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排序方式: 共有576条查询结果,搜索用时 31 毫秒
1.
Koga T Hashimoto S Sugio K Yonemitsu Y Nakashima Y Yoshino I Matsuo Y Mojtahedzadeh S Sugimachi K Sueishi K 《American journal of clinical pathology》2002,117(3):464-470
We assessed the occurrence of atypical adenomatous hyperplasia (AAH) in whole lung lobes with primary cancer lesions. Following surgical resection, tissue specimens were sliced to a thickness of 4 mm (3,641 specimens from 61 cases; mean = 59.7 specimens per case). A total of 119 AAH foci were found and an association was evident in 25 (57%) of 44 adenocarcinomas, 3 (30%) of 10 squamous cell carcinomas, and 2 (29%) of 7 other lung cancers. Histologic evaluation showed that 108 AAH foci were categorized as low-grade and the other 11 as high-grade AAH. These 11 foci of high-grade AAH were present in 7 patients with adenocarcinoma, and in 1 patient there was a synchronous double primary lung adenocarcinoma. High-grade AAH was closely associated with bronchioloalveolar carcinoma (BAC) type adenocarcinoma, and low-grade AAH with non-BAC adenocarcinoma. The mean +/- SD Ki-67 labeling index in high-grade AAH (3.5%+/-2.9%) was significantly higher than for the low-grade index (1.4%+/-1.6%). We propose that foci of high- but not low-grade AAH may be potential precursor lesions of lung adenocarcinoma, especially with the BAC component. 相似文献
2.
Stefanie Kreutmair Susanne Unger Nicolás Gonzalo Núñez Florian Ingelfinger Chiara Alberti Donatella De Feo Sinduya Krishnarajah Manuel Kauffmann Ekaterina Friebel Sepideh Babaei Benjamin Gaborit Mirjam Lutz Nicole Puertas Jurado Nisar P. Malek Siri Goepel Peter Rosenberger Helene A. Häberle Ikram Ayoub Burkhard Becher 《Immunity》2021,54(7):1578-1593.e5
3.
Fatemeh Jahanian Iraj Goli Khatir Hamed Amini Ahidashti Sepideh Amirifard 《Ethiopian journal of health sciences》2021,31(2):267
BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are serious complications that often require immediate intervention in an emergency department (ED). The aim of this study was to investigate the effect of intravenous magnesium sulphate as an adjuvant in the treatment of AECOPD in the ED.MethodsIn a double-blind, randomized clinical trial, a total of 60 patients with AECOPD presenting to the ED of Imam Khomeini Hospital in Sari, Iran, were included. The study was conducted between September 2016 and February 2018. Eligible patients were randomly allocated into two groups of intervention and control. Patients in the intervention and control groups received intravenous infusion of magnesium sulfate (2 gr) or normal saline over 30 minutes, respectively. For all patients, Borgdyspnea score, forced expiratory volume in one second (FEV1) result and clinical variables of interest were evaluated before the beginning of the intervention, and also 45 minutes and 6 hours after the commencement of intervention.ResultsRegardless of time of evaluation, pulse rate (PR), respiratory rate (RR) and Borg score in intervention group was lower than control group. Also, FEV1 and SPO2 were greater in intervention group compared to control group. However, these differences were not statistically significant (between-subject differences or group effect) (p<0.001). The trends of FEV1, SPO2, PR, RR and Borg score were similar between two groups of study (no interaction effect; P>0.05).ConclusionAccording to the results of this study, it seems that using intravenous magnesium sulfate has no significant effect on SPO2, FEV1, RR, and PR of patients with AECOPD who presented to ED. 相似文献
4.
Bateni Sarah B. Gingrich Alicia A. Kirane Amanda R. Sauder Candice A. M. Gholami Sepideh Bold Richard J. Meyers Frederick J. Canter Robert J. 《Annals of surgical oncology》2021,28(3):428-428
Annals of Surgical Oncology - 相似文献
5.
