Synthesis and Antimicrobial Activity of 4-(4-Acetylphenyl)-3-Hydroxy-2H-Chromen-2-One Derivatives

Pharmaceutical Chemistry Journal - Reactions of 4-(4-bromoacetylphenyl)-3-hydroxy-2H-chromen-2-one with Py, 4-methylpyridine, quinoline, and benzo[f]quinoline produced quaternary salts; with...     

Synthesis and Antimicrobial Activity of 3-Phenyl-1-Methylquinolin-2-One Derivatives

Pharmaceutical Chemistry Journal - A series of quaternary salts were obtained by reacting 3-(4-bromoacetylphenyl)-1-methylquinolin-2(1H)-one with Py, 4-methylpyridine, quinoline, benzo[f]quinoline,...     

Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles

Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1H-pyrazole synthesis via 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity products were isolated by simple filtration. The selectivity of the reaction was observed.

Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1H-pyrazole synthesis via 1,3-dipolar cycloaddition.     

Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides

The antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides and their 3-substituted analogs has been studied. The initial acid was obtained by an effective one-pot method using the reaction of thiourea with maleic anhydride in hydrochloric acid. The maximum anti-staphylococcal activity was exhibited by N-[5-(R-benzyl)thiazol-2-yl]-2-(2,4-dioxothiazolidin-5-yl)acetamides. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 6, pp. 13–16, June, 2006.     

Synthesis and Antimicrobial Activity of 5-(R<Superscript>1</Superscript>-benzyl)-2-(R<Superscript>2</Superscript>-benzylidenehydrazono)-3-(2-furylmethyl)Thiazolidin-4-ones

3-Aryl-2-bromopropanoic acid esters react with furfurylthiosemicarbazones of benzaldehyde and 4-chlorobenzaldehyde to form 5-(R¹-benzyl)-2-(4-R-benzylidenehydrazono)-3-furfuryl-4-thiazolidinones (R = H, 4-Cl; R¹ = 4-Me, 4-F, 4-Cl). The antimicrobial activity of the synthesized compounds was studied, and it was established that only the compounds with R¹ = Me are active. The replacement of methyl group by halogen results in the loss of antimicrobial activity. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 5, pp. 20 – 22, May, 2005.