全文获取类型
收费全文 | 3949篇 |
免费 | 265篇 |
国内免费 | 89篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 114篇 |
妇产科学 | 47篇 |
基础医学 | 464篇 |
口腔科学 | 87篇 |
临床医学 | 356篇 |
内科学 | 875篇 |
皮肤病学 | 296篇 |
神经病学 | 208篇 |
特种医学 | 246篇 |
外科学 | 398篇 |
综合类 | 235篇 |
预防医学 | 239篇 |
眼科学 | 185篇 |
药学 | 273篇 |
3篇 | |
中国医学 | 66篇 |
肿瘤学 | 173篇 |
出版年
2023年 | 24篇 |
2022年 | 57篇 |
2021年 | 89篇 |
2020年 | 65篇 |
2019年 | 97篇 |
2018年 | 126篇 |
2017年 | 86篇 |
2016年 | 83篇 |
2015年 | 108篇 |
2014年 | 95篇 |
2013年 | 169篇 |
2012年 | 254篇 |
2011年 | 239篇 |
2010年 | 152篇 |
2009年 | 103篇 |
2008年 | 180篇 |
2007年 | 214篇 |
2006年 | 207篇 |
2005年 | 210篇 |
2004年 | 168篇 |
2003年 | 160篇 |
2002年 | 160篇 |
2001年 | 140篇 |
2000年 | 137篇 |
1999年 | 123篇 |
1998年 | 55篇 |
1997年 | 49篇 |
1996年 | 43篇 |
1995年 | 44篇 |
1994年 | 35篇 |
1993年 | 39篇 |
1992年 | 42篇 |
1991年 | 39篇 |
1990年 | 50篇 |
1989年 | 50篇 |
1988年 | 63篇 |
1987年 | 70篇 |
1986年 | 40篇 |
1985年 | 31篇 |
1984年 | 22篇 |
1983年 | 24篇 |
1982年 | 13篇 |
1981年 | 21篇 |
1980年 | 21篇 |
1979年 | 9篇 |
1978年 | 10篇 |
1975年 | 8篇 |
1971年 | 9篇 |
1969年 | 7篇 |
1967年 | 12篇 |
排序方式: 共有4303条查询结果,搜索用时 0 毫秒
1.
M Gómez-Silva L Garza-Oca?as N Waksman V Rivas A Pi?eyro-López 《Toxicology in vitro》2005,19(1):47-53
T-514 (Peroxisomicine A(1)) from Karwinskia humboldtiana is a dimeric hydroxyanthracenone with a highly selective cytotoxic effect on tumor cells. We evaluated the metabolism of this compound in two in vitro systems (liver microsomes and hepatocytes) and assessed the cytotoxicity of its metabolites on normal and tumor cells. Microsomes (12.5, 125 and 250 microg of protein/ml) and hepatocytes (1 x 10(6) cells/ml) were incubated with the toxin (25 microM) for 0.5, 1, 3, 6, 9, 12 and 24 h and the samples were examined using chromatographic analysis and UV spectra. Two metabolites (M1 and M2) were detected in the rat microsomes and one (M1) in the monkey microsomes. The retention times and UV spectra of the peaks were very similar to those of the toxin T-514. M1 was isolated and identified as a mixture of two isomers. The cytotoxicity of the metabolites was evaluated in Chang liver and Hep G2 cells but they did not show the selective cytotoxic effect on tumor cells seen in the original compound. 相似文献
2.
Marcela Hernández Hoyos Piotr Orłowski Ewa Piątkowska-Janko Piotr Bogorodzki Maciej Orkisz 《International journal of computer assisted radiology and surgery》2006,1(1):51-61
The accuracy of 2D phase contrast (PC) magnetic resonance angiography (MRA) depends on the alignment between the vessels and
the imaging plane. PC MRA imaging of blood flow is challenging when the flow in several vessels is to be evaluated with one
acquisition. For this purpose, semi-automatic determination of the plane most perpendicular to several vessels is proposed
based on centerlines extracted from 3D MRA. Arterial centerlines are extracted from 3D MRA based on iterative estimation-prediction,
multi-scale analysis of image moments, and a second-order shape model. The optimal plane is determined by minimizing misalignment
between its normal vector and the centerlines’ tangent vectors. The method was evaluated on a phantom and on 35 patients,
by seeking the optimal plane for cerebral blood flow quantification simultaneously in internal carotids and vertebral arteries.
In the phantom, difference of orientation and of height between known and calculated planes was 1.2° and 2.5 mm, respectively.
In the patients, all but one centerline were correctly extracted and the misalignment of the plane was within 12° per artery.
Semi-automatic centerline extraction simplifies and automates determination of the plane orthogonal to one vessel, thereby
permitting automatic simultaneous minimization of the misalignment with several vessels in PC MRA. 相似文献
3.
4.
5.
6.
7.
8.
9.
10.
应用ATL-ultramark超6型彩色多普勒超声诊断仪诊断扩张型心肌病100例,并与性别、年龄相应的正常人对比分析。结果:除扩张型心肌病各组室间隔及左室后壁舒张期厚度与相应正常对照组相比无显著性差异(P>0.05)外,其左室舒张内径及收缩内径、左房内径明显大于正常对照组(P<0.01),左室射血分数及左室内径缩短分数较正常对照组明显降低(P<0.01),并见心腔内血流速度缓慢,颜色变淡。另在77例病人中探及40例瓣膜返流。提示该诊断方法对扩张型心肌病具有直观、简便、准确、迅速的优点,为本病的诊断及鉴别诊断提供了良好的手段。 相似文献