Habib Sadeghirad Tayyeb Bahrami Sepideh M. Layeghi Hassan Yousefi Meysam Rezaei Seyed R. Hosseini-Fard Payar Radfar Majid E. Warkiani Ken O'Byrne Arutha Kulasinghe 《Immunology》2023,168(2):256-272
Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and has a 5-year survival rate of ~20%. Immunotherapies have shown promising results leading to durable responses, however, they are only effective for a subset of patients. To determine the best therapeutic approach, a thorough and in-depth profiling of the tumour microenvironment (TME) is required. The TME is a complex network of cell types that form an interconnected network, promoting tumour cell initiation, growth and dissemination. The stroma, immune cells and endothelial cells that comprise the TME generate a plethora of cytotoxic or cytoprotective signalling pathways. In this review, we discuss immunotherapeutic targets in NSCLC tumours and how the TME may influence patients' response to immunotherapy. 相似文献
6.
7.
Mandeep S. Sagoo Hemal Mehta Andrew J. Swampillai Victoria M.L. Cohen Sepideh Z. Amin P. Nicholas Plowman Sue Lightman 《Survey of ophthalmology》2014
Primary intraocular lymphoma (PIOL) is an ocular malignancy that is a subset of primary central system lymphoma (PCNSL). Approximately one-third of PIOL patients will have concurrent PCNSL at presentation, and 42–92% will develop PCNSL within a mean of 8–29 months. Although rare, the incidence has been rising in both immunocompromised and immunocompetent populations. The majority of PIOL is diffuse large B-cell lymphoma, though rare T-cell variants are described. Recently, PIOL has been classified by main site of involvement in the eye, with vitreoretinal lymphoma as the most common type of ocular lymphoma related to PCNSL. Diagnosis remains challenging for ophthalmologists and pathologists. PIOL can masquerade as noninfectious or infectious uveitis, white dot syndromes, or occasionally as other neoplasms such as metastatic cancers. Laboratory diagnosis by cytology has been much aided by the use of immunocytochemistry, flow cytometry, biochemical finding of interleukin changes (IL10:IL6 ratio > 1), and cellular microdissection with polymerase chain reaction amplification for clonality. Use of several tests improves the diagnostic yield. Approaches to treatment have centered on systemic methotrexate-based chemotherapy, often with cytarabine (Ara-C) and radiotherapy. Use of intravitreal chemotherapy with methotrexate (0.4 mg/0.1 mL) is promising in controlling ocular disease, and intravitreal rituximab (anti-CD20 monoclonal antibody) has also been tried. Despite these advances, prognosis remains poor. 相似文献
8.
9.
Shuang Lu Hong Sun Kim Yubo Cao Karan Bedi Lili Zhao Ishwarya Venkata Narayanan Brian Magnuson Yumei Gu Jing Yang Zhujun Yi Sepideh Babaniamansour Sargis Shameon Chang Xu Michelle T. Paulsen Ping Qiu Sivakumar Jeyarajan Mats Ljungman Dafydd Thomas Yali Dou Howard Crawford Marina Pasca di Magliano Kai Ge Bo Yang Jiaqi Shi 《International journal of cancer. Journal international du cancer》2023,153(3):552-570
10.
Sepideh N. Asadbeigi Lisheng Zhang Konstantinos Linos 《Journal of cutaneous pathology》2020,47(8):768-775
Desmoplastic small round-cell tumor (DSRCT) is a rare, aggressive malignant tumor, which in the great majority of cases arises at abdominal-pelvic sites. Nevertheless, rare cases of primary extra-abdominal tumors have been reported. In challenging cases, its molecular hallmark, the EWSR1-WT1 reciprocal translocation, can be exploited diagnostically by various molecular techniques. Herein, we report an extremely rare case of primary subcutaneous DSRCT in an effort to raise awareness among our dermatopathology colleagues by expanding the differential of superficial round-cell tumors. 相似文献