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排序方式: 共有236条查询结果,搜索用时 15 毫秒
1.
Reinoud W. Brouwer Tijs S. C. Jakma Sita M. A. Bierma-Zeinstra Abida Z. Ginai Jan A. N. Verhaar 《Acta orthopaedica》2003,74(5):565-568
The whole leg radiograph (WLR), the standard technique for determining axial alignment, is usually taken in a standing position, although some prefer the supine position. To determine the difference between these two positions, we performed a standing and a supine WLR in 20 patients with a varus alignment. We found an average of 2 degrees more varus deviation in the standing position than in the supine position. 相似文献
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Kamp Tamara Brouwer Sandra Hylkema Tjerk H. van Beveren Jan Rijk Paul C. Brouwer Reinoud W. Stevens Martin 《Journal of occupational rehabilitation》2022,32(2):295-305
Journal of Occupational Rehabilitation - Purpose Both personal and work-related factors affect return to work (RTW) after total knee arthroplasty (TKA) and total hip arthroplasty (THA). Little is... 相似文献
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Ilse Gosens Liesbeth E.A.M. Mathijssen Bas G.H. Bokkers Hans Muijser 《Nanotoxicology》2014,8(6):643-653
There are many uncertainties regarding the hazard of nanosized particles compared to the bulk material of the parent chemical. Here, the authors assess the comparative hazard of two nanoscale (NM-211 and NM-212) and one microscale (NM-213) cerium oxide materials in 28-day inhalation toxicity studies in rats (according to Organisation for Economic Co-operation and Development technical guidelines). All three materials gave rise to a dose-dependent pulmonary inflammation and lung cell damage but without gross pathological changes immediately after exposure. Following NM-211 and NM-212 exposure, epithelial cell injury was observed in the recovery groups. There was no evidence of systemic inflammation or other haematological changes following exposure of any of the three particle types. The comparative hazard was quantified by application of the benchmark concentration approach. The relative toxicity was explored in terms of three exposure metrics. When exposure levels were expressed as mass concentration, nanosized NM-211 was the most potent material, whereas when expression levels were based on surface area concentration, micro-sized NM-213 material induced the greatest extent of pulmonary inflammation/damage. Particles were equipotent based on particle number concentrations. In conclusion, similar pulmonary toxicity profiles including inflammation are observed for all three materials with little quantitative differences. Systemic effects were virtually absent. There is little evidence for a dominant predicting exposure metric for the observed effects. 相似文献
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ABSTRACT: BACKGROUND: Socioeconomic inequalities in cardiovascular disease are pervasive, yet much remains to be understood about how they originate. The objective of this study was to explore the relations of socioeconomic status to lipid and glucose metabolism as indicators of cardiovascular health in 5-6 year olds. Additionally to explore the explanatory role of maternal factors, birth outcome, and child factors. METHODS: In 1308 5-6 year old ethnic Dutch children from the ABCD cohort study, lipids (cholesterol, LDL, HDL, triglycerides), glucose and C-peptide were measured after an overnight-fast. RESULTS: There were no differences in cholesterol, HDL, LDL, and triglycerides between socioeconomic groups, as indicated by maternal education and income adequacy. However, children of low educated mothers had on average a higher glucose (beta = 0.15; 95% confidence interval (CI) 0.03 - 0.27), logC-peptide (beta = 0.07; 95% CI 0.04 - 0.09), and calculated insulin resistance (HOMA-IR) (beta = 0.15; 95% CI 0.08 - 0.22) compared to children of high educated mothers. Only childhood BMI partly explained these differences (models controlled for age, height, and sex). CONCLUSIONS: The socioeconomic gradient in cardiovascular risk factors seems to emerge in early childhood. In absence of underlying mechanisms these empirical findings are relevant for public health care and further explanatory research. 相似文献
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Luthman J Hoebeek FE Maex R Davey N Adams R De Zeeuw CI Steuber V 《Cerebellum (London, England)》2011,10(4):667-682
Neurons in the cerebellar nuclei (CN) receive inhibitory inputs from Purkinje cells in the cerebellar cortex and provide the
major output from the cerebellum, but their computational function is not well understood. It has recently been shown that
the spike activity of Purkinje cells is more regular than previously assumed and that this regularity can affect motor behaviour.
We use a conductance-based model of a CN neuron to study the effect of the regularity of Purkinje cell spiking on CN neuron
activity. We find that increasing the irregularity of Purkinje cell activity accelerates the CN neuron spike rate and that
the mechanism of this recoding of input irregularity as output spike rate depends on the number of Purkinje cells converging
onto a CN neuron. For high convergence ratios, the irregularity induced spike rate acceleration depends on short-term depression
(STD) at the Purkinje cell synapses. At low convergence ratios, or for synchronised Purkinje cell input, the firing rate increase
is independent of STD. The transformation of input irregularity into output spike rate occurs in response to artificial input
spike trains as well as to spike trains recorded from Purkinje cells in tottering mice, which show highly irregular spiking
patterns. Our results suggest that STD may contribute to the accelerated CN spike rate in tottering mice and they raise the
possibility that the deficits in motor control in these mutants partly result as a pathological consequence of this natural
form of plasticity. 相似文献
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Nolan S. Hartkamp Reinoud P. H. Bokkers H. Bart van der Worp M. J. P. van Osch L. Jaap Kappelle Jeroen Hendrikse 《European radiology》2011,21(4):875-881