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排序方式: 共有76条查询结果,搜索用时 46 毫秒
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TAKADA AKIRA; TSUTSUMI MIKIHIRO; KOBAYASHI YUKI 《Alcohol and alcoholism (Oxford, Oxfordshire)》1994,29(6):719-727
Genetic factors related to the development of alcoholic liverand pancreatic diseases (ALD and APD) and of alcohol-inducedasthma were analyzed. The development of ALD is geneticallycontrolled and is directly associated with the polymorphismsof the genes of acetaldehyde (Ac-CHO) and ethanol-metabolizingenzymes, aldehyde dehydrogenase-2 (ALDH2) and cytochrome P4502E1.The development of ALD and APD may also be genetically linkedwith the induction of gamma-glutamyl transferase (GTT) by alcohol.Alcohol-induced asthma is related to the genotypes of ALDH2and is caused by rapid elevation of blood Ac-CHO. ALDH1 playsa very important role in the oxidation of Ac CHO in blood. 相似文献
3.
Koji WADA Mikako ARAKIDA Rika WATANABE Motomi NEGISHI Jun SATO Akizumi TSUTSUMI 《Industrial health》2013,51(5):482-489
We aimed to determine the economic impact of absenteeism and presenteeism from five
conditions potentially comorbid with depressive symptoms—back or neck disorders,
depression, anxiety, or emotional disorders, chronic headaches, stomach or bowel
disorders, and insomnia—among Japanese workers aged 18–59 yr. Participants from 19
workplaces anonymously completed Stanford Presenteeism Scale questionnaires. Participants
identified one primary health condition and determined the resultant performance loss
(0–100%) over the previous 4-wk period. We estimated the wage loss by gender, using 10-yr
age bands. A total of 6,777 participants undertook the study. Of these, we extracted the
data for those in the 18–59 yr age band who chose targeted primary health conditions
(males, 2,535; females 2,465). The primary health condition identified was back or neck
disorders. We found that wage loss due to presenteeism and absenteeism per 100 workers
across all 10-yr age bands was high for back or neck disorders. Wage loss per person was
relatively high among those identifying depression, anxiety, or emotional disorders. These
findings offer insight into developing strategies for workplace interventions on
increasing work performance. 相似文献
4.
5.
VALRIE ANDRIEU ISABELLE RADFORD-WEISS XAVIER TROUSSARD CATHERINE CHANE FRANOISE VALENSI MARTINE GUESNU ELIE HADDAD FRANK VIGUIER FRANOIS DREYFUS BRUNO VARET GEORGES FLANDRIN ELIZABETH MACINTYRE 《British journal of haematology》1996,92(4):855-865
The t(8;21) identifies a subgroup of acute myeloid leukaemia (AML) with a relatively good prognosis which may merit different treatment. It is associated predominantly, but not exclusively, with AML M2, and corresponds to rearrangements involving the AML1 and ETO genes. AML1-ETO positive, t(8;21) negative cases are well recognized but their incidence is unknown. In order to determine optimal prospective AML1-ETO RT-PCR screening strategies, we analysed 64 unselected AML M1 and M2 cases and correlated the results with other biological parameters. Molecular screening increased the overall detection rate from 8% to 14%. AML1-ETO was found in 3% (1/32) of AML M1 and 25% (8/32) of M2, including three patients without a classic t(8;21) but with chromosome 8 abnormalities. It was more common in younger patients. Correlation with morphology enabled development of a scoring system which detected all nine AML1-ETO-positive cases with a false positive rate of 7% (4/55). Although certain AML1-ETO-positive cases demonstrated characteristic immunological features (CD19 and CD34 expression, CD33 negativity), each of these markers was insufficiently specific to permit prediction in an individual case. We conclude that initial routine prospective molecular screening for AML1-ETO in all AMLs, combined with standardized morphological and immunological analysis, is desirable in order to produce improved prognostic stratification and to determine whether screening can ultimately be restricted to appropriate subgroups. 相似文献
6.
Akiomi INOUE Norito KAWAKAMI Teruichi SHIMOMITSU Akizumi TSUTSUMI Takashi HARATANI Toru YOSHIKAWA Akihito SHIMAZU Yuko ODAGIRI 《Industrial health》2014,52(6):535-540
This study was aimed to investigate the test-retest reliability and validity of a short
version of the New Brief Job Stress Questionnaire (New BJSQ) whose scales have one item
selected from a standard version. Based on the results from an anonymous web-based
questionnaire of occupational health staffs and personnel/labor staffs, we selected
higher-priority scales from the standard version. After selecting one item with highest
item-total correlation coefficient from each scale, a 23-item questionnaire was developed.
A nationally representative survey was administered to Japanese employees
(n=1,633) to examine test-retest reliability and
validity. Most scales (or items) showed modest but adequate levels of test-retest
reliability (r>0.50). Furthermore, job demands and job
resources scales (or items) were associated with mental and physical stress reactions
while job resources scales (or items) were also associated with positive outcomes. These
findings provided a piece of evidence that the short version of the New BJSQ is reliable
and valid. 相似文献
7.
Our current study investigated how workplace social capital (WSC) mediates and moderates
the associations between adverse work characteristics and psychological distress among
Japanese workers. We collected cross-sectional data
(N=9,350) from a baseline survey of an occupational Japanese
cohort study. We focused on individual WSC and considered job demands/control,
effort/reward, and two types (i.e., procedural and interactional) of organizational
justice as work-characteristic variables. We defined psychological distress as a score of
≥5 on the Kessler Psychological Distress Scale (K6 scale). Multivariate logistic
regression analyses predicted a binary variable of psychological distress by individual
WSC and adverse work characteristics, adjusting for individual-level covariates.
