全文获取类型
收费全文 | 62篇 |
免费 | 1篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 5篇 |
基础医学 | 11篇 |
口腔科学 | 2篇 |
临床医学 | 1篇 |
内科学 | 14篇 |
神经病学 | 1篇 |
外科学 | 2篇 |
综合类 | 2篇 |
预防医学 | 7篇 |
药学 | 16篇 |
肿瘤学 | 1篇 |
出版年
2014年 | 1篇 |
2010年 | 1篇 |
2009年 | 3篇 |
2000年 | 1篇 |
1998年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1959年 | 12篇 |
1958年 | 5篇 |
1957年 | 6篇 |
1956年 | 7篇 |
1955年 | 7篇 |
1954年 | 5篇 |
1952年 | 1篇 |
排序方式: 共有63条查询结果,搜索用时 15 毫秒
1.
SANDOR BAJUSZ VALER J. CSERNUS TAMAS JANAKY LAZARO BOKSER MATYAS FEKETE ANDREW V. SCHALLY 《Chemical biology & drug design》1988,32(6):425-435
Modifications of the previously described LHRH antagonists, [Ac-d -Nal(2)1, d -Phe(4Cl)2, d -Trp3, d -Cit6, d -Ala10]LHRH and the corresponding d -Hci6 analogue, have been made to alter the hydrophobicity of the N-terminal acetyl-tripeptide portion. Substitution of d -Trp3 with the less hydrophobic d -Pal(3) had only marginal effects on the antagonistic activities and receptor binding potencies of the d -Cit/d -Hci6 analogues, but it appeared to further improve the toxicity lowering effect of d -Cit/d -Hci6 substitution. Antagonists containing d -Pal(3)3 and d -Cit/d -Hci6 residues, i.e. [Ac-d -Nal(2)1, d -Phe(4Cl)2, d -Pal(3)3d -Cit6, d -Ala10]LHRH (SB-75) and [Ac-d -Nal(2)1, d -Phe(4Cl)2, d -Pal(3)3, d -Hci6, d -Ala10]LHRH (SB-88), were completely free of the toxic effects, such as cyanosis and respiratory depression leading to death, which have been observed in rats with the d -Trp3, d -Arg6 antagonist and related antagonists. Replacement of the N-acetyl group with the hydrophilic carbamoyl group caused a slight decrease in antagonistic activities, particularly in vitro. Introduction of urethane type acyl group such as methoxycarbonyl (Moc) or t-butoxycarbonyl (Boc) led to analogues that showed LHRH-potentiating effect. The increase in potency induced by these analogues, e.g. [Moc-d -Nal(2)1, d -Phe(4Cl)2, d -Trp3, d -Cit6, d -Ala10]LHRH and [Boc-d -Phe1, d -Phe(4Cl)2, d -Pal(3)3, d -Cit6, d -Ala10]LHRH, was 170-260% and persisted for more than 2 h when studied in a superfused rat pituitary system. 相似文献
2.
3.
4.
5.
6.
7.
8.
9.
10.
TAMARA PRINGSHEIM MD ; ANTHONY LANG MD ; ROGER KURLAN MD ; MICHELLE PEARCE MD ; PAUL SANDOR MD 《Developmental medicine and child neurology》2009,51(6):468-472
The aim of this study was to understand how children with Tourette syndrome (TS), with or without attention-deficit-hyperactivity disorder (ADHD) and/or obsessive-compulsive disorder (OCD), experience disability. Children seen at two TS centres were eligible for participation. Clinicians compiled baseline information and symptom severity rating scales. Parents completed the Child Health Questionnaire, a measure of physical and psychosocial health. Seventy-one children (56 males, 15 females); mean age 11y 2mo [SD 3y 1mo], range 7−17y) were analyzed in the subgroups: TS only ( n =20), TS+ADHD ( n =22), TS+ADHD+OCD ( n =18), and TS+OCD ( n =11). Almost all psychosocial domain scores were significantly lower than national norms for the TS+ADHD and TS+ADHD+OCD subgroups ( p <0.001). For the TS only subgroup, only the family activities domain was significantly affected. Psychosocial summary scores were 53.2 for norms, 54.4 for the TS only subgroup ( ns ), 41.4 for the TS+ADHD subgroup ( p <0.001), 35.3 for the TS+ADHD+OCD subgroup ( p <0.001), and 35.5 for the TS+OCD group ( p =0.003). A multiple linear regression model including diagnosis, age, sex, and TS, OCD, and ADHD symptom severity found that the most significant predictor of the psychosocial summary score was ADHD symptom severity (R2 =0.55, p <0.001). Children with TS+ADHD±OCD experience impairment in all aspects of psychosocial health. For children with TS only, psychosocial health was not different from that of the normative population in the majority of domains tested. This suggests treatment of ADHD and OCD should be the priority in children with multiple diagnoses. 相似文献