全文获取类型
收费全文 | 1156篇 |
免费 | 69篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 66篇 |
妇产科学 | 12篇 |
基础医学 | 114篇 |
口腔科学 | 50篇 |
临床医学 | 133篇 |
内科学 | 176篇 |
皮肤病学 | 13篇 |
神经病学 | 160篇 |
特种医学 | 272篇 |
外科学 | 62篇 |
综合类 | 25篇 |
预防医学 | 38篇 |
眼科学 | 4篇 |
药学 | 88篇 |
肿瘤学 | 36篇 |
出版年
2021年 | 5篇 |
2019年 | 6篇 |
2018年 | 17篇 |
2017年 | 8篇 |
2016年 | 7篇 |
2015年 | 15篇 |
2014年 | 17篇 |
2013年 | 16篇 |
2012年 | 14篇 |
2011年 | 19篇 |
2010年 | 36篇 |
2009年 | 29篇 |
2008年 | 21篇 |
2007年 | 43篇 |
2006年 | 37篇 |
2005年 | 31篇 |
2004年 | 27篇 |
2003年 | 38篇 |
2002年 | 28篇 |
2001年 | 27篇 |
2000年 | 20篇 |
1999年 | 23篇 |
1998年 | 63篇 |
1997年 | 79篇 |
1996年 | 84篇 |
1995年 | 56篇 |
1994年 | 41篇 |
1993年 | 43篇 |
1992年 | 26篇 |
1991年 | 17篇 |
1990年 | 28篇 |
1989年 | 41篇 |
1988年 | 46篇 |
1987年 | 36篇 |
1986年 | 33篇 |
1985年 | 38篇 |
1984年 | 12篇 |
1983年 | 13篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 14篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 8篇 |
1971年 | 4篇 |
1970年 | 4篇 |
1969年 | 4篇 |
1966年 | 2篇 |
排序方式: 共有1253条查询结果,搜索用时 15 毫秒
1.
Isolated patellofemoral arthritis is an increasingly recognized entity, and is usually associated with previous patellofemoral dysplasia or instability. Patellofemoral arthroplasty (PFA) has evolved significantly in recent years, both in terms of implant design and importantly in the understanding of appropriate patient selection. This review outlines the indications and investigations for PFA, provides a brief history of the development of contemporary implants, and presents the clinical outcomes for the prostheses most commonly used in the UK. In addition, it provides a detailed surgical technique for implantation of an onlay implant, with tips on how to optimize patellofemoral biomechanics and thus achieve a consistently good outcome. 相似文献
2.
3.
Sonoelasticity imaging of prostate cancer: in vitro results 总被引:2,自引:0,他引:2
4.
5.
6.
7.
S. Shaikh D. A. Collier P. Sham L. Pilowsky T. Sharma L. K. Lin M. A. Crocq M. Gill R. Kerwin 《American journal of medical genetics. Part A》1995,60(6):541-545
We have examined the hypothesis that a variable number of tandem repeats in the third cytoplasmic loop of the dopamine D4 receptor influences clinical response to clozapine using a sample of 189 schizophrenic patients. Alleles of the 48-bp repeat, which range from two to ten copies in the normal human population, were analysed by the polymerase chain reaction using genomic DNA as template. Association between these alleles and response to clozapine was tested using the difference in pre-and post-treatment GAS scores as a measure of response. We found no statistically significant variation between genotypic groups and response by analysis of variance. We conclude that the variation of the number of 48-bp repeats alone does not determine response to clozapine. Larger studies are underway to determine if there is a more subtle relationship with sequence variation within the repeats or at other polymorphic sites within the gene that may provide evidence for a component of clozapine's action being at D4 receptors. © 1995 Wiley-Liss, Inc. 相似文献
8.
9.
Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in their transfusion response. All patients were receiving multiple platelet transfusions without achieving 1-hour corrected count increments (CCIs) > or = 7500. Eight patients had antibodies that reacted with platelets and were directed against HLA class I antigens, ABO antigens, and/or platelet-specific alloantigens. Plasma (500-2000 mL) from each patient was passed over a protein A silica gel column and then returned to the patient. Patients received from 1 to 14 treatments. A positive response to protein A therapy was defined as at least a doubling of the pretreatment platelet count and/or two successive 10- to 120-minute posttransfusion CCIs > or = 7500. Following plasma treatments, 6 of 10 patients responded with daily platelet counts that averaged 48 +/− 11 × 10(9) per L as compared with counts of 16 +/− 7 × 10(9) per L (p < 0.0005) before treatment. Posttransfusion CCI values determined in four of these patients averaged 2480 +/− 810 and 10,010 +/− 3540 (p < 0.005) before and after treatment, respectively. In contrast, among the four unresponsive patients, platelet counts averaged 10 +/− 9 and 13 +/− 10 × 10(9) per L (p = NS), respectively, while posttransfusion CCIs were 700 +/− 1410 and 1520 +/− 2460 (p = NS), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.
Geraldo F. Busatto Lyn S. Pilowsky Durval C. Costa John Mertehs Dirk Terriere Peter J. Ell Rachel Mulligan Michael J. Travis Josée E. Leysen Dominic Lui Sveto Gacinovic Wendy Waddington Anne Lingford-Hughes Robert W. Kerwin 《European journal of nuclear medicine and molecular imaging》1997,24(2):119-124
The mapping of 5-HT2 receptors in the brain using functional imaging techniques has been limited by a relative lack of selective radioligands.
Iodine-123 labelled 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150 or123I-R93274) is a new ligand for single-photon emission tomography (SPET), with high affinity and selectivity for 5-HT2A receptors. This study reports on preliminary123I-5-I-R91150 SPET, wholebody and blood distribution findings in five healthy human volunteers. Maximal brain uptake was approximately
2% of total body counts at 180 min post injection (p.i.). Dynamic SPET sequences were acquired with the brain-dedicated, single-slice
multi-detector system SEM-810 over 200 min p.i. Early peak uptake (at 5 min p.i.) was seen in the cerebellum, a region free
from 5HT2A receptors. In contrast, radioligand binding in the frontal cortex increased steadily over time, up to a peak at approximately
100–120 min p.i. Frontal cortex-cerebellum activity ratios reached values of 1.4, and remained stable from approximately 100
min p.i. onwards. Multi-slice SPET sequences showed a pattern of regional variation of binding compatible with the autoradiographic
data on the distribution of 5-HT2A receptors in (cerebral cortex>striatum>cerebellum). These findings suggest that123I-5-I-R91150 may be used for the imaging of 5-HT2A receptors in the living human brain with SPET. 相似文献