全文获取类型
收费全文 | 483篇 |
免费 | 18篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 92篇 |
口腔科学 | 5篇 |
临床医学 | 55篇 |
内科学 | 83篇 |
皮肤病学 | 17篇 |
神经病学 | 14篇 |
特种医学 | 97篇 |
外科学 | 47篇 |
综合类 | 7篇 |
预防医学 | 19篇 |
眼科学 | 7篇 |
药学 | 37篇 |
肿瘤学 | 8篇 |
出版年
2019年 | 6篇 |
2017年 | 6篇 |
2015年 | 3篇 |
2014年 | 9篇 |
2013年 | 6篇 |
2012年 | 6篇 |
2011年 | 5篇 |
2010年 | 21篇 |
2009年 | 11篇 |
2008年 | 13篇 |
2007年 | 17篇 |
2006年 | 15篇 |
2005年 | 13篇 |
2004年 | 11篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 7篇 |
2000年 | 7篇 |
1999年 | 3篇 |
1998年 | 18篇 |
1997年 | 21篇 |
1996年 | 15篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 13篇 |
1992年 | 4篇 |
1991年 | 17篇 |
1990年 | 19篇 |
1989年 | 23篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 19篇 |
1985年 | 19篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1975年 | 11篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有509条查询结果,搜索用时 15 毫秒
1.
N F Druik S P Galich V M Seliuk A V Reznikov A I Zimenko 《Ortopediia travmatologiia i protezirovanie》1990,(12):27-32
The authors have thoroughly studied the versions of anatomic structure, peculiarities of blood circulation and innervation of lateral arm graft at 20 recent cadavers. The graft can be utilized in different modifications; cutaneofascial, subcutaneofascial, musculocutaneous, osteocutaneous. In the clinic were made 8 free microsurgic transplantations of lateral arm graft for plasty of tissues of different genesis in functionally important zones of hand and foot. In long-term post-operative period all patients demonstrated good functional and cosmetic results. 相似文献
2.
ALBERTO Q FARIAS LUCIANA L GONÇALVES EDUARDO LR CANÇADO ANTONIO C SEGURO SILVIA B CAMPOS CLARICE P ABRANTES-LEMOS FLAIR J CARRILHO 《Journal of gastroenterology and hepatology》2006,20(1):147-152
Background and Aims: Primary biliary cirrhosis (PBC) might be complicated by osteoporosis, whose etiology remains unknown but seems to be multifactorial. Prevalence rates of 30% to 60% for distal renal tubular acidosis (DRTA) have been reported in PBC patients, generally as incomplete DRTA. Although it is undisputed that a reduced bone mineral density (BMD) is the expected outcome among patients who have been suffering from longstanding chronic metabolic acidosis, it is unclear if incomplete DRTA is also associated with metabolic bone disease in PBC patients. The present study was undertaken to compare the BMD of PBC patients with and without DRTA.
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
3.
Iu V Sergeev Iu P Reznikov E V Lobanova N S Pimenova 《Vestnik dermatologii i venerologii》1989,(4):4-7
Eighty-eight patients with atopic dermatitis have been examined for the complementary proteins C3 (C3c), C3act., C4, C1inact. by radial immunodiffusion; in 36 of these patients anaphylatoxins C3a des Arg, C5a des Arg, and C4a des Arg have been radioimmunoassayed. Increased levels of C4a des Arg have been revealed in 50% of the examinees. C3a des Arg levels did not differ significantly from the reference values, and C5a des Arg level has been within the normal range in all the patients. C4a des Arg has been related to the severity of the skin inflammation and did not depend on the serum IgE content. C3 (C3c), C3act., C1inact. have been elevated and C4 reduced. These findings evidence activation of the complementary system in atopic dermatitis and indicate the role of anaphylatoxin C4a des Arg in the maintenance of the inflammatory reactions. 相似文献
4.
5.
6.
