全文获取类型
收费全文 | 901篇 |
免费 | 55篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 11篇 |
妇产科学 | 7篇 |
基础医学 | 91篇 |
口腔科学 | 25篇 |
临床医学 | 97篇 |
内科学 | 160篇 |
皮肤病学 | 46篇 |
神经病学 | 77篇 |
特种医学 | 100篇 |
外科学 | 129篇 |
综合类 | 82篇 |
预防医学 | 42篇 |
眼科学 | 8篇 |
药学 | 111篇 |
中国医学 | 1篇 |
肿瘤学 | 42篇 |
出版年
2021年 | 12篇 |
2020年 | 4篇 |
2019年 | 15篇 |
2018年 | 21篇 |
2017年 | 14篇 |
2016年 | 19篇 |
2015年 | 13篇 |
2014年 | 19篇 |
2013年 | 17篇 |
2012年 | 18篇 |
2011年 | 33篇 |
2010年 | 29篇 |
2009年 | 26篇 |
2008年 | 29篇 |
2007年 | 78篇 |
2006年 | 42篇 |
2005年 | 39篇 |
2004年 | 47篇 |
2003年 | 30篇 |
2002年 | 29篇 |
2001年 | 20篇 |
2000年 | 25篇 |
1999年 | 17篇 |
1998年 | 28篇 |
1997年 | 30篇 |
1996年 | 29篇 |
1995年 | 21篇 |
1994年 | 18篇 |
1993年 | 24篇 |
1992年 | 21篇 |
1991年 | 15篇 |
1990年 | 7篇 |
1989年 | 19篇 |
1988年 | 15篇 |
1987年 | 20篇 |
1986年 | 18篇 |
1985年 | 24篇 |
1984年 | 8篇 |
1983年 | 12篇 |
1982年 | 12篇 |
1981年 | 13篇 |
1980年 | 12篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 12篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有1031条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Meta-analysis of the effects of educational and psychosocial interventions on management of diabetes mellitus 总被引:4,自引:0,他引:4
A meta-analysis of the literature of controlled studies of educational and psychosocial interventions in the treatment of diabetes mellitus yielded 93 studies of 7451 patients testing the effects of eight intervention types: (1) didactic education, (2) enhanced education, (3) diet instruction, (4) exercise instruction, (5) self-monitoring instruction, (6) social learning/behavior modification, (7) counseling, and (8) relaxation training. An overall mean effect size (ES) of +0.51 +/- 0.11 was found moderate but significant (P less than 0.05) improvements for all intervention subjects. Physical outcome and knowledge gain were most affected, followed by psychological status and compliance. Diet instruction and social learning interventions showed the strongest (ES = +0.68 +/- 0.58 and ES = +0.57 +/- 0.42, respectively) and relaxation training the weakest (ES = +0.30 +/- 0.74) effects. Associations between study and sample characteristics and mean ES values were explored with type of setting and methodological weaknesses such as single group design and non-random assignment achieving statistical significance. Neither intervention type, number of visits, sex, age, nor type of diabetes were significantly correlated with mean ES values. Implications of these findings for clinical treatment and future research are discussed. 相似文献
6.
7.
Background: The fabrication of dental prosthesis requires the transfer of interocclusal records from patient's mouth to semiadjustable articulators using different kinds of recording media. Any inaccuracy in these interocclusal records leads to occlusal errors in the final prosthesis. This study was conducted to evaluate the dimensional changes occurring in the interocclusal recording material over a given period of time and the material's resistance to compression during the cast mounting on the articulator. 相似文献
8.
9.
O H Choi W L Padgett J W Daly 《The Journal of pharmacology and experimental therapeutics》1992,260(1):369-375
Two amphiphilic peptides from hymenopterid insects, melittin and mastoparan, stimulate secretion in a variety of cell types. In PC12 cells, both peptides stimulate calcium influx with melittin some 20-fold more potently than mastoparan. Melittin stimulates both breakdown of phosphoinositides (Pl) by phospholipase C to yield inositol phosphates and hydrolysis of phospholipids by phospholipase A2 to release arachidonic acid (AA). Mastoparan stimulates Pl breakdown, but has no effect on AA release. Maximal stimulation of Pl breakdown occurs at 1 to 2.5 micrograms/ml melittin and 30 micrograms/ml mastoparan, whereas maximal stimulation of AA release occurs at 2 to 5 micrograms/ml melittin. Organic calcium channel blockers (nifedipine, verapamil, diltiazem) have little or no effect on responses to the peptides. The influx of calcium elicited by melittin or mastoparan is completely or nearly completely blocked by inorganic calcium channel blockers (Co++, Mn++, Cd++). Mn++ and Cd++ inhibit melittin-induced Pl breakdown and AA release and mastoparan-induced Pl breakdown. Co++ has no effect on melittin-induced Pl breakdown and potentiates mastoparan-induced Pl breakdown. Pertussis toxin has no effect on the Pl breakdown induced by either peptide. The responses to melittin and mastoparan in PC12 cells are compared to those reported for maitotoxin. 相似文献
10.
Ronald B. Stewart Ronald G. Marks Phillip D. Padgett William E. Hale 《Pharmacoepidemiology and drug safety》1994,3(1):23-29
The objective of the work was to identify changes in antidepressant drug use and determine if the prevalence of antidepressant use has changed over 14 years. A longitudinal analysis comparing antidepressant drug use at 14 yearly intervals from 1978–79 to 1991–92 was undertaken using the longitudinal health screening program of ambulatory elderly participants (Florida Geriatric Research Program). Participants included all subjects screened in the Florida Geriatric Research Program from 1 August 1978 to 31 July 1992. The outcome measures were self-reported antidepressant drug use. Approximately 3.0 per cent (range of 2.3 to 3.2 per cent over 14 yearly intervals) of participants in this program reported the use of an antidepressant drug. There was no statistically significant change in antidepressant use between 1978–79 and 1991–92 (p > 0.6630). Across all study intervals women reported more frequent use of antidepressant drugs than men. In 1991–92, amitriptyline and imipramine represented over 50 per cent of all antidepressant drug use in this elderly population. Less than 6 per cent of all antidepressant drug use was for fluoxetine, the newest selective serotonin uptake inhibitor. The majority of elderly patients are receiving older tertiary amine tricyclic antidepressants such as amitriptyline, imipramine and doxepin that are not the preferred drugs for the elderly. Educational programs are needed to improve antidepressant prescribing for geriatric patients. 相似文献