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排序方式: 共有171条查询结果,搜索用时 15 毫秒
1.
Socorro Vanesca Frota Madeira Angela de Castro Resende Dayane Teixeira Ognibene Marcelo Augusto Vieira de Sousa Roberto Soares de Moura 《Pharmacological research》2005,52(4):321-327
An alcohol-free grape-skin extract (GSE) obtained from skins of Vitis labrusca has significant anti-hypertensive, antioxidant and vasodilator effects. According to our previous results, the vasodilator effect of GSE in the isolated mesenteric vascular bed (MVB) of the rat is dependent on endothelium and partially dependent on nitric oxide (NO). In the MVB of the rat pre-contracted with norepinephrine (NE), bolus injections of GSE induced a long-lasting dose-dependent vasodilation that is significantly reduced after the treatment with 1H-[1,2,3] oxadiazolo [4,4-a] quinoxalin-1-one (ODQ). Additionally, in vessels pre-contracted with norepinephrine and depolarized with KCl (25 mM) or treated with Ca(2+)-dependent K(+)-channel blockers charybdotoxin (ChTx) plus apamin, the vasodilator effect of GSE was significantly reduced and almost abolished by ChTx plus apamin plus L-NAME. However, the vasodilator effect of GSE was unaffected by D-Arg[Hyp(3),Thi(5),D-Tic(7),Oic(8)]bradykinin (HOE-140), atropine, yohimbine, pyrilamine and 4-aminopyridine (4-AP). The vasoconstriction response elicited by bolus injection of KCl was not affected by GSE, whereas the vasoconstrictor response induced by NE was dose-dependently and completed inhibited by GSE in the presence but not in the absence of endothelium. However, NE-induced vasoconstriction in calcium-free condition or without endothelium was not reduced by GSE. The present results demonstrate that GSE induces a vasodilator effect in the rat MVB, which is dependent on NO in combination with endothelium-derived hyperpolarizing factor (EDHF). Additionally, our results indicated that extracellular Ca(2+) has an important role on the endothelium-dependent vasodilator effect induced by GSE. 相似文献
2.
Ana Railka de Souza Oliveira Alice Gabrielle de Sousa Costa Huana Carolina Candido Morais Tahissa Frota Cavalcante Marcos Venícios de Oliveira Lopes Thelma Leite de Araujo 《Revista latino-americana de enfermagem》2015,23(2):216-224
Objective:
to investigate the association of risk factors with the Risk for aspiration nursing diagnosis and respiratory aspiration.Method:
cross-sectional study assessing 105 patients with stroke. The instrument used to collect data addressing sociodemographic information, clinical variables and risk factors for Risk for aspiration. The clinical judgments of three expert RNs were used to establish the diagnosis. The relationship between variables and strength of association using Odds Ratio (OR) was verified both in regard to Risk for aspiration and respiratory aspiration.Results:
risk for aspiration was present in 34.3% of the patients and aspiration in 30.5%. The following stood out among the risk factors: Dysphagia, Impaired or absent gag reflex, Neurological disorders, and Impaired physical mobility, all of which were statistically associated with Risk for aspiration. Note that patients who develop such a diagnosis were seven times more likely to develop respiratory aspiration.Conclusion:
dysphagia, Impaired or absent gag reflex were the best predictors both for Risk for aspiration and respiratory aspiration. 相似文献3.
Frota Filho JD Drews C Leães P Blacher C Tostes F Delatorre N Vieira M Lúcio E Pereira W Sales M Lobo R Stuermer R Tanaka N Portugal L Lucchese F 《Arquivos brasileiros de cardiologia》2001,76(3):245-254
Necrotizing fasciitis is a rare soft tissue infection and a life-threatening emergency, often fatal. Its incidence and management are described plentifully in the medical literature regarding the most common anatomical sites involved like the abdomen, lower and upper limbs, and perineum. However, available data and case reports of chest wall necrotizing fasciitis after thoracic procedures are scarce, mainly after major cardiac operations. We report and discuss a case of necrotizing fasciitis of the chest wall occurring in the immediate postoperative period of a cardiac procedure, and include a brief review of the concepts, pathophysiology, and treatment reported in the medical literature. We emphasize the need for early diagnosis and urgent and effective surgical debridement. Of importance is the fact that we have not found any references in the literature to cases similar or equal to the one we describe here, which occurred in the postoperative period of a cardiac procedure. 相似文献
4.
