全文获取类型
收费全文 | 2056篇 |
免费 | 188篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 64篇 |
妇产科学 | 35篇 |
基础医学 | 222篇 |
口腔科学 | 67篇 |
临床医学 | 309篇 |
内科学 | 387篇 |
皮肤病学 | 11篇 |
神经病学 | 109篇 |
特种医学 | 204篇 |
外科学 | 309篇 |
综合类 | 47篇 |
预防医学 | 171篇 |
眼科学 | 16篇 |
药学 | 121篇 |
中国医学 | 2篇 |
肿瘤学 | 132篇 |
出版年
2021年 | 30篇 |
2019年 | 18篇 |
2018年 | 18篇 |
2017年 | 17篇 |
2016年 | 27篇 |
2015年 | 28篇 |
2014年 | 28篇 |
2013年 | 57篇 |
2012年 | 72篇 |
2011年 | 77篇 |
2010年 | 55篇 |
2009年 | 72篇 |
2008年 | 60篇 |
2007年 | 73篇 |
2006年 | 75篇 |
2005年 | 69篇 |
2004年 | 65篇 |
2003年 | 69篇 |
2002年 | 53篇 |
2001年 | 56篇 |
2000年 | 81篇 |
1999年 | 51篇 |
1998年 | 59篇 |
1997年 | 49篇 |
1996年 | 46篇 |
1995年 | 52篇 |
1994年 | 42篇 |
1993年 | 34篇 |
1992年 | 52篇 |
1991年 | 37篇 |
1990年 | 41篇 |
1989年 | 54篇 |
1988年 | 54篇 |
1987年 | 47篇 |
1986年 | 42篇 |
1985年 | 42篇 |
1984年 | 32篇 |
1983年 | 29篇 |
1982年 | 32篇 |
1981年 | 28篇 |
1980年 | 25篇 |
1979年 | 23篇 |
1978年 | 28篇 |
1977年 | 26篇 |
1976年 | 33篇 |
1975年 | 16篇 |
1974年 | 19篇 |
1973年 | 19篇 |
1970年 | 15篇 |
1969年 | 16篇 |
排序方式: 共有2264条查询结果,搜索用时 15 毫秒
1.
Philip A. Rozario Nancy L. Morrow-Howell Enola K. Proctor 《Quality of life research》2006,15(4):755-759
Using the SF-12 to measure physical and mental functioning, the authors examine the intra-individual changes in health-related
quality of life (HRQOL) 6 months post-discharge for depressed older adults. In addition, they examine three sets of predictors
that might influence these changes. The sample of depressed older adults was recruited from an inpatient geropsychiatry unit.
Although their physical and mental health scores on the SF-12 were lower than comparable norms, the sample showed an average
increase in their mental functioning but a decrease in the physical functioning over the 6 months. Negative life-events were
significant predictors of people who reported no change in their mental health functioning and decreases in their physical
health functioning. Interestingly, those who experienced positive life events were more likely to report declines and younger
participants were more likely to report no change in their physical functioning. The findings indicate that the effects of
depression on HRQOL can have enduring effects on a sample of previously hospitalized older adults. The significance of life
event changes might signify the importance of taking into account non-traditional areas of medical interventions. Further,
the findings indicate the usefulness of the SF-12 quantifying HRQOL outcomes. 相似文献
2.
Alex N. Bullock Julia Henckel Brian S. DeDecker Christopher M. Johnson Penka V. Nikolova Mark R. Proctor David P. Lane Alan R. Fersht 《Proceedings of the National Academy of Sciences of the United States of America》1997,94(26):14338-14342
Some 50% of human cancers are associated with mutations in the core domain of the tumor suppressor p53. Many mutations are thought just to destabilize the protein. To assess this and the possibility of rescue, we have set up a system to analyze the stability of the core domain and its mutants. The use of differential scanning calorimetry or spectroscopy to measure its melting temperature leads to irreversible denaturation and aggregation and so is useful as only a qualitative guide to stability. There are excellent two-state denaturation curves on the addition of urea that may be analyzed quantitatively. One Zn2+ ion remains tightly bound in the holo-form of p53 throughout the denaturation curve. The stability of wild type is 6.0 kcal (1 kcal = 4.18 kJ)/mol at 25°C and 9.8 kcal/mol at 10°C. The oncogenic mutants R175H, C242S, R248Q, R249S, and R273H are destabilized by 3.0, 2.9, 1.9, 1.9, and 0.4 kcal/mol, respectively. Under certain denaturing conditions, the wild-type domain forms an aggregate that is relatively highly fluorescent at 340 nm on excitation at 280 nm. The destabilized mutants give this fluorescence under milder denaturation conditions. 相似文献
3.
