》2007,41(7):345-349
The hormonal compound with the highest cytostatic activity against MCF-7 tumor cells (human breast cancer, BC) and the lowest
activity against normal cells (rat skin fibroblasts) was sought among gestagens, androstenes, and antiestrogencytostatics.
It was found that antiestrogencytostatics and androstenes had the highest cytostatic activity against tumor cells whereas
gestagens and antiestrogencytostatics were least active against fibroblasts. Studies of the activity of the hormonal compounds
in combination with doxorubicin on the viability of MCF-7 and rat skin fibroblasts found that all investigated compounds with
the exception of dehydroepiandrosterone (DHEA) intensify the cytostatic activity of doxorubicin against tumor cells, the greatest
effect seen for antiestrogencytostatics. A chemoprotective effect of androstenes on normal cells was noted.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 7, pp. 3–7, July, 2007. 相似文献
4.
5.
Shimanovskii NL Semeikin AV Fedotcheva TA Fedosov AV Kamernitskii AV Levina IS 《Bulletin of experimental biology and medicine》2002,134(4):385-388
Temporal and concentration dependencies of the effects of gestagens (6-methylpentarane and progesterone) and cytostatic doxorubicin on proliferation of MCF-7 and HeLa tumor cells was studied using 3H-thymidine test. Gestagens produced the maximum inhibitory effect of on cell proliferation in a concentration of 10-5 M; the effect developed on day 6 of incubation. 6 -Methylpentarane in a concentration of 10-8 inhibited proliferation of HeLa cells more effectively than progesterone (p<0.05). In experiments with combined treatment of doxorubicin-sensitive MCF-7 and HeLa cells, progesterone in a concentration of 10-7 M attenuated the cytostatic effect of doxorubicin (p<0.05), while 6-methylpentarane in the studied concentrations did not modulate it. 相似文献
6.
P. V. Sergeev Yu. K. Napolov E. V. Markina N. L. Shimanovskii 《Bulletin of experimental biology and medicine》1998,125(6):564-566
The study comparesin vitro effect of different contrast media on complement activity and eicosanoid content. Ionic agents (Bilignost>Iodamide>Triombrast>Hexabrix)
exert pronounced complement-activating effect, while nonionic agents markedly increase blood content of arachidonic acid metabolites.
The complement-activating effect of contrast media did not correlate with their ability to elevate blood content of prostaglandin
F2α and leukotrienes C4 and B4.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 637–640, June, 1998 相似文献
7.
8.
Akopdzhanov A. G. Shimanovskii N. L. Borisova A. I. Parshin V. A. Frolov G. A. 《Pharmaceutical Chemistry Journal》2020,53(12):1164-1167
Pharmaceutical Chemistry Journal - Ultra-small ferrite nanoparticles containing bivalent metal atoms (Fe, Mn, Mg, and Co) were synthesized as platforms for magnetic-resonance contrast agents... 相似文献
9.
Goizman M. S. Shimanovskii N. L. Zotova O. A. Ryzhkov I. O. Popova A. O. Chernobrovkin M. G. Korlyukov A. A. Suponitskii K. Yu. Sinel’nikov A. V. 《Pharmaceutical Chemistry Journal》2019,53(9):876-882
Pharmaceutical Chemistry Journal - Secondary patenting of organic compounds that can undoubtedly be used as active pharmaceutical ingredients (APIs) is discussed. As a rule, such compounds, their... 相似文献
10.
Fedotcheva T. A. Sheichenko O. P. Sheichenko V. I. Fedotcheva N. I. Shimanovskii N. L. 《Pharmaceutical Chemistry Journal》2019,53(1):57-64
Pharmaceutical Chemistry Journal - Escin-containing horse chestnut extracts and various medicinal formulations are widely used as venotonic agents whose mechanisms of action and intracellular... 相似文献