Dermaprotecting properties of sodium succinate under conditions of impaired circulation

Sodium succinate improves the survival of a skin graft in mice, rats, and dogs normalizes histamine and serotonin concentrations in the epidermis and blood, exhibits antitoxic activity, improves microcirculation in the skin, brain, heart, kidneys, and testes without any appreciable effect on systemic arterial pressure, cardiac function, and liver blood flow in rats. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 420–424, October, 1998     

Use of flexible intramedullary nailing in combination with an external fixator for a postoperative defect and pseudarthrosis of femur in a girl with osteogenesis imperfecta type VIII: a case report

Telescopic rodding has been developed in order to obtain long-lasting osteosynthesis in the growing long bones of children with osteogenesis imperfecta (OI). The major and still unsolved drawback of any telescopic rod or nail design is a lack of rotational stability and, currently, no telescopic system allows immediate weight-bearing. When these problems are associated with insufficient longitudinal bone stability and diminished healing capacity, the result can be unfavourable causing secondary bone fragment displacement, delayed or non-union. This article presents a case report of operative treatment in a 9-year-old girl affected with OI type VIII complicated with postoperative defect and pseudarthrosis of the femur causing functional impairment with loss of walking ability. A combination of intramedullary flexible nailing and minimal external fixation was applied for treatment of femoral defect-pseudarthrosis in a girl of 9 years with OI type VIII. Intramedullary and extramedullary nails with wrapping of titanium nickel mesh subperiosteally provided osteosynthesis and deformity correction of the tibia of a small intramedullary canal diameter. Upright standing and walking with progressive weight-bearing was started 4 days after surgery. There were no septic or vascular complications nor complications related to Ilizarov fixator. Radiographs demonstrated bone union in the femur 46 days after surgery. At the follow-up visit 9 months after fixator removal, clinical alignment remained excellent without any relapse of deformity. Bone remodelling with restitution of medullary canal was noted on lower limb radiographs. The patient was able to stand and walk without pain with an aide or walker. At the follow-up visit 17 months after fixator removal, there was no decrease in achieved functional abilities and the treatment outcome remained satisfactory. Use of an external fixator with intramedullary nailing for treatment of postoperative pseudarthrosis in patient with severe OI (recessive form of OI, type VIII) provides longitudinal, rotational and angular stability. Furthermore, this approach ensured early functional activity and walking with full weight-bearing, both favourable conditions for bone tissue regeneration. The external fixator was applied for a short period and only for additional stability and not for progressive deformity correction or other manipulation. In addition, the combination of intramedullary and extramedullary nailing and subperiosteal titanium nickel mesh seems to be promising for osteosynthesis in the deformity correction of bones with small diameter in children with OI.     

Synthesis and Pharmacokinetics of 2-(4-amino-3,5-dichlorophenyl)-2-(alkylamino)ethanols - Structural Isomers of β2 Agonists Clenproperol and Clenpenterol

Pharmaceutical Chemistry Journal - Methods for the synthesis of 2-(4-amino-3,5-dichlorophenyl)-2-(isopropylamino)ethanol and 2-(4-amino-3,5-dichlorophenyl)-2-(tert-amylamino)ethanol, which are...     

Plasma x-ray radiation source

This paper gives the results of studies on a plasma x-ray source, which enables one to obtain a 2.5-krad radiation dose per pulse over an area of 100 cm2 in the quantum energy range from 20 to 500 keV. Pulse duration is 100 ns. Spectral radiation distributions from a diode under various operation conditions of a plasma are obtained. A Marx generator served as an initial energy source of 120 kJ with a discharge time of T/4 = 10-6 s. A short electromagnetic pulse (10-7 s) was shaped using plasma erosion opening switches.     

Prospects of using hard dispersions in development of dosage forms for therapeutic and prophylactic use

Thermoanalytical, chromatographic, and microscopic methods of analysis were used for identification of hard dispersions (HD) and their differences from physical mixtures (PM) by benzene PEG-4000 model systems. A complex of physiocochemical methods showed that benzonal and PEG-4000 are not thermally destroyed during simultaneous melting at 140 degrees C. Differences in thermoanalytical characteristics of PM and HD, expressed in suppression of phase transition temperatures, changes in the type of melting peaks and heats, and in the absence of drug melting peak and heats in HD vs. PM confirm the formation of new physiochemical systems differing from PM. The resultant quantitative relationships between temperature depression and melting heats for HD and PM of different composition correlate with chromatographic findings.     

Synthesis and Local Anesthetic Activity of 1,2-Disubstituted Imidazo[1,2-a]benzimidazoles

Pharmaceutical Chemistry Journal -     

Citrate and Acetate Ions Determined in Blood Preservatives and Infusion Solutions by Ion-Exclusion Chromatography

Pharmaceutical Chemistry Journal -