Myrna Maria Arcanjo Frota Barros Maria Imaculada De Queiroz Rodrigues Francisco Wilker Mustafa Gomes Muniz Lidiany Karla Azevedo Rodrigues 《Clinical oral investigations》2020,24(2):521-532
This study aimed to systematically review the literature regarding the risk of selective removal—in comparison with stepwise and nonselective removal 相似文献
5.
6.
Frota Filho JD Lucchese FA Leães P Valente LA Vieira MS Blacher C 《Arquivos brasileiros de cardiologia》2002,78(6):586-591
Cardiac angiosarcomas are malignant tumors that almost invariably have a short and fatal evolution. The therapeutic approach includes surgery, chemotherapy, and radiation therapy, alone or in combination. Heart transplantation is an attractive option in nonresectable tumors, even though the current experience is still limited. However, in most patients, the diagnosis is still established late, and survival is only slightly altered by the proposed treatments, mainly due to previously existing and undetected metastases. We report a case that illustrates the therapeutic dilemma faced with this neoplasia, and we discuss the case based on a literature review. 相似文献
7.
Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural,Neurochemical and Transcriptional Alterations 下载免费PDF全文
Ricardo Basto Souza Annyta Fernandes Frota Rayane Siqueira Sousa Nayara Araújo Cezario Tarcizio Brito Santos Luziana Mara Frota Souza Chistiane Oliveira Coura Valdécio Silvano Monteiro Gerardo Cristino Filho Silvânia Maria Mendes Vasconcelos Rodrigo Maranguape Silva da Cunha Lissiana Magna Vasconcelos Aguiar Norma Maria Barros Benevides 《Basic & clinical pharmacology & toxicology》2017,120(2):159-170
8.
Marcelo Carvalho Vieira Fernanda de Souza Nogueira Sardinha Mendes Flavia Mazzoli-Rocha Rudson Santos Silva Aline Maria Nunes Viana Aline Xavier Frota Gilberto Marcelo Sperandio da Silva Paula Simplício da Silva Alejandro Marcel Hasslocher-Moreno Roberto Magalhães Saraiva Andrea Silvestre de Sousa Mauro Felippe Felix Mediano 《Tropical medicine & international health : TM & IH》2021,26(3):355-365
9.
Mendonça JE Vilela MC Bittencourt H Lapa RM Oliveira FG Alessio ML Guedes RC De Oliveira Costa MS Da Costa BL 《Nutritional neuroscience》2004,7(4):223-234
The aim of the present study was investigate, in young rats, the effects of malnutrition on astrocyte distribution of two hypothalamic regions, the circadian pacemaker suprachiasmatic nucleus (SCN) and the medial preoptic area (MPA). Control rats were born from mothers fed on commercial diet since gestation and malnourished rats from mothers fed on multideficient diet, from the beginning of gestation (GLA group) or from the onset of lactation (LA group). After weaning, pups received ad libitum the same diet as their mothers, and were maintained under a 12/12 h light/dark cycle. The animals were analyzed either at 30-33, or 60-63 days of life. Brain coronal sections (50 microm) were processed to visualize glial fibrillary acidic protein (GFAP) immunoreactivity. Compared to control rats, both malnourished groups of 30 and 60 days exhibited a reduced number of GFAP-immunoreactive astrocytes in the SCN. The total GFAP-immunoreactive area in the SCN of the GLA group differed from the control group at both age ranges analyzed. The GFAP expression as measured by the relative optical density (ROD) exhibited a 50-60% reduction in the MPA in both malnourished groups, compared to controls. The results suggest that malnutrition early in life leads to alterations in gliogenesis or glial cell proliferation in both nuclei, being these alterations greater in the MPA. Compensatory plasticity mechanisms in the GFAP-expression seem to be developed in the astrocyte differentiation process in the SCN, especially when the malnutrition is installed from the lactation. 相似文献
10.
Kompalic-Cristo A Nogueira SA Guedes AL Frota C González LF Brandão A Amendoeira MR Britto C Fernandes O 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2004,98(2):92-95
The polymerase chain reaction amplification of a fragment of the B1 gene of Toxoplasma gondii coupled to hybridization was performed in 42 patients from Rio de Janeiro, Brazil. The results showed 50% of positivity in the IgM positive toxoplasmosis group, and 12.5% in the positive IgG and negative IgM individuals. The data presented here revealed a lack of specificity of the molecular approach, clearly indicating that the primers used may co-amplify human sequences. 相似文献