The effect of prolonged administration of antiandrogen flutamide (FT) on testosterone (T) metabolism in the prostate (P) of intact and castrated rats and animals receiving androgens with substitution purpose was studied. In intact animals the production of dehydrotestosterone from labeled T in vitro was decreased in 30 days by 50%. The influence of FT on 5 alpha-reductase was shown to be determined by the blockade of androgenic effects. Proceeding from the results of experiments with FT and its hydroxylated metabolite added to incubated homogenates of the prostate of intact animals it was assumed that FT hydroxylated metabolite mediated FT influence on T metabolism. 相似文献
7.
Prior studies have shown that pneumothorax is one of the more difficult entities to diagnose with digitized radiography. This study was designed to test whether increasing resolution from 1.25 to 2.5 line pairs per millimeter (lp/mm) and image processing (edge enhancement from unsharp masking) would increase accuracy and confidence in the diagnosis of pneumothorax, as well as normal cases and other forms of lung disease. Conventional radiographs were digitized with use of a laser reader and then reformatted as film hard copy. Eleven observers read 35 cases reformatted in three different ways (1.25 lp/mm, 2.5 lp/mm, 1.25 lp/mm unsharp mask). The images with finer resolution (2.5 lp/mm) and unsharp mask images were superior to those with coarser resolution (1.25 lp/mm) for the diagnosis of pneumothorax. There was no difference in diagnostic accuracy for normal patients. For abnormalities other than pneumothorax, the unsharp mask images were significantly worse. Confidence in the diagnosis of pneumothorax and other abnormalities was highest with the finest resolution (2.5 lp/mm). 相似文献
8.
9.
Russian State Medical University, Moscow. Translated from Meditsinskaya Tekhnika, No. 6, pp. 43–44, November–December, 1992. 相似文献
10.
MGC Hendriks P Dogterom JT Ebels B Oosterhuis LR Geertsema T Hulot G Bianchetti and JHG Jonkman 《Fundamental & clinical pharmacology》1998,12(5):559-565
Summary— In the present study we have compared the steady state biopharmaceutic characteristics of four diltiazem once daily controlled release capsules: Mono-Tildiem LP 300® (300 mg), Adizem® XL (300 mg)1, Cardizem® (300 mg) and Dilacor® (240 mg). Sixteen healthy male volunteers (aged 22.9 ± 3.3 years, range 19–31 years) completed an open label, multiple oral dose, randomized, four-period crossover study without a washout period in between. The volunteers received each diltiazem formulation once daily for four days. Trough diltiazem and metabolites plasma concentrations were determined on days 3 and 4. The 24-h plasma concentration-time profiles were assessed after the dose on day 4 of each period. The following steady state pharmacokinetic parameters for diltiazem were calculated: the minimum plasma concentration (cmin), the maximum plasma concentration (cmax), the time to reach that concentration (tmax), the time interval during which the plasma concentration exceeds 50% of cmax (t50), the area under the plasma concentration-time curve (AUC72–96) and the peak-to-trough fluctuation (PTF). For the metabolites of diltiazem, N-mono-desmethyl-diltiazem (NDM) and desacetyldiltiazem (DAD), AUC72–96 (AUCNDM and AUCDAD) and the ratio metabolite/parent compound were calculated. Steady state was achieved on day 3. Except one, all controlled release formulations have satisfactory controlled release properties allowing once daily administration. However, significant (P < 0.05) differences were found between the pharmacokinetic characteristics which do not allow exchange of the various formulations. Concentrations well below 50 ng·mL-1 in the morning hours were observed for Dilacor® (240 mg) and Adizem® XL (300 mg), which could be a disadvantage of these formulations as it is well-known that ischaemic events occur at a higher rate during that part of the day. The plasma concentration profiles of NDM and DAD, the major circulating metabolites, parallel the plasma concentration profiles for the parent compound. From a clinical point of view, all treatments were well tolerated. 相似文献