Iliopsoas Abscess Due to Brenner Tumor Malignancy: A Case Report

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苏州科技城医院:科技与生态同步建设六部曲

苏州科技城医院坐落于苏州高新区太湖之滨,由苏州高新区政府投资新建,是一所集医疗、科研、康复、预防于一体的三级综合性公立医院。医院占地面积140亩,总建筑面积180000m~2,总投资额16亿,设计床位1200张。医院于2013年9月29日奠基,2014年12月28日主体封顶,2016年4月正式投入使用,比预定日期提前了将近1年!     

有机溶剂作业场所通风排毒设施常见问题及控制策略

有机溶剂是工业生产中常见的职业病危害因素,所致的各类急慢性中毒时有发生。有机溶剂挥发至空气中呈无色透明状态,了解其在作业场所的挥发和分布特点,选择合适的通风排毒设施对于有机溶剂危害控制至关重要。本文拟通过分析有机溶剂挥发、分布的影响因素,结合各类通风排毒设施存在的常见问题,重点介绍有代表性的有机溶剂作业场所的通风排毒控制策略。     

儿童可逆性后部脑病综合征的研究现状与进展

可逆性后部脑病综合征(PRES)是一组异质性疾病,需要结合临床及神经影像学共同诊断。其病因复杂,发病机制不甚明确,高血压和钙调神经蛋白抑制剂是公认的危险因素。但对于儿童来说,其本身的基础疾病可能对此症的发生起决定性作用。PRES的临床表现与病变位置有关,头颅磁共振成像是首选的检查。其治疗的关键是迅速诊断,如诊治不及时,部分患者将发生不可逆的神经系统损害而遗留后遗症,甚至导致死亡。     

Monitoring Hepatocyte Dysfunction and Biliary Complication After Liver Transplantation Using Quantitative Hepatobiliary Scintigraphy

The significance of hepatobiliary scintigraphy (HBS) for hepatic graft function assessment was established mostly on retrospective studies and was not widely recognized due to the lack of quantitative data and variation in accuracy. This prospective study was performed to investigate the effectiveness of quantitative HBS for assessing hepatocyte dysfunction and biliary complication in liver transplant recipients.In 57 recipients who had undergone orthotopic liver transplantation, a total of 67 dynamic ^99mTc-EHIDA scans were performed and quantitative parameters including the hepatocyte extraction fraction (HEF), time to maximum hepatic radioactivity (T_max), and time for peak activity to decrease by 50% (T_1/2) were calculated. The scintigraphic results based on the 3 parameters were compared against the final diagnosis. A ROC curve analysis was carried out to identify the cutoff value of T_max for diagnosis of biliary stricture. Correlation between the parameters of postoperative HBS and conventional biochemical liver function indices were also analyzed.Quantitative ^99mTc-EHIDA HBS had an overall sensitivity of 94.12% (16/17), specificity of 93.33% (42/45), and diagnostic accuracy of 93.55% (58/62) for detecting hepatocyte dysfunction and biliary complication in liver transplant recipients. The recommended cutoff value of T_max for diagnosis of post-transplant biliary stricture was set at 15.75 min with a sensitivity of 100.0% and a specificity of 94.0%. The scintigraphic parameters (HEF, T_max) were statistically significantly associated with the conventional liver function parameters.Quantitative ^99mTc-EHIDA HBS offers a noninvasive imaging modality with high sensitivity and specificity to diagnose hepatocyte dysfunction as well as distinguish between patients with or without biliary stricture following liver transplantation. Furthermore, HEF and T_max values obtained from dynamic HBS show good correlation with conventional liver function parameters.     

拜唐苹治疗Ⅱ型糖尿病的临床观察及研究进展

目的观察拜唐苹治疗Ⅱ糖尿病的临床效果。方法30例病人，通过口服拜唐苹治疗一个月和一年后，记录血浆葡萄糖和血红蛋白，根据比较了解拜唐苹降糖效果。结果拜唐苹使患者的空腹血糖下降10．19％，非空腹血糖下降17．44％，血红蛋白治疗前有16人控制差，治疗后无一人控制差。结论拜唐苹治疗Ⅱ型糖尿病中空腹血糖轻中度增高，餐后血糖增高显著的病例，效果满意，副作用少。     

Pick’s disease with Pick bodies combined with progressive supranuclear palsy without tuft‐shaped astrocytes: A clinical,neuroradiologic and pathological study of an autopsied case

We report clinical, neuroradiologic features, and neuropathologic findings of a 76‐year‐old man with coexistent Pick’s disease and progressive supranuclear palsy. The patient presented with loss of recent memory, abnormal behavior and change in personality at the age of 60. The symptoms were progressive. Three years later, repetitive or compulsive behavior became prominent. About 9 years after onset, he had difficulty moving and became bed‐ridden because of a fracture of his left leg. His condition gradually deteriorated and he developed mutism and became vegetative. The patient died from pneumonia 16 years after the onset of symptoms. Serial MRI scans showed progressive cortex atrophy, especially in the bilateral frontal and temporal lobes. Macroscopic inspection showed severe atrophy of the whole brain, including cerebrum, brainstem and cerebellum. Microscopic observations showed extensive superficial spongiosis and severe neuronal loss with gliosis in the second and third cortical layers in the frontal, temporal and parietal cortex. There were Pick cells and argyrophilic Pick bodies, which were tau‐ and ubiquitin‐positive in neurons of layers II–III of the above‐mentioned cortex. Numerous argyrophilic Pick bodies were observed in the hippocampus, especially in the dentate fascia. In addition, moderate to severe loss of neurons was found with gliosis and a lot of Gallyas/tau‐positive globus neurofibrillary tangles in the caudate nucleus, globus pallidus, thalamus, substantia nigra, locus coeruleus and dentate nucleus. Numerous thorned‐astrocytes and coiled bodies but no‐tuft shaped astrocytes were noted in the basal ganglion, brainstem and cerebellar white matter. In conclusion, these histopathological features were compatible with classical Pick’s disease and coexistence with progressive supranuclear palsy without tuft‐shaped astrocytes.