Individual WSC mediated the associations between adverse work characteristics and
psychological distress in almost all model specifications. Additionally, individual WSC
moderated the associations of psychological distress with high job demands, high effort,
and low interactional justice when we used a high WSC cutoff point. In contrast,
individual WSC did not moderate such interactions with low job control, reward, or
procedural justice. We concluded that individual WSC mediated the associations between
adverse work characteristics and psychological distress among Japanese workers while
selectively moderating their associations at high levels of WSC. 相似文献
8.
GUILLAUME CHABY MD VALÉRIE VISEUX MD ALBERT ADRIEN RAMELET MD OLIVIER GANRY MD PhD MD ANNE BILLET MD CATHERINE LOK MD PhD 《Dermatologic surgery》2006,32(4):512-519
BACKGROUND: Although certain risk factors for poor healing of leg ulcers have been identified, data concerning the characteristics of refractory ulcers have not been specifically studied in the literature. OBJECTIVE: To study the characteristics of refractory venous leg ulcers. METHODS: We retrospectively studied prognostic factors for healing in patients with refractory venous leg ulcers followed and treated in our dermatology department between January 1993 and January 2000. Each patient included in this study was compared with two patients matched for age and gender and presenting leg ulcers with normal healing, followed during the same period. RESULTS: Thirty-two of 571 patients with leg ulcers were included. The study population consisted of 20 females and 12 males with a mean age 73.5 years. The control population comprised 64 patients, 40 females and 24 males, with a mean age of 73 years. Univariate analysis demonstrated the negative prognostic impact of several previously identified factors (including surface area and history of the ulcer). In particular, multivariate analysis identified four main risk factors for refractory ulcer that are often associated in these patients: associated arterial disease, presence of post-thrombotic popliteal sequelae, recurrence of the ulcer, and disability. CONCLUSION: Four main risk factors that are often associated were identified, indicating the multifactorial nature of these refractory ulcers. 相似文献
9.
EMMANUEL NICOLAS MARION BESSADET VALÉRIE COLLADO PILAR CARRASCO VALÉRIE ROGERLEROI MARTINE HENNEQUIN 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2010,20(5):366-373
International Journal of Paediatric Dentistry 2010; 20: 366–373 Background. While dental anxiety is often correlated with prior negative dental experience, prevention of dental anxiety should in theory include early exposure to the dental setting. Objective. We set out to evaluate factors affecting dental fear in French children. Methods. Dental fear was evaluated using a visual analogue scale (DF‐VAS) in a group of 1303 French children (681 boys and 622 girls) aged 5–11 years (mean: 8.12 years, SD: 1.42 years). Indicators of caries and oral hygiene were evaluated on dental examination. Indicators of well‐being related to oral health, dental experience, and oral health education were collected via a structured interview. Results. Dental fear was scored low in 75.7% (DF‐VAS 0–3), moderate in 16.7% (DF‐VAS 4–6), and high in 7.6% (DF‐VAS 7–10). DF‐VAS decreased statistically with experience of a prior dental visit. Children who had at least one decayed tooth presented a higher level of dental fear than those with no decay, while children with fillings were significantly less anxious than those without previous dental care. Conclusions. This study shows that for children aged 5–12 years, prior experience of the dental setting can act as a positive component of dental fear. 相似文献
10.
ATSUYUKI KOHARA MASAMICHI OKADA RIE TSUTSUMI KAZUSHIGE OHNO MASAYASU TAKAHASHI MASAO SHIMIZU-SASAMATA JUN-ICHI SHISHIKURA HIROSHI INAMI SHUICHI SAKAMOTO TOKIO YAMAGUCHI 《The Journal of pharmacy and pharmacology》1998,50(7):795-801
The in-vitro pharmacological properties of (2,3-dioxo-7-(1H-imidazol-***1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)-acetic acid monohydrate, YM872, a novel and highly water-soluble α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-receptor antagonist were investigated. YM872 is highly water soluble (83 mg mL?1 in Britton-Robinson buffer) compared with 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX), 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) or 6-cyano-7-nitroquinoxa-line-2,3-dione (CNQX). YM872 potently inhibits [3H]AMPA binding with a Ki (apparent equilibrium dissociation constant) value of 0.096 ± 0.0024 μM. However, YM872 had very low affinity for other ionotropic glutamate receptors, as measured by competition with [3H]kainate (high-affinity kainate binding site, concentration resulting in half the maximum inhibition (IC50) = 4.6 ± 0.14 μm), [3H]glutamate (N-methyl-D-aspartate (NMDA) receptor glutamate binding site, IC50 > 100 μM) and [3H]glycine (NMDA receptor glycine-binding site, IC50 > 100 μM). YM872 competitively antagonized kainate-induced currents in Xenopus laevis oocytes which express rat AMPA receptors, with a pA2 value of 6.97 ± 0.01. In rat hippocampal primary cultures, YM872 blocked a 20-μM AMPA-induced increase of intracellular Ca2+ concentration with an IC50 value of 0.82 ± 0.031 μM, and blocked 300-μM kainate-induced neurotoxicity with an IC50 value of 1.02 μM. These results show that YM872 is a potent and highly water-soluble AMPA antagonist with great potential for treatment of neurodegenerative disorders such as stroke. 相似文献