4.
Coronary artery bypass grafts: visualization with MR imaging 总被引:1,自引:0,他引:1
5.
Diane Lee Proctor 《Children's Health Care》1987,16(1):13-17
The purpose of this study was to examine the levels of anxiety of mothers with children in pediatric intensive care units with different types of visitation policies, both structured and individualized Forty subjects were obtained from two children's hospitals A comparative research design was used Data showed that mothers who experienced individualized visitation had significantly lower anxiety scores (p < 005) than mothers who experienced structured visitation Findings also revealed that mothers viewed their child's illness as less severe when individualized visitation was permitted as opposed to structured visitation. 相似文献
6.
表小檗碱对α受体的作用 总被引:2,自引:0,他引:2
表小檗碱(epiberberine,EB)是从湖北产黄连(Coptis chinensis Franch)中提取的一种生物碱,属苯喹嗪类原小檗碱,对其药理作用的研究资料甚少,未见其对α肾上腺素体作用的报道。资料表明,许多原小檗碱类化合物有α受体阻滞作用,为从该类化合物中选择 相似文献
7.
8.
The purpose of this pilot study was to observe both relaxed and deep breathing patterns in a convenience sample to determine the incidence of normal versus faulty patterns of respiration. These observations were then combined with respondent answers to a survey on pain history to determine if there is any correlation between faulty breathing and musculo-skeletal pain patterns. If such a correlation can be made, then we propose that clinicians working with chronic pain patients may have improved outcomes if they address and correct faulty breathing patterns. Based on this study, it is suggested to include the evaluation and treatment of faulty respiration in the rehabilitation of chronic musculo-skeletal conditions, most notably cervical pain. 相似文献
9.
Risk of spinal cord dysfunction in patients undergoing thoracoabdominal aortic replacement. 总被引:1,自引:0,他引:1
L H Hollier S R Money T C Naslund C D Proctor W C Buhrman R J Marino D E Harmon F J Kazmier 《American journal of surgery》1992,164(3):210-3; discussion 213-4
The records of 150 consecutive patients undergoing thoracoabdominal aortic replacement from 1980 to 1991 were retrospectively reviewed. There were 89 men and 61 women; mean age was 67.8 years (range: 33 to 88 years). Since June 1989, a multimodality prospective perioperative protocol was used to reduce the risk of spinal cord dysfunction. Ischemia is minimized by complete intercostal reimplantation whenever possible, cerebrospinal fluid drainage, and maintenance of proximal hypertension during cross-clamping. Spinal cord metabolism is reduced by moderate hypothermia, high-dose barbiturates, and avoidance of hyperglycemia. Reperfusion injury is minimized by the use of mannitol, steroids, and calcium channel blockers. Ninety-seven percent of patients survived long enough for evaluation of their neurologic function. Spinal cord dysfunction was reduced from 6 of 108 (6%) in the preprotocol group to 0 of 42 in the protocol group (0%) (p less than 0.01). The overall 30-day operative mortality was not significantly different between the groups (9% versus 12%, p = NS). A multimodality protocol appears to be effective in reducing the risk of spinal cord injury during thoracoabdominal aortic replacement. 相似文献
10.
Over recent years, Bradford has had a consistently high perinatal mortality rate (PNMR), especially amongst its Asian population, 66% of whom originate from Pakistan. There is a high incidence of consanguineous marriages reported among Pakistani and Muslim couples. Often, this observation is used to explain their higher PNMR and congenital malformation rates. The factors affecting birth outcome in Pakistani women are complex and interrelated. Socioeconomic, genetic, biological and environmental factors all contribute to adverse birth outcome. In addition, these are complicated by discrimination, communication barriers and culture blaming. The aim of this paper is to challenge midwives and other health professionals to reconsider the overwhelming emphasis placed on consanguinity as a factor affecting birth outcome, and to recognise the impact and interplay of other confounding variables. 相似文献