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排序方式: 共有6447条查询结果,搜索用时 15 毫秒
1.
Rebecca L. King Albert C. Yan Debora R. Sekiguchi John K. Choi 《Journal of cutaneous pathology》2015,42(12):1012-1017
Reactive lymphoid infiltrates of the skin composed predominantly of gamma‐delta (γδ) T cells are not well described in the literature. Herein we report a case of an otherwise healthy 4‐year‐old male who presented with a waxing and waning papular rash characterized by small, discrete crusted papules spread across his trunk, face and extremities. Clinical evaluation revealed no evidence of systemic disease. Microscopic examination revealed a dermal, perivascular infiltrate of highly atypical lymphocytes with a γδ T cell phenotype, worrisome for primary cutaneous γδ T cell lymphoma. The clinical course, however, was that of a reactive condition and prompted consideration of a diagnosis of pityriasis lichenoides et varioliformis acuta (PLEVA) and lymphomatoid papulosis (LyP). In many ways, this case defies current classification schemes and seems to expand the spectrum of reactive γδ T cell infiltrates of the skin. 相似文献
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High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase 总被引:12,自引:4,他引:8
Iwakuma T; Sakumi K; Nakatsuru Y; Kawate H; Igarashi H; Shiraishi A; Tsuzuki T; Ishikawa T; Sekiguchi M 《Carcinogenesis》1997,18(8):1631-1635
The enzyme O6-methylguanine-DNA methyltransferase repairs alkylation-
induced DNA damage, O6-methylguanine and O4-methylthymine, the former being
formed more frequently. Previously, by means of gene targeting, we
generated mice in which alleles for methyltransferase were disrupted. We
now use these mouse lines, which are totally deficient in methyltransferase
activity, to examine protective effects of the enzyme against tumor
formation. In gene-targeted female mice given an i.p. injection of 5 mg/kg
of dimethylnitrosamine, a larger number of liver and lung tumors occurred,
as compared with normal female mice treated in the same manner. In male
mice given a lower dose of carcinogen, the difference between normal and
gene-targeted mice was statistically insignificant although more tumors did
form in the gene-targeted mice. Methyltransferase apparently afforded
protection from nitrosamine- induced tumorigenesis.
相似文献
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Katsumi Shigemura Soichi Arakawa Kunito Yamanaka Nobuo Kataoka Keiji Yuien Masato Fujisawa 《International journal of urology》2007,14(10):935-938
OBJECTIVES: Lateral biopsies are thought to have a better cancer detection rate compared with standard sextant biopsies. This study aimed to determine whether lateral peripheral zone biopsies in Japanese men who underwent transrectal ultrasound-guided prostate biopsies provided a significantly higher cancer detection rate than sextant biopsies. METHODS: Between 1999 and 2004, data were collected from 461 men who underwent prostate biopsy and had enough data regarding the performance of lateral biopsies for statistical analysis. There were two categories in this study: (i) patients who underwent sextant prostate biopsies; and (ii) patients who underwent sextant biopsies plus lateral biopsies. RESULTS: Prostate cancer was detected in 141 (30.6%) of 461 patients. It was detected in 24 (22.2%) of 108 patients who underwent sextant biopsies and 117 (33.1%) of 353 patients who underwent sextant plus lateral biopsies. Lateral biopsies were not associated with a statistically higher rate of positive biopsy findings; however, we found a significantly higher ratio of patients with positive findings in those with prostate specific antigen (PSA) levels 10 ng/mL (one of 71, 1.4%) among those who had positive cores only in lateral biopsy samples (P < 0.0001). CONCLUSIONS: Lateral biopsies did not show a significantly higher detection ratio of prostate cancer compared to sextant biopsies. However, lateral biopsies were more effective than sextant biopsies in patients with lower PSA levels. Our findings might be useful for the establishment of biopsy strategies to detect prostate cancer, especially in patients with lower PSA levels. 相似文献
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Histamine-type 2 antagonists (H2-blockers) as represented by cimentidine have been shown to adversely affect renal allograft function, particularly when coadministered
with cyclosporine, currently a major immunosuppressant. To determine whether or not a newer and more powerful H2-blocker, famotidine, would produce similar adverse effects, we assessed seven cyclosporine-treated renal allograft recipients
with regard to changes in their renal function on or off the H2-blocker over a one-week period. Neither the administration nor withdrawal of famotidine (20–40 mg/day) resulted in any significant
changes in serum creatine, BUN, urine output or cyclosporine trough levels, suggesting that famotidine can be safely administered
as an H2-blocker to cyclosporine-treated renal allograft recipients. 相似文献