全文获取类型
收费全文 | 1138篇 |
免费 | 88篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 59篇 |
妇产科学 | 12篇 |
基础医学 | 98篇 |
口腔科学 | 31篇 |
临床医学 | 180篇 |
内科学 | 232篇 |
皮肤病学 | 14篇 |
神经病学 | 47篇 |
特种医学 | 243篇 |
外科学 | 166篇 |
综合类 | 21篇 |
预防医学 | 36篇 |
眼科学 | 7篇 |
药学 | 41篇 |
中国医学 | 5篇 |
肿瘤学 | 38篇 |
出版年
2024年 | 3篇 |
2023年 | 9篇 |
2021年 | 9篇 |
2020年 | 8篇 |
2019年 | 8篇 |
2018年 | 25篇 |
2017年 | 14篇 |
2016年 | 23篇 |
2015年 | 30篇 |
2014年 | 35篇 |
2013年 | 27篇 |
2012年 | 29篇 |
2011年 | 33篇 |
2010年 | 45篇 |
2009年 | 64篇 |
2008年 | 43篇 |
2007年 | 28篇 |
2006年 | 31篇 |
2005年 | 18篇 |
2004年 | 15篇 |
2003年 | 22篇 |
2002年 | 18篇 |
2001年 | 19篇 |
2000年 | 20篇 |
1999年 | 19篇 |
1998年 | 50篇 |
1997年 | 56篇 |
1996年 | 64篇 |
1995年 | 48篇 |
1994年 | 44篇 |
1993年 | 48篇 |
1992年 | 14篇 |
1991年 | 7篇 |
1990年 | 15篇 |
1989年 | 38篇 |
1988年 | 31篇 |
1987年 | 34篇 |
1986年 | 33篇 |
1985年 | 24篇 |
1984年 | 15篇 |
1983年 | 9篇 |
1982年 | 22篇 |
1981年 | 14篇 |
1980年 | 9篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 12篇 |
1976年 | 11篇 |
1975年 | 14篇 |
1937年 | 3篇 |
排序方式: 共有1233条查询结果,搜索用时 0 毫秒
1.
ME BURGE AM JOSHUA CM McNEIL R HUI MJ BOYER R ABRAHAM 《Asia-Pacific Journal of Clinical Oncology》2005,1(1):47-52
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma. 相似文献
2.
3.
4.
5.
6.
7.
8.
9.
10.
AE Castellano G Micieli P Bellantonio MG Buzzi S Marcheselli F Pompeo F Rossi G Nappi 《Cephalalgia : an international journal of headache》1998,18(9):622-630
Intracerebral vascular reactivity induced by the nitric oxide (NO) donor isosorbide dinitrate (IDN, 5 mg sublingually) is more major and longer-lasting in migraine patients who develop delayed headache in response to the drug. The headache is purportedly due to neuronally-mediated vascular mechanisms. Indomethacin inhibits prostaglandin synthesis, which is involved in NO generation. Indomethacin also decreases cerebral blood flow by constricting precapillary resistance vessels. In the present study, the hemodynamic effects of indomethacin were evaluated in migraine patients and healthy controls by means of transcranial Doppler monitoring. Indomethacin caused a significant decrease in mean flow velocity in the middle cerebral artery. This was an additional effect to the mean velocity decrease induced by IDN. The interactions between the two drugs suggest that their effects on cerebral hemodynamics (and pain) may be of relevance both in understanding the role of NO in migraine pathogenesis and in evaluating symptomatic treatments for migraine attacks. 相似文献