全文获取类型
收费全文 | 3517篇 |
免费 | 234篇 |
国内免费 | 95篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 61篇 |
妇产科学 | 66篇 |
基础医学 | 474篇 |
口腔科学 | 315篇 |
临床医学 | 276篇 |
内科学 | 907篇 |
皮肤病学 | 61篇 |
神经病学 | 295篇 |
特种医学 | 88篇 |
外科学 | 375篇 |
综合类 | 26篇 |
预防医学 | 348篇 |
眼科学 | 42篇 |
药学 | 355篇 |
中国医学 | 20篇 |
肿瘤学 | 94篇 |
出版年
2023年 | 49篇 |
2022年 | 86篇 |
2021年 | 178篇 |
2020年 | 100篇 |
2019年 | 127篇 |
2018年 | 155篇 |
2017年 | 109篇 |
2016年 | 116篇 |
2015年 | 134篇 |
2014年 | 165篇 |
2013年 | 191篇 |
2012年 | 272篇 |
2011年 | 306篇 |
2010年 | 150篇 |
2009年 | 111篇 |
2008年 | 210篇 |
2007年 | 225篇 |
2006年 | 164篇 |
2005年 | 197篇 |
2004年 | 104篇 |
2003年 | 104篇 |
2002年 | 109篇 |
2001年 | 84篇 |
2000年 | 65篇 |
1999年 | 54篇 |
1998年 | 15篇 |
1997年 | 22篇 |
1996年 | 23篇 |
1995年 | 10篇 |
1994年 | 17篇 |
1993年 | 12篇 |
1992年 | 22篇 |
1991年 | 27篇 |
1990年 | 17篇 |
1989年 | 26篇 |
1988年 | 10篇 |
1987年 | 8篇 |
1986年 | 11篇 |
1985年 | 5篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1979年 | 9篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1970年 | 3篇 |
1969年 | 2篇 |
1967年 | 3篇 |
排序方式: 共有3846条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Amanda Leal Rocha Alessandra Figueiredo De Souza Laiz Fernandes Mendes Nunes Nayara Dias de Souza Cunha Clia Regina Moreira Lanza Denise Vieira Travassos Tarcília Aparecida da Silva 《Pediatric dermatology》2019,36(1):e27-e30
Drug‐induced reactions are complications associated with high mortality and significant morbidity. Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9‐year‐old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. A drug‐induced hypersensitivity reaction to antibiotics was suspected, and a diagnosis of TEN was made. The patient was managed with withdrawal of the suspected causative agent, and the oral lesions were treated with low‐level laser therapy (LLLT) and oral hygiene. This case highlights that TEN requires interdisciplinary intervention with dental assistance and follow‐up to improve symptoms, nutrition, systemic condition, and quality of life. 相似文献
5.
Teresa Nunes José Paulo Monteiro José Carlos Ferreira Pedro Vilela 《European radiology》2009,19(10):2551-2554
L1 disease is the most common genetic cause of congenital hydrocephalus. Mutations in the L1CAM gene are associated with an overlapping clinical spectrum of four X-linked neurological conditions, characterized by hydrocephalus, mental retardation, lower limb spasticity and adducted thumbs. Brain anomalies are frequently present in L1 disease. We describe these anomalies by reporting a case of a male newborn presenting with congenital hydrocephalus along with corpus callosum agenesis and enlargement of the massa intermedia. These findings, in association with the presence of clasped thumbs, raised the suspicion of L1 disease, which was confirmed by the detection of a mutation in the L1CAM gene. In cases of congenital hydrocephalus, recognition of the brain anomalies associated with L1 disease may contribute to pursuing the genetic analysis needed for the diagnosis and genetic counseling. 相似文献
6.
Lázaro Alessandro S Nunes Paulo Guimar?es Gandra Armindo Antonio Alves Lauro T Kubota Denise Vaz de Macedo 《Clinical journal of sport medicine》2006,16(5):418-421
OBJECTIVE: The authors tested the effect of blood sampling (skin versus venous puncture) on some biochemical and hematological blood parameters in athletes to answer whether skin puncture could be used as a substitute for venous puncture. DESIGN: Comparative study of 2 methods of blood samples collection. SETTING: The blood was collected in the same athletes at 3 different moments of the preparatory training phase. PARTICIPANTS: Fourteen male indoor soccer players (22 +/- 1 years old) and 7 female handball players (18 +/- 1 years old) participated. MAIN OUTCOME MEASUREMENT: Blood was collected in heparin and K3EDTA by Vacutainer BD or Microvette Sarstedt system for biochemical and hematological analyses, respectively. RESULTS: There were no significant statistical differences between the 2 methods for the values of creatine kinase, urea, creatinine, lymphocytes, and platelets. The other hematological analyzes and uric acid exhibited significant higher values in skin blood, although they were all within the normal expected range. A high degree of correlation was observed between the 2 techniques for all parameters. CONCLUSIONS: Skin puncture is a reliable, easy, accurate, and less invasive sampling method for assessing hematological and some biochemical parameters in athletes, respecting that blood samples should always be obtained from the same site, especially in follow-up studies. 相似文献
7.
8.
9.
无环鸟苷亲脂性前体药物脂质体的制备及体外抗病毒活性(英文) 总被引:2,自引:0,他引:2
本文通过将无环鸟苷(acyclovir,简称ACV)2’位羟基分别与月桂酰氯或棕榈酰氯进行酯化反应,制得亲脂性前体药物无环鸟苷月桂酸酯和无环鸟苷棕榈酸酯(分别简称为C12-ACV和C16-ACV),使脂质体包封率从ACV的29.9%提高到C12-ACV的95.6%和C16-ACV的97.1%;漏泄实验表明在4℃透析60h后,一半以上的ACV从脂质体中漏泄,而C12-ACV和C16-ACV的滞留率分别为70%和80%;体外抗疱疹病毒的试验中,在最低试验浓度0.044μmol/L时,ACV不显示抗病毒活性,而C16-ACV脂质体抑制细胞病变率达75%,说明前体药物通过与脂质体脂膜的结合增加了药物的进入细胞能力,从而提高了ACV的抗病毒能力。 相似文献
10.