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Kullaya Takkavatakarn Pongpratch Puapatanakul Jeerath Phannajit Warumphon Sukkumme Pajaree Chariyavilaskul Patita Sitticharoenchai Asada Leelahavanichkul Pisut Katavetin Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong 《Toxins》2021,13(10)
P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate on protein-bound uremic toxins in pre-dialysis CKD patients with hyperphosphatemia. Forty pre-dialysis CKD patients with persistent hyperphosphatemia were randomly assigned to receive either 2400 mg of sevelamer daily or 1500 mg of calcium carbonate daily for 24 weeks. A significant decrease of total serum p-cresyl sulfate was observed in sevelamer therapy compared to calcium carbonate therapy (mean difference between two groups −5.61 mg/L; 95% CI −11.01 to −0.27 mg/L; p = 0.04). There was no significant difference in serum indoxyl sulfate levels (p = 0.36). Sevelamer had effects in terms of lowering fibroblast growth factor 23 (p = 0.01) and low-density lipoprotein cholesterol levels (p = 0.04). Sevelamer showed benefits in terms of retarding CKD progression. Changes in vascular stiffness were not found in this study. 相似文献
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Virojanawat Mathurot Puapatanakul Pongpratch Chuengsaman Piyatida Boonyakrai Chanchana Buranaosot Sompon Katavetin Pisut Praditpornsilpa Kearkiat Eiam-Ong Somchai Kanjanabuch Talerngsak 《International urology and nephrology》2021,53(7):1463-1471
International Urology and Nephrology - Hypokalemia is highly prevalent in chronic peritoneal dialysis (PD) patients worldwide, particularly in Thailand. This study aims to investigate the major... 相似文献
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Talerngsak Kanjanabuch Suramath Isaranuwatchai Tanawin Nopsopon Theerachai Thammathiwat Thitipong Pooprasert Pongpratch Puapatanakul Krit Pongpirul Ratana Chawanasuntorapoj Piyawan Kittiskulnam Somchai Eiam-Ong Kring Tungsanga Saowaluck Chusil Vuddhidej Ophascharoensuk Supat Vanichakarn Visith Sitprija Vijitr Boonpucknavig the Nephrology Society of Thailand 《Nephrology (Carlton, Vic.)》2023,28(Z1):24-34
Background
This study aims to investigate the influence of different kidney biopsy practices on the prevalence of glomerular pathologic patterns in the largest kidney biopsy registry in Thailand.Methods
We conducted a retrospective review of kidney biopsy records from the period between 2000 and 2014. The records were obtained from 2 major institutions: King Chulalongkorn Memorial Hospital, a large university-based hospital, and the Kidney Center Bangkok Hospital, which provides pathology services to hospitals throughout Thailand. The study included native kidney biopsies from all provinces in Thailand, excluding paediatric patients, kidney transplant recipients, and cases of inadequate and repeated biopsies. Patient demographics, indications for biopsy, and final glomerular diagnoses were compared across different hospital practice settings: university (UVH), private (PVH) and public (PBH).Results
A total of 5893 eligible native kidney biopsies were identified from a pool of 7005 biopsies conducted over a 15-year period in 25 provinces throughout Thailand. The 3 most common indications for biopsy were suspected kidney involvement in systemic lupus erythematosus (SLE) (29%), nephrotic syndrome (NS) (29%), and acute glomerulonephritis (AGN)/rapidly progressive glomerulonephritis (RPGN) (13%). The leading indication for biopsy differed across practice types, with suspected kidney involvement in SLE being the primary indication in UVH, while NS took precedence in both PBH and PVH practices. Notably, UVH performed fewer kidney biopsies for asymptomatic urinary abnormalities and diabetes-related indications compared with PVH and PBH. The leading glomerular diagnoses correlated with the biopsy indications, with lupus nephritis (LN) being the most common diagnosis in UVH and PBH practices, whiles immunoglobulin A nephropathy was the predominant diagnosis in PVH practice.Conclusion
Hospital practice types significantly impact the prevalence of glomerular pathologic diagnosis patterns in kidney biopsy data, highlighting the importance of considering this influence in epidemiological comparisons. 相似文献5.
Guttiga Halue Huttaporn Tharapanich Jeerath Phannajit Talerngsak Kanjanabuch Athiphat Banjongjit Pichet Lorvinitnun Suchai Sritippayawan Wichai Sopassathit Ussanee Poonvivatchaikarn Somphon Buranaosot Wanida Somboonsilp Pimpong Wongtrakul Chanchana Boonyakrai Surapong Narenpitak Sajja Tatiyanupanwong Wadsamon Saikong Sriphrae Uppamai Setthapon Panyatong Rutchanee Chieochanthanakij Niwat Lounseng Angsuwarin Wongpiang Worapot Treamtrakanpon Peerapach Rattanasoonton Narumon Lukrat Phichit Songviriyavithaya Uraiwan Parinyasiri Piyarat Rojsanga Patnarin Kanjanabuch Pongpratch Puapatanakul Krit Pongpirul David W. Johnson Jeffrey Perl Roberto Pecoits-Filho Vuddhidej Ophascharoensuk Kriang Tungsanga Thailand PDOPPS Steering Committee 《Nephrology (Carlton, Vic.)》2023,28(Z1):35-47
Background
Patient-reported outcome measures (PROMs) are widely recognized as valuable predictors of clinical outcomes in peritoneal dialysis (PD). Our study aimed to explore the connections between patient-reported constipation and clinical outcomes.Methods
We assessed constipation in patients across 22 facilities participating in the Thailand Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014 to 2017. Constipation diagnosis utilized objective assessment tools such as the Bristol stool form scale (BSFS) and a self-reported questionnaire known as the constipation severity score (CSS). The BSFS is a 7-level scale that visually inspects feces based on texture and morphology, while the CSS measures constipation duration and severity using a 5-point Likert scale for various factors. We employed Cox proportional hazards model regression to determine the associations between constipation and clinical outcomes, including mortality, hemodialysis (HD) transfer and peritonitis.Results
Among 975 randomly selected PD patients from 22 facilities, 845 provided written informed consent, and 729 completed CSS questionnaire. Constipation was prevalent in the PD population (13%), particularly among older patients, those who were caregiver dependent, had diabetes and poorer nutritional status (indicated by lower time-averaged serum albumin, potassium, creatinine and phosphate concentrations). Twenty-seven percent of which experiencing symptoms of constipation for over a year. Notably, self-reported constipation at baseline was significantly associated with a shorter time to first peritonitis and higher rates of peritonitis and death. However, no significant association was found between constipation and HD transfer after adjusting for various factors, including age, gender, PD vintage, comorbidities, shared frailty by study sites and serum albumin.Conclusion
Patient-reported constipation independently correlated with increased risks of peritonitis and all-cause mortality, though no such correlation was observed with HD transfer. These findings underscore the need for further investigation to identify effective interventions for constipation in PD patients. 相似文献
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